Search Results - "Higo, Tomoaki"

Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure by Yamaguchi, Toshihiro, Sumida, Tomokazu S., Nomura, Seitaro, Satoh, Masahiro, Higo, Tomoaki, Ito, Masamichi, Ko, Toshiyuki, Fujita, Kanna, Sweet, Mary E., Sanbe, Atsushi, Yoshimi, Kenji, Manabe, Ichiro, Sasaoka, Toshikuni, Taylor, Matthew R. G., Toko, Haruhiro, Takimoto, Eiki, Naito, Atsuhiko T., Komuro, Issei

“…Pathophysiological roles of cardiac dopamine system remain unknown. Here, we show the role of dopamine D1 receptor (D1R)-expressing cardiomyocytes (CMs) in…”
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Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure by Nomura, Seitaro, Satoh, Masahiro, Fujita, Takanori, Higo, Tomoaki, Sumida, Tomokazu, Ko, Toshiyuki, Yamaguchi, Toshihiro, Tobita, Takashige, Naito, Atsuhiko T., Ito, Masamichi, Fujita, Kanna, Harada, Mutsuo, Toko, Haruhiro, Kobayashi, Yoshio, Ito, Kaoru, Takimoto, Eiki, Akazawa, Hiroshi, Morita, Hiroyuki, Aburatani, Hiroyuki, Komuro, Issei

“…Pressure overload induces a transition from cardiac hypertrophy to heart failure, but its underlying mechanisms remain elusive. Here we reconstruct a…”
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Pemafibrate suppresses NLRP3 inflammasome activation in the liver and heart in a novel mouse model of steatohepatitis-related cardiomyopathy by Kanno, Kotaro, Koseki, Masahiro, Chang, Jiuyang, Saga, Ayami, Inui, Hiroyasu, Okada, Takeshi, Tanaka, Katsunao, Asaji, Masumi, Zhu, Yinghong, Ide, Seiko, Saito, Shigeyoshi, Higo, Tomoaki, Okuzaki, Daisuke, Ohama, Tohru, Nishida, Makoto, Kamada, Yoshihiro, Ono, Masafumi, Saibara, Toshiji, Yamashita, Shizuya, Sakata, Yasushi

“…Although patients with nonalcoholic fatty liver disease have been reported to have cardiac dysfunction, and appropriate model has not been reported. We…”
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DNA single-strand break-induced DNA damage response causes heart failure by Higo, Tomoaki, Naito, Atsuhiko T., Sumida, Tomokazu, Shibamoto, Masato, Okada, Katsuki, Nomura, Seitaro, Nakagawa, Akito, Yamaguchi, Toshihiro, Sakai, Taku, Hashimoto, Akihito, Kuramoto, Yuki, Ito, Masamichi, Hikoso, Shungo, Akazawa, Hiroshi, Lee, Jong-Kook, Shiojima, Ichiro, McKinnon, Peter J., Sakata, Yasushi, Komuro, Issei

“…The DNA damage response (DDR) plays a pivotal role in maintaining genome integrity. DNA damage and DDR activation are observed in the failing heart, however,…”
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Homogeneous 2D and 3D alignment of cardiomyocyte in dilated cardiomyopathy revealed by intravital heart imaging by Masuyama, Kiyoshi, Higo, Tomoaki, Lee, Jong-Kook, Matsuura, Ryohei, Jones, Ian, Bakal, Chris, Higo, Shuichiro, Morimoto, Sachio, Miyagawa, Shigeru, Sawa, Yoshiki, Sakata, Yasushi

“…In contrast to hypertrophic cardiomyopathy, there has been reported no specific pattern of cardiomyocyte array in dilated cardiomyopathy (DCM), partially…”
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Twin Study: The Factors Affecting the Serum LDL-C and HDL-C Levels and an RNA-Seq Analysis in Mononuclear Cells in Monozygotic Twins by Nishihara, Sae, Koseki, Masahiro, Tanaka, Katsunao, Omatsu, Takashi, Sawabe, Hiroshi, Inui, Hiroyasu, Saga, Ayami, Okada, Takeshi, Higo, Tomoaki, Ohama, Tohru, Nishida, Makoto, Sakata, Yasushi, Watanabe, Mikio, Group, Osaka Twin Research

“…Aim: A twin study is a valuable tool for elucidating the acquired factors against lifestyle diseases such as dyslipidemia, diabetes mellitus, and obesity. We…”
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Targeted Genome Replacement via Homology-directed Repair in Non-dividing Cardiomyocytes by Ishizu, Takamaru, Higo, Shuichiro, Masumura, Yuki, Kohama, Yasuaki, Shiba, Mikio, Higo, Tomoaki, Shibamoto, Masato, Nakagawa, Akito, Morimoto, Sachio, Takashima, Seiji, Hikoso, Shungo, Sakata, Yasushi

“…Although high-throughput sequencing can elucidate the genetic basis of hereditary cardiomyopathy, direct interventions targeting pathological mutations have…”
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Activation of DNA Damage Response and Cellular Senescence in Cardiac Fibroblasts Limit Cardiac Fibrosis After Myocardial Infarction by Shibamoto, Masato, Higo, Tomoaki, Naito, Atsuhiko T., Nakagawa, Akito, Sumida, Tomokazu, Okada, Katsuki, Sakai, Taku, Kuramoto, Yuki, Yamaguchi, Toshihiro, Ito, Masamichi, Masumura, Yuki, Higo, Shuichirou, Lee, Jong-Kook, Hikoso, Shungo, Komuro, Issei, Sakata, Yasushi

“…Cardiac fibrosis plays an important role in cardiac remodeling after myocardial infarction (MI). The molecular mechanisms that promote cardiac fibrosis after…”
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A Dietary Oxysterol, 7-Ketocholesterol, Exacerbates Imiquimod-Induced Psoriasis-like Dermatitis in Steatohepatitic Mice by Saga, Ayami, Koseki, Masahiro, Kanno, Kotaro, Chang, Jiuyang, Higo, Tomoaki, Okuzaki, Daisuke, Okada, Takeshi, Inui, Hiroyasu, Asaji, Masumi, Tanaka, Katsunao, Omatsu, Takashi, Nishihara, Sae, Zhu, Yinghong, Ito, Kaori, Hattori, Hiroaki, Ichi, Ikuyo, Kamada, Yoshihiro, Ono, Masafumi, Saibara, Toshiji, Ohama, Tohru, Hikoso, Shungo, Nishida, Makoto, Yamashita, Shizuya, Sakata, Yasushi

“…Patients with psoriasis are at a higher risk of developing nonalcoholic fatty liver disease. We previously identified an oxidized derivative of cholesterol,…”
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Generation of Fabry cardiomyopathy model for drug screening using induced pluripotent stem cell-derived cardiomyocytes from a female Fabry patient by Kuramoto, Yuki, Naito, Atsuhiko T., Tojo, Hiromasa, Sakai, Taku, Ito, Masamichi, Shibamoto, Masato, Nakagawa, Akito, Higo, Tomoaki, Okada, Katsuki, Yamaguchi, Toshihiro, Lee, Jong-Kook, Miyagawa, Shigeru, Sawa, Yoshiki, Sakata, Yasushi, Komuro, Issei

“…Fabry disease is an X-linked disease caused by mutations in α-galactosidase A (GLA); these mutations result in the accumulation of its substrates, mainly…”
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Dietary Oxysterol, 7-Ketocholesterol Accelerates Hepatic Lipid Accumulation and Macrophage Infiltration in Obese Mice by Chang, Jiuyang, Koseki, Masahiro, Saga, Ayami, Kanno, Kotaro, Higo, Tomoaki, Okuzaki, Daisuke, Okada, Takeshi, Inui, Hiroyasu, Tanaka, Katsunao, Asaji, Masumi, Zhu, Yinghong, Kamada, Yoshihiro, Ono, Masafumi, Saibara, Toshiji, Ichi, Ikuyo, Ohama, Tohru, Nishida, Makoto, Yamashita, Shizuya, Sakata, Yasushi

“…Non-alcoholic fatty liver disease is strongly associated with obese and type 2 diabetes. It has been reported that an oxidized cholesterol, 7-ketocholesterol…”
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Phenotypic Screening Using Patient-Derived Induced Pluripotent Stem Cells Identified Pyr3 as a Candidate Compound for the Treatment of Infantile Hypertrophic Cardiomyopathy by Sakai, Taku, Naito, Atsuhiko T., Kuramoto, Yuki, Ito, Masamichi, Okada, Katsuki, Higo, Tomoaki, Nakagawa, Akito, Shibamoto, Masato, Yamaguchi, Toshihiro, Sumida, Tomokazu, Nomura, Seitaro, Umezawa, Akihiro, Miyagawa, Shigeru, Sawa, Yoshiki, Morita, Hiroyuki, Lee, Jong-Kook, Shiojima, Ichiro, Sakata, Yasushi, Komuro, Issei

“…Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by hypertrophy of the myocardium. Some of the patients are diagnosed for HCM…”
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Generation of Induced Pluripotent Stem Cells From Patients With Duchenne Muscular Dystrophy and Their Induction to Cardiomyocytes by Hashimoto, Akihito, Naito, Atsuhiko T., Lee, Jong-Kook, Kitazume-Taneike, Rika, Ito, Masamichi, Yamaguchi, Toshihiro, Nakata, Ryo, Sumida, Tomokazu, Okada, Katsuki, Nakagawa, Akito, Higo, Tomoaki, Kuramoto, Yuki, Sakai, Taku, Tominaga, Koji, Okinaga, Takeshi, Kogaki, Shigetoyo, Ozono, Keiichi, Miyagawa, Shigeru, Sawa, Yoshiki, Sakata, Yasushi, Morita, Hiroyuki, Umezawa, Akihiro, Komuro, Issei

“…Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene which encodes dystrophin protein. Dystrophin defect affects cardiac muscle as well as…”
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Risk of in-stent thrombus formation at one year after drug-eluting stent implantation by Higo, Tomoaki, Ueda, Yasunori, Matsuo, Koshi, Nishio, Mayu, Hirata, Akio, Asai, Mitsutoshi, Nemoto, Takayoshi, Murakami, Ayaka, Kashiwase, Kazunori, Kodama, Kazuhisa

“…Abstract Introduction Although very late stent thrombosis is an important problem with drug-eluting stents, risks for in-stent thrombus formation have not been…”
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Chronic Kidney Disease and Coronary Artery Vulnerable Plaques by Wada, Mitsuru, Ueda, Yasunori, Higo, Tomoaki, Matsuo, Koshi, Nishio, Mayu, Hirata, Akio, Asai, Mitsutoshi, Nemoto, Takayoshi, Kashiyama, Toshikazu, Murakami, Ayaka, Kashiwase, Kazunori, Kodama, Kazuhisa

“…Chronic kidney disease (CKD) is a risk factor of cardiovascular disease. The number of yellow plaques is a predictor of future cardiovascular events. We…”
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Atherosclerotic and Thrombogenic Neointima Formed Over Sirolimus Drug-Eluting Stent by Higo, Tomoaki, MD, Ueda, Yasunori, MD, PhD, Oyabu, Jota, MD, Okada, Katsuki, MD, Nishio, Mayu, MD, PhD, Hirata, Akio, MD, PhD, Kashiwase, Kazunori, MD, PhD, Ogasawara, Nobuyuki, MD, Hirotani, Shinichi, MD, PhD, Kodama, Kazuhisa, MD, PhD

“…Objectives We sought to examine by angioscopy the neointima formation and thrombogenic potential of the neointima after deployment of a drug-eluting stent…”
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Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes by Naito, Atsuhiko T., Sumida, Tomokazu, Nomura, Seitaro, Liu, Mei-Lan, Higo, Tomoaki, Nakagawa, Akito, Okada, Katsuki, Sakai, Taku, Hashimoto, Akihito, Hara, Yurina, Shimizu, Ippei, Zhu, Weidong, Toko, Haruhiro, Katada, Akemi, Akazawa, Hiroshi, Oka, Toru, Lee, Jong-Kook, Minamino, Tohru, Nagai, Toshio, Walsh, Kenneth, Kikuchi, Akira, Matsumoto, Misako, Botto, Marina, Shiojima, Ichiro, Komuro, Issei

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Abstract 13026: Homogeneous 2D and 3D Alignment of Cardiomyocytes in Dilated Cardiomyopathy Revealed by Intravital Heart Imaging by Masuyama, Kiyoshi, Higo, Tomoaki, Lee, Jong-Kook, Miyagawa, Shigeru, Sawa, Yoshiki, Sakata, Yasushi

“…BackgroundIn contrast to hypertrophic cardiomyopathy, there has been reported no specific pattern of cardiomyocyte array in dilated cardiomyopathy (DCM). This…”
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Cardiac hypertrophy elevates serum levels of fibroblast growth factor 23 by Matsui, Isao, Oka, Tatsufumi, Kusunoki, Yasuo, Mori, Daisuke, Hashimoto, Nobuhiro, Matsumoto, Ayumi, Shimada, Karin, Yamaguchi, Satoshi, Kubota, Keiichi, Yonemoto, Sayoko, Higo, Tomoaki, Sakaguchi, Yusuke, Takabatake, Yoshitsugu, Hamano, Takayuki, Isaka, Yoshitaka

“…Several experimental studies have shown that fibroblast growth factor 23 (FGF23) induces left ventricular hypertrophy (LVH). However, the opposite directional…”
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Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes by Naito, Atsuhiko T., Sumida, Tomokazu, Nomura, Seitaro, Liu, Mei-Lan, Higo, Tomoaki, Nakagawa, Akito, Okada, Katsuki, Sakai, Taku, Hashimoto, Akihito, Hara, Yurina, Shimizu, Ippei, Zhu, Weidong, Toko, Haruhiro, Katada, Akemi, Akazawa, Hiroshi, Oka, Toru, Lee, Jong-Kook, Minamino, Tohru, Nagai, Toshio, Walsh, Kenneth, Kikuchi, Akira, Matsumoto, Misako, Botto, Marina, Shiojima, Ichiro, Komuro, Issei

“…Wnt signaling plays critical roles in development of various organs and pathogenesis of many diseases, and augmented Wnt signaling has recently been implicated…”
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