Search Results - "Higley, C. Anne"

Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. 3. Structure Activity Relationships at C3 by Yue, Eddy W, Higley, C. Anne, DiMeo, Susan V, Carini, David J, Nugiel, David A, Benware, Carrie, Benfield, Pamela A, Burton, Catherine R, Cox, Sarah, Grafstrom, Robert H, Sharp, Diane M, Sisk, Lisa M, Boylan, John F, Muckelbauer, Jodi K, Smallwood, Angela M, Chen, Haiying, Chang, Chong-Hwan, Seitz, Steven P, Trainor, George L

“…The identification of indeno[1,2-c]pyrazol-4-ones as inhibitors of cyclin-dependent kinases (CDKs) has led to the discovery of a series of novel and potent…”
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Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3 by Yue, Eddy W., DiMeo, Susan V., Higley, C.Anne, Markwalder, Jay A., Burton, Catherine R., Benfield, Pamela A., Grafstrom, Robert H., Cox, Sarah, Muckelbauer, Jodi K., Smallwood, Angela M., Chen, Haiying, Chang, Chong-Hwan, Trainor, George L., Seitz, Steven P.

“…New indeno[1,2- c]pyrazol-4-one cyclin dependent kinase inhibitors have been disclosed. The most promising compounds are nanomolar enzyme inhibitors with…”
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Pyrazoles, 1,2,4-triazoles, and tetrazoles as surrogates for cis-amide bonds in boronate ester thrombin inhibitors by Duncia, John V., Santella, Joseph B., Anne Higley, C., VanAtten, Mary K., Weber, Patricia C., Alexander, Richard S., Kettner, Charles A., Pruitt, James R., Liauw, Anne Y., Quan, Mimi L., Knabb, Robert M., Wexler, Ruth R.

“…Substituted pyrazoles, 1,2,4-triazoles, and tetrazoles are good surrogates for cis-amide bonds in a series of boronate ester thrombin inhibitors. Substituted…”
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MEK inhibitors: The chemistry and biological activity of U0126, its analogs, and cyclization products by Duncia, John V., Santella, Joseph B., Higley, C.Anne, Pitts, William J., Wityak, John, Frietze, William E., Rankin, F.Wayne, Sun, Jung-Hui, Earl, Richard A., Tabaka, A.Christine, Teleha, Christopher A., Blom, Karl F., Favata, Margaret F., Manos, Elizabeth J., Daulerio, Andrea J., Stradley, Deborah A., Horiuchi, Kurumi, Copeland, Robert A., Scherle, Peggy A., Trzaskos, James M., Magolda, Ronald L., Trainor, George L., Wexler, Ruth R., Hobbs, Frank W., Olson, Richard E.

“…In search of antiinflammatory drugs with a new mechanism of action, U0126 was found to functionally antagonize AP-1 transcriptional activity via noncompetitive…”
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Discovery of an Orally Active Series of Isoxazoline Glycoprotein IIb/IIIa Antagonists by Xue, Chu-Biao, Wityak, John, Sielecki, Thais M, Pinto, Donald J, Batt, Douglas G, Cain, Gary A, Sworin, Michael, Rockwell, Arlene L, Roderick, John J, Wang, Shuaige, Orwat, Michael J, Frietze, William E, Bostrom, Lori L, Liu, Jie, Higley, C. Anne, Rankin, F. Wayne, Tobin, A. Ewa, Emmett, George, Lalka, George K, Sze, Jean Y, Di Meo, Susan V, Mousa, Shaker A, Thoolen, Martin J, Racanelli, Adrienne L, Hausner, Elizabeth A, Reilly, Thomas M, DeGrado, William F, Wexler, Ruth R, Olson, Richard E

“…Using isoxazoline XR299 (1a) as a starting point for the design of highly potent, long-duration GPIIb/IIIa antagonists, the effect of placing lipophilic…”
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Acyl CoA:Cholesterol Acyltransferase (ACAT) Inhibitors: Synthesis and Structure-Activity Relationship Studies of a New Series of Trisubstituted Imidazoles by Higley, C. Anne, Wilde, Richard G, Maduskuie, Thomas P, Johnson, Alexander L, Pennev, Pennio, Billheimer, Jeffrey T, Robinson, Candy S, Gillies, Peter J, Wexler, Ruth R

“…A series of 4,5-diaryl-2-(substituted thio)-1H-imidazoles has been synthesized and demonstrated to be potent inhibitors of acyl-CoA:cholesterol acyltransferase…”
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Design, Synthesis, and Structure-Activity Relationship Studies for a New Imidazole Series of J774 Macrophage Specific Acyl-CoA:Cholesterol Acyltransferase (ACAT) Inhibitors by Maduskuie, Thomas P, Wilde, Richard G, Billheimer, Jeffrey T, Cromley, Debra A, Germain, Sandra, Gillies, Peter J, Higley, C. Anne, Johnson, Alex L, Pennev, Penio, Shimshick, Edward J, Wexler, Ruth R

“…Acyl-CoA:cholesterol acyltransferase (ACAT) is the primary enzyme involved in intracellular cholesterol esterification. Arterial wall infiltration by…”
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Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: ureas bearing heterocyclic groups bioisosteric for an imidazole by Wilde, Richard G., Billheimer, Jeffrey T., Germain, Sandra J., Gillies, Peter J., Higley, C.Anne, Kezar, Hollis S., Maduskuie, Thomas P., Shimshick, Edward S., Wexler, Ruth R.

“…A series of compounds bearing heterocyclic substituents were prepared, and evaluated for inhibition of the ACAT enzyme. The heterocyclic groups were compared…”
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