Search Results - "Highet, R. J."

Sequential oxidation and glutathione addition to 1,4-benzoquinone: correlation of toxicity with increased glutathione substitution by Lau, S S, Hill, B A, Highet, R J, Monks, T J

“…The chemical reaction of 1,4-benzoquinone with glutathione results in the formation of adducts that exhibit increasing degrees of glutathione substitution…”
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Glutathione conjugates of 2-bromohydroquinone are nephrotoxic by Monks, T J, Lau, S S, Highet, R J, Gillette, J R

“…Incubation of either o-bromophenol or 2-bromohydroquinone with rat liver microsomes and 0.25 mM 35S-glutathione (GSH) gave rise to several isomeric 35S-GSH…”
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2-Bromo-(diglutathion-S-yl)hydroquinone nephrotoxicity: physiological, biochemical, and electrochemical determinants by Monks, T J, Highet, R J, Lau, S S

“…2-Bromo-(diglutathion-S-yl)hydroquinone [2-Br-(diGSyl)HQ] causes severe necrosis of the proximal renal tubules in the rat, elevations in blood urea nitrogen…”
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Immunochemical detection of liver protein adducts of the nonsteroidal antiinflammatory drug diclofenac by Pumford, Neil R, Myers, Timothy G, Davila, Julio C, Highet, Robert J, Pohl, Lance R

“…Serious idiosyncratic hepatic injury has been associated with the use of many nonsteroidal antiinflammatory drugs, including the widely prescribed agent…”
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Oxidative cyclization, 1,4-benzothiazine formation and dimerization of 2-bromo-3-(glutathion-S-yl)hydroquinone by Monks, T J, Highet, R J, Lau, S S

“…Several lines of evidence suggest that the renal-specific toxicity of quinol-linked GSH conjugates is probably a result of their metabolism by gamma-glutamyl…”
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Alkaloids from Dendrobatid Frogs: Structures of Two ω-Hydroxy Congeners of 3-Butyl-5-Propylindolizidine and Occurrence of 2,5-Disubstituted Pyrrolidines and a 2,6-Disubstituted Piperidine by Daly, J. W, Spande, T. F, Whittaker, N, Highet, R. J, Feigl, D, Nishimori, N, Tokuyama, T, Myers, C. W

“…Forty alkaloids were detected and characterized from skin extracts of high- and low-elevation populations of the poison frog Dendrobates histrionicus from…”
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Characterization by NMR of the heme-myoglobin adduct formed during the reductive metabolism of BrCCl3. Covalent bonding of the proximal histidine to the ring I vinyl group by Osawa, Y, Highet, R J, Bax, A, Pohl, L R

“…The reductive debromination of BrCCl3 by ferrous deoxymyoglobin leads to the covalent bonding of the prosthetic heme to the protein. We have previously shown,…”
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Reductive-oxygenation mechanism of metabolism of carbon tetrachloride to phosgene by cytochrome P-450 by Pohl, L R, Schulick, R D, Highet, R J, George, J W

“…The mechanism of metabolism of carbon tetrachloride (CCl4) to phosgene (COCl2) in rat liver microsomes was investigated. When the oxygen dependency of the…”
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Synthesis and nephrotoxicity of 6-bromo-2,5-dihydroxy-thiophenol by Monks, T J, Highet, R J, Chu, P S, Lau, S S

“…The formation of potentially reactive thiols has been postulated to play a role in the nephrotoxicity caused by a number of glutathione and/or cysteine…”
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Separation of a Newly Identified Contaminant from Commercial 4,5,6,7-Tetrachlorofluorescein by pH-Zone-Refining Countercurrent Chromatography by Weisz, A., Andrzejewski, D., Highet, R. J., Ito, Y.

“…A 5-g sample of commercial 4,5,6,7-tetrachlorofluorescein (TCF) was subjected to pH-zone-refining countercurrent chromatography to separate an unidentified…”
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The use of stable isotopes to identify reactive metabolites and target macromolecules associated with toxicities of halogenated hydrocarbon compounds by Osawa, Y, Highet, R J, Pohl, L R

“…1. Halogenated compounds, such as the inhalation anaesthetics, halothane and enflurane, and the chemicals chloroform, carbon tetrachloride, and…”
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The formation of diglutathionyl dithiocarbonate as a metabolite of chloroform, bromotrichloromethane, and carbon tetrachloride by Pohl, L R, Branchflower, R V, Highet, R J, Martin, J L, Nunn, D S, Monks, T J, George, J W, Hinson, J A

“…One hour after the intraperitoneal administration of CHCl3, CBrCl3, or CCl4 to phenobarbital (PB)-treated rats, hepatic GSH levels decreased to 30, 59, and 88%…”
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Structure of the novel heme adduct formed during the reaction of human hemoglobin with BrCCl3 in red cell lysates by Osawa, Y, Fellows, C S, Meyer, C A, Woods, A, Castoro, J A, Cotter, R J, Wilkins, C L, Highet, R J

“…It was previously shown that the reductive debromination of BrCCl3 to trichloromethyl radical by human hemoglobin leads to formation of dissociable altered…”
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Formation of nontoxic reactive metabolites of p-bromophenol. Identification of a new glutathione conjugate by Monks, T J, Lau, S S, Highet, R J

“…A microsomal metabolite of p-bromophenol was isolated and identified as 6-(glutathion-S-yl)-4-bromocatechol. p-Bromophenol is metabolized in rat liver…”
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3-(glutathion-S-yl)acetaminophen: a biliary metabolite of acetaminophen by Hinson, J A, Monks, T J, Hong, M, Highet, R J, Pohl, L R

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A new class of indolizidine alkaloids from the poison frog, Dendrobates tricolor. X-ray analysis of 8-hydroxy-8-methyl-6-(2'-methylhexylidene)-1-azabicyclo[4.3.0]nonane by Daly, J. W, Tokuyama, T, Fujiwara, T, Highet, R. J, Karle, I. L

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Occurrence of skin alkaloids in non-dendrobatid frogs from Brazil (Bufonidae), Australia (Myobatrachidae) and Madagascar (Mantellinae) by Daly, J W, Highet, R J, Myers, C W

“…Several taxa of small frogs from the southern hemisphere contain alkaloids similar or identical to compounds previously known only from neotropical poison…”
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The chemistry of the antibiotics chrysomycin A and B. Antitumor activity of chrysomycin A by Weiss, U, Yoshihira, K, Highet, R J, White, R J, Wei, T T

“…The yellow antibiotic chrysomycin, isolated in crystalline form in 1955, is found to consist of two closely related components, a major one, chrysomycin A, and…”
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Metasternal gland secretion of the locust tree borer, Megacyllene robiniae (Coleoptera: Cerambycidae) by Wheeler, J W, Abraham, M, Highet, R J, Duffield, R M

“…1. The volatile components of metasternal gland extracts of male and female Megacyllene robiniae have been analyzed by gas chromatography-mass spectroscopy. 2…”
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Metabolism of alpha-naphthoflavone and beta-naphthoflavone by rat liver microsomes and highly purified reconstituted cytochrome P-450 systems by Vyas, K P, Shibata, T, Highet, R J, Yeh, H J, Thomas, P E, Ryan, D E, Levin, W, Jerina, D M

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