Search Results - "Higham, Robert"

Effect of Roflumilast Cream vs Vehicle Cream on Chronic Plaque Psoriasis: The DERMIS-1 and DERMIS-2 Randomized Clinical Trials by Lebwohl, Mark G, Kircik, Leon H, Moore, Angela Y, Stein Gold, Linda, Draelos, Zoe D, Gooderham, Melinda J, Papp, Kim A, Bagel, Jerry, Bhatia, Neal, Del Rosso, James Q, Ferris, Laura K, Green, Lawrence J, Hebert, Adelaide A, Jones, Terry, Kempers, Steven E, Pariser, David M, Yamauchi, Paul S, Zirwas, Matthew, Albrecht, Lorne, Devani, Alim R, Lomaga, Mark, Feng, Amy, Snyder, Scott, Burnett, Patrick, Higham, Robert C, Berk, David R

“…IMPORTANCE: Once-daily roflumilast cream, 0.3%, a potent phosphodiesterase 4 inhibitor, demonstrated efficacy and was well tolerated in a phase 2b trial of…”
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Treatment burden and the perspectives of patients with psoriasis using topical treatments: results from a national survey of adults with psoriasis in the United States by Armstrong, April, Young, Melodie, Seal, Melissa S, Higham, Robert C, Greiling, Teri

“…Topical treatments are the foundation for patients with psoriasis; however, adherence can be limited by patient preferences and treatment burden. The Harris…”
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Pharmacokinetics of Roflumilast Cream in Chronic Plaque Psoriasis: Data from Phase I to Phase III Studies by Thurston, Archie W., Osborne, David W., Snyder, Scott, Higham, Robert C., Burnett, Patrick, Berk, David R.

“…Background Most patients with chronic plaque psoriasis receive topical treatment; however, available options lack a balance of efficacy with long-term safety…”
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Once-daily roflumilast foam 0.3% for scalp and body psoriasis: a randomized, double-blind, vehicle-controlled phase IIb study by Kircik, Leon H, Alonso-Llamazares, Javier, Bhatia, Neal, Bukhalo, Michael, Devani, Alim R, Draelos, Zoe D, DuBois, Janet, Gooderham, Melinda J, Kempers, Steven E, Lain, Edward , Lee, Mark, Moore, Angela, Murrell, Dedee F, Papp, Kim A, Pariser, David M, Sinclair, Rodney , Zirwas, Matthew, Burnett, Patrick, Higham, Robert C, Krupa, David, Berk, David R

“…Abstract Background Scalp psoriasis affects most patients with psoriasis, but it can be difficult to treat. Objectives To evaluate the efficacy and safety of…”
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Efficacy and safety of roflumilast cream for chronic plaque psoriasis with facial/neck and intertriginous area involvement: a post hoc analysis from a randomized controlled trial by Draelos, Zoe D, Adam, David N, Hong, H Chih-Ho, Lebwohl, Mark G, Lynde, Charles W, Nahm, Walter K, Papp, Kim A, Pariser, David M, Stein Gold, Linda, Stewart, Daniel, Higham, Robert C, Berk, David R, Krupa, David, Burnett, Patrick

“…This post hoc analysis evaluated efficacy and safety of roflumilast cream in patients with psoriasis involving the face/neck or intertriginous areas from a…”
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Efficacy of Roflumilast Foam, 0.3%, in Patients With Seborrheic Dermatitis: A Double-blind, Vehicle-Controlled Phase 2a Randomized Clinical Trial by Zirwas, Matthew J, Draelos, Zoe D, DuBois, Janet, Kircik, Leon H, Moore, Angela Y, Stein Gold, Linda, Alonso-Llamazares, Javier, Bukhalo, Michael, Bruce, Suzanne, Eads, Kimmie, Green, Lawrence J, Guenthner, Scott T, Ferris, Laura K, Forman, Seth B, Kempers, Steven E, Lain, Edward, Lynde, Charles W, Pariser, David M, Toth, Darryl P, Yamauchi, Paul S, Higham, Robert C, Krupa, David, Burnett, Patrick, Berk, David R

“…Current topical treatment options for seborrheic dermatitis are limited by efficacy and/or safety. To assess safety and efficacy of roflumilast foam, 0.3%, in…”
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Patient Perspectives on the Prevalence and Burden of Intertriginous Psoriasis: Results from a National Survey of Adults with Psoriasis in the United States by Greiling, Teri, Young, Melodie, Seal, Melissa S., Higham, Robert C., Armstrong, April

“…Introduction A survey was conducted by The Harris Poll on behalf of Arcutis Biotherapeutics in the USA to understand perspectives and burden of patients with…”
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Manifestations and Management of Difficult-to-Treat Psoriasis by Aldredge, Lakshi M, Higham, Robert C

“…ABSTRACTPsoriasis is a common, immune-mediated skin disorder that can manifest as multiple clinical phenotypes. Although psoriasis affecting the scalp, face,…”
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Effect of Roflumilast Cream (ARQ-151) on Itch and Itch-Related Sleep Loss in Adults with Chronic Plaque Psoriasis: Patient-Reported Itch Outcomes of a Phase 2b Trial by Stein Gold, Linda, Alonso-Llamazares, Javier, Draelos, Zoe D., Gooderham, Melinda J., Kempers, Steven E., Kircik, Leon H., Lebwohl, Mark G., Papp, Kim A., Pariser, David M., Toth, Darryl P., Yosipovitch, Gil, Higham, Robert C., Feng, Amy, Berk, David R.

“…Background Itch is the most bothersome symptom reported by patients with psoriasis. Safe and effective treatments for psoriasis that also address itch are…”
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The Proposed PASI-HD Provides More Precise Assessment of Plaque Psoriasis Severity in Anatomical Regions with a Low Area Score by Papp, Kim A., Lebwohl, Mark G., Kircik, Leon H., Pariser, David M., Strober, Bruce, Krueger, Gerald G., Berk, David R., Navale, Lynn, Higham, Robert C.

“…The Psoriasis Area and Severity Index (PASI) is the most widely used clinical measure in clinical trials to assess disease severity of plaque psoriasis…”
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505 - Once-daily roflumilast cream 0.15% for atopic dermatitis: pooled results from INTEGUMENT-1/2 phase 3 trials by Eichenfield, Lawrence F, Boguniewicz, Mark, Simpson, Eric L, Blauvelt, Andrew, Gooderham, Melinda, Lain, Edward, Chu, David H, Higham, Robert C

“…Abstract Introduction Roflumilast cream 0.15% is a selective, highly potent phosphodiesterase 4 inhibitor under investigation as a non-steroidal, once-daily…”
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53025 Roflumilast cream 0.3% in patients with psoriasis: Improvement in patient reported outcomes and pruritus from two pooled phase 3 trials (DERMIS-1/DERMIS-2) by Lebwohl, Mark, Hong, Chih-Ho, Kircik, Leon, Soung, Jennifer, Gooderham, Melinda, Moore, Angela, Del Rosso, James, Turchin, Irina, Krupa, David, Higham, Robert, Berk, David

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53863 Pooled efficacy, patient-reported outcomes, and safety of roflumilast cream 0.15% from the INTEGUMENT-1 and INTEGUMENT-2 phase 3 clinical trials of adults and children with atopic dermatitis by Simpson, Eric, Boguniewicz, Mark, Eichenfield, Lawrence, Gonzales, Mercedes E., Hebert, Adelaide A., Prajapati, Vimal H., Gooderham, Melinda, Krupa, David, Chu, David H., Higham, Robert C., Berk, David R.

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641 - Pooled efficacy, patient-reported outcomes, and safety of roflumilast cream 0.15% from the INTEGUMENT-1 and INTEGUMENT-2 phase 3 trials of adults and children with atopic dermatitis by Simpson, Eric, Boguniewicz, Mark, Eichenfield, Lawrence, Gonzales, Mercedes E, Hebert, Adelaide A, Prajapati, Vimal H, Gooderham, Melinda, Krupa, David, Chu, David H, Higham, Robert C, Berk, David R

“…Abstract Introduction Roflumilast is a selective, highly potent phosphodiesterase 4 inhibitor under investigation as a nonsteroidal, once-daily cream for…”
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639 - Efficacy and safety of once-daily roflumilast cream 0.05% in pediatric patients 2 to 5 years of age with mild to moderate atopic dermatitis (INTEGUMENT-PED): a phase 3 randomized controlled trial by Eichenfield, Lawrence, Browning, John, Funk, Tracy, Gonzalez, Mercedes E, Hebert, Adelaide A, Lee, Mark, Prajapati, Vimal H, Serrao, Rocco, Swanson, Lisa, Higham, Robert, Berk, David

“…Abstract Background Roflumilast is a highly potent phosphodiesterase 4 inhibitor under investigation as a non-steroidal, once-daily cream for atopic dermatitis…”
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42828 Efficacy and safety of roflumilast cream 0.3% in patients with chronic plaque psoriasis: pooled PASI and PASI-HD results from the DERMIS-1 and DERMIS-2 Phase 3 Trials by Papp, Kim, Lebwohl, Mark, Hong, H. Chih-ho, Kircik, Leon, Pariser, David, Strober, Bruce, Krueger, Gerald, Krupa, David, Burnett, Patrick, Berk, David, Higham, Robert

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Assessment of the Vehicle for Roflumilast Cream Compared to a Ceramide-Containing Moisturizing Cream in Mild Eczema by Draelos, Zoe Diana, Higham, Robert C, Osborne, David W, Seal, Melissa S, Burnett, Patrick, Berk, David R

“…Inflammatory dermatologic conditions suitable for topical treatments benefit from a hydrating vehicle that improves the skin barrier without irritation. This…”
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390 Efficacy and safety of roflumilast cream 0.15% in adults and children aged ≥6 years with mild to moderate atopic dermatitis in two phase 3 trials (INTEGUMENT-1 and INTEGUMENT-2) by Simpson, Eric, Eichenfield, Lawrence, Gooderham, Melinda , Gonzalez, Mercedes E, Hebert, Adelaide, Papp, Kim, Prajapati, Vimal, Krupa, David, Burnett, Patrick, Berk, David, Higham, Robert

“…Abstract Roflumilast is a selective, highly potent phosphodie­sterase 4 inhibitor under investigation as a nonsteroidal, once-daily cream for treatment of…”
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33463 Pooled efficacy and safety results from the DERMIS-1 and DERMIS-2 phase 3 trials of once-daily roflumilast cream 0.3% by baseline body surface area by Gold, Linda Stein, Bagel, Jerry, Del Rosso, James, Green, Lawrence J., Lebwohl, Mark, Kircik, Leon H., Feng, Amy, Snyder, Scott, Higham, Robert C., Burnett, Patrick, Berk, David R.

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Patient Perspectives on the Prevalence and Burden of Intertriginous Psoriasis: Results From a National Survey of Adults With Psoriasis in the United States by Greiling, Teri, Young, Melodie, Higham, Robert C, Armstrong, April W

“…N/A…”
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