Search Results - "Higgs, Richard"

Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19: A Randomized Clinical Trial by Gottlieb, Robert L, Nirula, Ajay, Chen, Peter, Boscia, Joseph, Heller, Barry, Morris, Jason, Huhn, Gregory, Cardona, Jose, Mocherla, Bharat, Stosor, Valentina, Shawa, Imad, Kumar, Princy, Adams, Andrew C, Van Naarden, Jacob, Custer, Kenneth L, Durante, Michael, Oakley, Gerard, Schade, Andrew E, Holzer, Timothy R, Ebert, Philip J, Higgs, Richard E, Kallewaard, Nicole L, Sabo, Janelle, Patel, Dipak R, Klekotka, Paul, Shen, Lei, Skovronsky, Daniel M

“…IMPORTANCE: Coronavirus disease 2019 (COVID-19) continues to spread rapidly worldwide. Neutralizing antibodies are a potential treatment for COVID-19…”
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Identification of druggable cancer driver genes amplified across TCGA datasets by Chen, Ying, McGee, Jeremy, Chen, Xianming, Doman, Thompson N, Gong, Xueqian, Zhang, Youyan, Hamm, Nicole, Ma, Xiwen, Higgs, Richard E, Bhagwat, Shripad V, Buchanan, Sean, Peng, Sheng-Bin, Staschke, Kirk A, Yadav, Vipin, Yue, Yong, Kouros-Mehr, Hosein

“…The Cancer Genome Atlas (TCGA) projects have advanced our understanding of the driver mutations, genetic backgrounds, and key pathways activated across cancer…”
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Comparison of baricitinib, upadacitinib, and tofacitinib mediated regulation of cytokine signaling in human leukocyte subpopulations by McInnes, Iain B, Byers, Nicole L, Higgs, Richard E, Lee, Jonathan, Macias, William L, Na, Songqing, Ortmann, Robert A, Rocha, Guilherme, Rooney, Terence P, Wehrman, Thomas, Zhang, Xin, Zuckerman, Steven H, Taylor, Peter C

“…The in vitro pharmacology of baricitinib, upadacitinib, and tofacitinib was evaluated to understand differences among these JAK inhibitors (JAKis) at the…”
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SeedMatchR: identify off-target effects mediated by siRNA seed regions in RNA-seq experiments by Cazares, Tareian, Higgs, Richard E, Wang, Jibo, Ozer, Hatice Gulcin

“…On-target gene knockdown, using siRNA, ideally results from binding fully complementary regions in mRNA transcripts to induce direct cleavage. Off-target siRNA…”
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Characterization of the cytokine storm reflects hyperinflammatory endothelial dysfunction in COVID-19 by Sims, Jonathan T., Krishnan, Venkatesh, Chang, Ching-Yun, Engle, Sarah M., Casalini, Giacomo, Rodgers, George H., Bivi, Nicoletta, Nickoloff, Brian J., Konrad, Robert J., de Bono, Stephanie, Higgs, Richard E., Benschop, Robert J., Ottaviani, Silvia, Cardoso, Anabela, Nirula, Ajay, Corbellino, Mario, Stebbing, Justin

“…Physicians treating patients with coronavirus disease 2019 (COVID-19) increasingly believe that the hyperinflammatory acute stage of COVID-19 results in a…”
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Neutrophil Activation Markers and Rheumatoid Arthritis Treatment Response to the JAK1 /2 Inhibitor Baricitinib by Kuley, Runa, Duvvuri, Bhargavi, Hasnain, Sabeeha, Dow, Ernst R., Koch, Alisa E., Higgs, Richard E., Krishnan, Venkatesh, Lood, Christian

“…Objective Neutrophils play an important role in regulating immune and inflammatory responses in patients with rheumatoid arthritis (RA). We assessed whether…”
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Quantitative Measurement of Intact Alpha-Synuclein Proteoforms from Post-Mortem Control and Parkinson's Disease Brain Tissue by Intact Protein Mass Spectrometry by Kellie, John F., Higgs, Richard E., Ryder, John W., Major, Anthony, Beach, Thomas G., Adler, Charles H., Merchant, Kalpana, Knierman, Michael D.

“…A robust top down proteomics method is presented for profiling alpha-synuclein species from autopsied human frontal cortex brain tissue from Parkinson's cases…”
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A Bayesian gene network reveals insight into the JAK-STAT pathway in systemic lupus erythematosus by Li, Yupeng, Higgs, Richard E, Hoffman, Robert W, Dow, Ernst R, Liu, Xiong, Petri, Michelle, Wallace, Daniel J, Dörner, Thomas, Eastwood, Brian J, Miller, Bradley B, Liu, Yushi

“…Systemic lupus erythematosus (SLE) is a chronic, remitting, and relapsing, inflammatory disease involving multiple organs, which exhibits abnormalities of both…”
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A Randomized, Placebo-Controlled Clinical Trial of Bamlanivimab and Etesevimab Together in High-Risk Ambulatory Patients With COVID-19 and Validation of the Prognostic Value of Persistently High Viral Load by Dougan, Michael, Azizad, Masoud, Mocherla, Bharat, Gottlieb, Robert L, Chen, Peter, Hebert, Corey, Perry, Russell, Boscia, Joseph, Heller, Barry, Morris, Jason, Crystal, Chad, Igbinadolor, Awawu, Huhn, Gregory, Cardona, Jose, Shawa, Imad, Kumar, Princy, Blomkalns, Andra, Adams, Andrew C, Van Naarden, Jacob, Custer, Kenneth L, Knorr, Jack, Oakley, Gerard, Schade, Andrew E, Holzer, Timothy R, Ebert, Philip J, Higgs, Richard E, Sabo, Janelle, Patel, Dipak R, Dabora, Matan C, Williams, Mark, Klekotka, Paul, Shen, Lei, Skovronsky, Daniel M, Nirula, Ajay

“…Abstract Background Based on interim analyses and modeling data, lower doses of bamlanivimab and etesevimab together (700/1400 mg) were investigated to…”
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Sub-setting systemic lupus erythematosus by combined molecular phenotypes defines divergent populations in two phase III randomized trials by Petri, Michelle, Watts, Steven D, Higgs, Richard E, Linnik, Matthew D

“…Heterogeneity of SLE patients in clinical trials remains a challenge for developing new therapies. This study used a combinatorial analysis of four molecular…”
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A systematic examination of anti-drug antibody titer estimation: Applied recommendations by Zhang, Lin, Hodsdon, Michael E., Pottanat, Thomas, Wang, Sihe, Konrad, Robert John, Seta, Nicholas, Higgs, Richard E.

“…Biologic drugs (therapeutic proteins or peptides) have become one of the most important therapeutic modalities over the past few decades. Drug-induced…”
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Assessment and Clinical Relevance of Serum IL-19 Levels in Psoriasis and Atopic Dermatitis Using a Sensitive and Specific Novel Immunoassay by Konrad, Robert J., Higgs, Richard E., Rodgers, George H., Ming, Wenyu, Qian, Yue-Wei, Bivi, Nicoletta, Mack, Justin K., Siegel, Robert W., Nickoloff, Brian J.

“…Because development of reliable biomarkers in psoriasis and atopic dermatitis has lagged behind therapeutic progress, we created a blood-based test to fill the…”
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The anti-SARS-CoV-2 monoclonal antibody bamlanivimab minimally affects the endogenous immune response to COVID-19 vaccination by Benschop, Robert J, Tuttle, Jay L, Zhang, Lin, Poorbaugh, Josh, Kallewaard, Nicole L, Vaillancourt, Peter, Crisp, Melissa, Trinh, Thi Ngoc Vy, Freitas, Joshua J, Beasley, Stephanie, Daniels, Montanea, Haustrup, Natalie, Higgs, Richard E, Nirula, Ajay, Cohen, Myron S, Marovich, Mary

“…As the coronavirus disease 2019 (COVID-19) pandemic evolves and vaccine rollout progresses, the availability and demand for monoclonal antibodies for the…”
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Relationship between gene expression patterns from nasopharyngeal swabs and serum biomarkers in patients hospitalized with COVID-19, following treatment with the neutralizing monoclonal antibody bamlanivimab by Sims, Jonathan T, Poorbaugh, Josh, Chang, Ching-Yun, Holzer, Timothy R, Zhang, Lin, Engle, Sarah M, Beasley, Stephanie, Doman, Thompson N, Naughton, Lynn, Higgs, Richard E, Kallewaard, Nicole, Benschop, Robert J

“…A thorough understanding of a patient's inflammatory response to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is crucial to…”
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Gene Expression and Pharmacodynamic Changes in 1,760 Systemic Lupus Erythematosus Patients From Two Phase III Trials of BAFF Blockade With Tabalumab by Hoffman, Robert W., Merrill, Joan T., Alarcón‐Riquelme, Marta M. E., Petri, Michelle, Dow, Ernst R., Nantz, Eric, Nisenbaum, Laura K., Schroeder, Krista M., Komocsar, Wendy J., Perumal, Narayanan B., Linnik, Matthew D., Airey, David C., Liu, Yushi, Rocha, Guilherme V., Higgs, Richard E.

“…Objective To characterize baseline gene expression and pharmacodynamically induced changes in whole blood gene expression in 1,760 systemic lupus erythematosus…”
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Endogenous Antibody Responses to SARS-CoV-2 in Patients With Mild or Moderate COVID-19 Who Received Bamlanivimab Alone or Bamlanivimab and Etesevimab Together by Zhang, Lin, Poorbaugh, Josh, Dougan, Michael, Chen, Peter, Gottlieb, Robert L, Huhn, Gregory, Beasley, Stephanie, Daniels, Montanea, Ngoc Vy Trinh, Thi, Crisp, Melissa, Freitas, Joshua Joaquin, Vaillancourt, Peter, Patel, Dipak R, Nirula, Ajay, Kallewaard, Nicole L, Higgs, Richard E, Benschop, Robert J

“…Neutralizing monoclonal antibodies (mAbs) to SARS-CoV-2 are clinically efficacious when administered early, decreasing hospitalization and mortality in…”
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Factors which Influence Risk Taking and the Evolution of Social-Identity in Stroke Narratives: A Thematic Synthesis by Higgs, Richard, Soundy, Andrew

“…The disruption of a stroke can impact an individual's sense of social identity. A comprehensive review is required to understand the factors and processes that…”
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Baricitinib-associated changes in global gene expression during a 24-week phase II clinical systemic lupus erythematosus trial implicates a mechanism of action through multiple immune-related pathways by Dörner, Thomas, Tanaka, Yoshiya, Petri, Michelle A, Smolen, Josef S, Wallace, Daniel J, Dow, Ernst R, Higgs, Richard E, Rocha, Guilherme, Crowe, Brenda, Benschop, Robert J, Byers, Nicole L, Silk, Maria E, de Bono, Stephanie, Fantini, Damiano, Hoffman, Robert W

“…ObjectiveTo characterise the molecular pathways impacted by the pharmacologic effects of the Janus kinase (JAK) 1 and JAK2 inhibitor baricitinib in…”
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Insights into adult atopic dermatitis heterogeneity derived from circulating biomarker profiling in patients with moderate‐to‐severe disease by Sims, Jonathan T., Chang, Ching‐Yun, Higgs, Richard E., Engle, Sarah M., Liu, Yushi, Sissons, Sean E., Rodgers, George H., Simpson, Eric L., Silverberg, Jonathan I., Forman, Seth B., Janes, Jonathan M., Colvin, Stephanie C., Guttman‐Yassky, Emma

“…Atopic dermatitis (AD) is a heterogeneous systemic inflammatory skin disease associated with dysregulated immune responses, barrier dysfunction and activated…”
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Evaluation of the Relative Performance of Drug-Induced Skeletal Muscle Injury Biomarkers in Rats by Burch, Peter M, Greg Hall, David, Walker, Elizabeth G, Bracken, William, Giovanelli, Richard, Goldstein, Richard, Higgs, Richard E, King, Nicholas M P, Lane, Pamela, Sauer, John-Michael, Michna, Laura, Muniappa, Nagaraja, Pritt, Michael L, Vlasakova, Katerina, Watson, David E, Wescott, Debra, Zabka, Tanja S, Glaab, Warren E

“…Novel skeletal muscle (SKM) injury biomarkers that have recently been identified may outperform or add value to the conventional SKM injury biomarkers…”
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