Search Results - "Higgs, Josefina"

Chalcone derivatives: synthesis, in vitro and in vivo evaluation of their anti-anxiety, anti-depression and analgesic effects by Higgs, Josefina, Wasowski, Cristina, Marcos, Alejandra, Jukič, Marko, Paván, Carlos Humberto, Gobec, Stanislav, de Tezanos Pinto, Felicitas, Colettis, Natalia, Marder, Mariel

“…Anxiety disorders, depression and pain are highly prevalent pathologies. Their pharmacotherapy is associated with unwanted side effects; hence there is a…”
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3,3-Dibromoflavanone, a synthetic flavonoid derivative for pain management with antidepressant-like effects and fewer side effects than those of morphine in mice by Colettis, Natalia, Higgs, Josefina, Wasowski, Cristina, Knez, Damijan, Gobec, Stanislav, Pastore, Valentina, Marder, Mariel

“…In the pursuit of new lead compounds with fewer side effects than opioids, the novel synthetic phytochemical core, 3,3-dibromoflavanone (3,3-DBF), has emerged…”
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Stereoselective Activity of 1‑Propargyl-4-styrylpiperidine-like Analogues That Can Discriminate between Monoamine Oxidase Isoforms A and B by Knez, Damijan, Colettis, Natalia, Iacovino, Luca G, Sova, Matej, Pišlar, Anja, Konc, Janez, Lešnik, Samo, Higgs, Josefina, Kamecki, Fabiola, Mangialavori, Irene, Dolšak, Ana, Žakelj, Simon, Trontelj, Jurij, Kos, Janko, Binda, Claudia, Marder, Mariel, Gobec, Stanislav

“…The resurgence of interest in monoamine oxidases (MAOs) has been fueled by recent correlations of this enzymatic activity with cardiovascular, neurological,…”
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In vitro binding affinities of a series of flavonoids for μ-opioid receptors. Antinociceptive effect of the synthetic flavonoid 3,3-dibromoflavanone in mice by Higgs, Josefina, Wasowski, Cristina, Loscalzo, Leonardo M., Marder, Mariel

“…The pharmacotherapy for the treatment of pain is an active area of investigation. There are effective drugs to treat this problem, but there is also a need to…”
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Multitarget 2′-hydroxychalcones as potential drugs for the treatment of neurodegenerative disorders and their comorbidities by Kamecki, Fabiola, Knez, Damijan, Carvalho, Diego, Marcucci, Carolina, Rademacher, Marina, Higgs, Josefina, Žakelj, Simon, Marcos, Alejandra, de Tezanos Pinto, Felicitas, Abin-Carriquiry, Juan Andrés, Gobec, Stanislav, Colettis, Natalia, Marder, Mariel

“…The complex nature of neurodegenerative diseases (NDDs), such as Alzheimer's disease (AD) and Parkinson's disease (PD) calls for multidirectional treatment…”
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N-propyl-2,2-diphenyl-2-hydroxyacetamide, a novel α-hydroxyamide with anticonvulsant, anxiolytic and antidepressant-like effects that inhibits voltage-gated sodium channels by Pastore, Valentina, Wasowski, Cristina, Martin, Pedro, Enrique, Andrea, Higgs, Josefina, Bruno-Blanch, Luis E., Milesi, Veronica, Marder, Mariel

“…In patients with epilepsy, anxiety and depression are the most frequent psychiatric comorbidities but they often remain unrecognized and untreated. We report…”
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Novel sulfamides and sulfamates derived from amino esters: Synthetic studies and anticonvulsant activity by Villalba, Maria L., Enrique, Andrea V., Higgs, Josefina, Castaño, Rocío A., Goicoechea, Sofía, Taborda, Facundo D., Gavernet, Luciana, Lick, Ileana D, Marder, Mariel, Bruno Blanch, Luis E.

“…We report herein the design and optimization of a novel series of sulfamides and sulfamates derived from amino esters with anticonvulsant properties. The…”
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Chronic Intraperitoneal and Oral Treatments with Hesperidin Induce Central Nervous System Effects in Mice by Wasowski, Cristina, Loscalzo, Leonardo M, Higgs, Josefina, Marder, Mariel

“…Hesperidin (HN) is a flavanone glycoside abundantly found in citrus fruits. This flavonoid mediated central nervous system activity following intraperitoneal…”
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A synthetic bioisoster of trimethadione and phenytoin elicits anticonvulsant effect, protects the brain oxidative damage produced by seizures and exerts antidepressant action in mice by Pastore, Valentina, Wasowski, Cristina, Higgs, Josefina, Mangialavori, Irene C, Bruno-Blanch, Luis E, Marder, Mariel

“…Abstract Epilepsy is recognized as one of the most common and serious neurological disorder affecting 1–2% of the world׳s population. The present study…”
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Multitarget 2′-hydroxychalcones as potential drugs for the treatment of neurodegenerative disorders and their comorbidities by Kamecki, Fabiola, Knez, Damijan, Carvalho, Diego, Marcucci, Carolina, Rademacher, Marina, Higgs, Josefina, Žakelj, Simon, Marcos, Alejandra, de Tezanos Pinto, Felicitas, Abin-Carriquiry, Juan Andrés, Gobec, Stanislav, Colettis, Natalia, Marder, Mariel

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