Search Results - "Higgs, E A"

The discovery of nitric oxide and its role in vascular biology by Moncada, S, Higgs, E A

“…Nitric oxide (NO) is a relative newcomer to pharmacology, as the paper which initiated the field was published only 25 years ago. Nevertheless its impact is…”
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Molecular mechanisms and therapeutic strategies related to nitric oxide by Moncada, S, Higgs, E A

“…The formation of nitric oxide (NO) from L-arginine is now recognized as a ubiquitous biochemical pathway involved in the regulation of the cardiovascular,…”
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Endogenous nitric oxide: physiology, pathology and clinical relevance by Moncada, S, Higgs, E A

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Nitric oxide: physiology, pathophysiology, and pharmacology by Moncada, S, Palmer, R M, Higgs, E A

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Nitric oxide and the vascular endothelium by Moncada, S, Higgs, E A

“…The vascular endothelium synthesises the vasodilator and anti-aggregatory mediator nitric oxide (NO) from L-arginine. This action is catalysed by the action of…”
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The Discovery of Nitric Oxide as the Endogenous Nitrovasodilator by MONCADA, SALVADOR, PALMER, RICHARD M. J, HIGGS, E ANNIE

“…Endothelium-derived relaxing factor (EDRF) is a labile humoral agent released by vascular endotheHum that mediates the relaxation induced by some vasodilators,…”
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Subcellular localization of nitric oxide synthase in the cerebral ventricular system, subfornical organ, area postrema, and blood vessels of the rat brain by Rodrigo, J., Riveros-Moreno, V., Bentura, M.L., Uttenthal, L.O., Higgs, E.A., Fernandez, A.P., Polak, J.M., Moncada, S., Martínez-Murillo, R.

“…The distribution of neuronal nitric oxide synthase (nNOS) has been studied in the more rostral portion of the lateral ventricle, subfornical organ, area…”
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Relationship between prostacyclin and nitric oxide in the thrombotic process by Moncada, S, Palmer, R M, Higgs, E A

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Biosynthesis of nitric oxide from L-arginine. A pathway for the regulation of cell function and communication by Moncada, S, Palmer, R M, Higgs, E A

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The biological significance of nitric oxide formation from L-arginine by Moncada, S, Palmer, R M, Higgs, E A

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Metabolism of arachidonic acid by Moncada, S, Higgs, E A

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Differential formation of prostacyclin (PGX or PGI2) by layers of the arterial wall. An explanation for the anti-thrombotic properties of vascular endothelium by Moncada, S, Herman, A G, Higgs, E A, Vane, J R

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Prostaglandins and thromboxanes from fatty acids by Higgs, E A, Moncada, S, Vane, J R

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Characterization and biological significance of endothelium-derived relaxing factor by Moncada, S, Higgs, E A, Palmer, R M

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Effect of prostacyclin (PGI2) on platelet adhesion to rabbit arterial subendothelium by Higgs, E A, Moncada, S, Vane, J R, Caen, J P, Michel, H, Tobelem, G

“…The effect of prostacyclin on platelet aggregation and adhesion was investigated in everted pieces of rabbit abdominal aorta, from which the endothelium had…”
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Effects of intravenous infusion of prostacyclin (PGI2) in man by O'Grady, J, Warrington, S, Moti, M J, Bunting, S, Flower, R, Fowle, A S, Higgs, E A, Moncada, S

“…Prostacyclin infused intravenously in human volunteers induces ex vivo inhibition of platelet aggregation, tachycardia and hypotension. The inhibition of…”
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PROSTACYCLIN (PGI2) INHIBITS THE FORMATION OF PLATELET THROMBI IN ARTERIOLES AND VENULES OF THE HAMSTER CHEEK POUCH by HIGGS, E.A., HIGGS, G.A., MONCADA, S., VANE, J.R.

“…1 Isolated rings of hamster aorta produced an unstable substance which inhibited platelet aggregation in vitro and had the same characteristics as…”
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The endogenous nitrovasodilator produced by the vascular endothelium by Dusting, G J, Macdonald, P S, Higgs, E A, Moncada, S

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Human arterial and venous tissues generate prostacyclin (prostaglandin x), a potent inhibitor of platelet aggregation by Moncada, S, Higgs, E A, Vane, J R

“…Fresh rings of arteries and veins obtained from surgical specimens generated an unstable substance, prostacyclin (prostaglandinx, [P.G.X]) WHICH IS A POTENT…”
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Arachidonate metabolism in blood cells and the vessel wall by Moncada, S, Higgs, E A

“…Arachidonic acid (AA) is metabolized by the cyclo-oxygenase and the lipoxygenase pathways to give a number of products, some of which have potent and sometimes…”
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