Search Results - "Higginson, Daniel S"

Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes by Riaz, Nadeem, Blecua, Pedro, Lim, Raymond S., Shen, Ronglai, Higginson, Daniel S., Weinhold, Nils, Norton, Larry, Weigelt, Britta, Powell, Simon N., Reis-Filho, Jorge S.

“…BRCA1  and  BRCA2 are involved in homologous recombination (HR) DNA repair and are germ-line cancer pre-disposition genes that result in a syndrome of…”
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Survival Trends After Surgery for Spinal Metastatic Tumors: 20-Year Cancer Center Experience by Rothrock, Robert J, Barzilai, Ori, Reiner, Anne S, Lis, Eric, Schmitt, Adam M, Higginson, Daniel S, Yamada, Yoshiya, Bilsky, Mark H, Laufer, Ilya

“…Abstract BACKGROUND Over the last 2 decades, advances in systemic therapy have increased the expected overall survival for patients with cancer. It is unclear…”
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Exponential Increase in Relative Biological Effectiveness Along Distal Edge of a Proton Bragg Peak as Measured by Deoxyribonucleic Acid Double-Strand Breaks by Cuaron, John J., MD, Chang, Chang, PhD, Lovelock, Michael, PhD, Higginson, Daniel S., MD, Mah, Dennis, PhD, Cahlon, Oren, MD, Powell, Simon, MD, PhD

“…Purpose To quantify the relative biological effectiveness (RBE) of the distal edge of the proton Bragg peak, using an in vitro assay of DNA double-strand…”
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Bilirubin and glutathione have complementary antioxidant and cytoprotective roles by Sedlak, Thomas W, Saleh, Masoumeh, Higginson, Daniel S, Paul, Bindu D, Juluri, Krishna R, Snyder, Solomon H

“…Glutathione (GSH) and bilirubin are prominent endogenous antioxidant cytoprotectants. Despite tissue levels that are thousands of times lower than GSH,…”
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The Implications of Genetic Testing on Radiation Therapy Decisions: A Guide for Radiation Oncologists by Bergom, Carmen, West, Catharine M., Higginson, Daniel S., Abazeed, Mohamed E., Arun, Banu, Bentzen, Soren M., Bernstein, Jonine L., Evans, Jaden D., Gerber, Naamit K., Kerns, Sarah L., Keen, Judy, Litton, Jennifer K., Reiner, Anne S., Riaz, Nadeem, Rosenstein, Barry S., Sawakuchi, Gabriel O., Shaitelman, Simona F., Powell, Simon N., Woodward, Wendy A.

“…The advent of affordable and rapid next-generation DNA sequencing technology, along with the US Supreme Court ruling invalidating gene patents, has led to a…”
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Measuring nonhomologous end-joining, homologous recombination and alternative end-joining simultaneously at an endogenous locus in any transfectable human cell by Hussain, Suleman S, Majumdar, Rahul, Moore, Grace M, Narang, Himanshi, Buechelmaier, Erika S, Bazil, Maximilian J, Ravindran, Pavithran T, Leeman, Jonathan E, Li, Yi, Jalan, Manisha, Anderson, Kyrie S, Farina, Andrea, Soni, Rekha, Mohibullah, Neeman, Hamzic, Edin, Rong-Mullins, Xiaoqing, Sifuentes, Christopher, Damerla, Rama R, Viale, Agnes, Powell, Simon N, Higginson, Daniel S

“…Abstract Double strand break (DSB) repair primarily occurs through 3 pathways: non-homologous end-joining (NHEJ), alternative end-joining (Alt-EJ), and…”
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Genomic Signatures in HPV-Associated Tumors by Hussain, Suleman S, Lundine, Devon, Leeman, Jonathan E, Higginson, Daniel S

“…Papillomaviruses dysregulate the G1/S cell cycle transition in order to promote DNA synthesis in S phase, which is a requirement for viral replication. The…”
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Treatment of dedifferentiated chordoma: a retrospective study from a large volume cancer center by Nachwalter, Ryan N., Rothrock, Robert J., Katsoulakis, Evangelina, Gounder, Mrinal M., Boland, Patrick J., Bilsky, Mark H., Laufer, Ilya, Schmitt, Adam M., Yamada, Yoshiya, Higginson, Daniel S.

“…Objective Dedifferentiated chordomas (DC) are genetically and clinically distinct from conventional chordomas (CC), exhibiting frequent SMARCB1 alterations and…”
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Stereotactic body radiotherapy (SBRT): Technological innovation and application in gynecologic oncology by Higginson, Daniel S, Morris, David E, Jones, Ellen L, Clarke-Pearson, Daniel, Varia, Mahesh A

“…Abstract Objectives Stereotactic body radiotherapy (SBRT) is a novel form of noninvasive, highly conformal radiation treatment that delivers a high dose to…”
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Myositis following spine radiosurgery for metastatic disease: a case series by Lockney, Dennis T, Jia, Angela Y, Lis, Eric, Lockney, Natalie A, Liu, Chengbao, Hopkins, Benjamin, Higginson, Daniel S, Yamada, Yoshiya, Laufer, Ilya, Bilsky, Mark, Schmitt, Adam M

“…OBJECTIVE Spinal stereotactic body radiation therapy (SBRT) has emerged as an attractive method to deliver high doses of radiation to oligometastatic spinal…”
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Early Detection of Leptomeningeal Metastases Among Patients Undergoing Spinal Stereotactic Radiosurgery by Freret, Morgan E., Wijetunga, N. Ari, Shamseddine, Achraf A., Higginson, Daniel S., Schmitt, Adam M., Yamada, Yoshiya, Lis, Eric, Boire, Adrienne, Yang, Jonathan T., Xu, Amy J.

“…The management of patients with advanced solid malignancies increasingly uses stereotactic body radiation therapy (SBRT). Advanced cancer patients are at risk…”
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HIV Gag Mimics the Tsg101-Recruiting Activity of the Human Hrs Protein by Pornillos, Owen, Higginson, Daniel S., Stray, Kirsten M., Fisher, Robert D., Garrus, Jennifer E., Payne, Marielle, He, Gong-Ping, Wang, Hubert E., Morham, Scott G., Sundquist, Wesley I.

“…The HIV-1 Gag protein recruits the cellular factor Tsg101 to facilitate the final stages of virus budding. A conserved P(S/T)AP tetrapeptide motif within Gag…”
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Clinical Outcomes of Dose-Escalated Hypofractionated External Beam Radiation Therapy (5 Gy × 5 Fractions) for Spine Metastasis by Shin, Jacob Y., Mathis, Noah J., Wijetunga, Neil Ari, Yerramilli, Divya, Higginson, Daniel S., Schmitt, Adam M., Gomez, Daniel R., Yamada, Yoshiya J., Yang, Jonathan T.

“…The objective of this study was to determine the toxicities and outcomes of patients with spinal metastasis treated with external beam radiation therapy (EBRT)…”
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Structure and Ubiquitin Binding of the Ubiquitin-interacting Motif by Fisher, Robert D., Wang, Bin, Alam, Steven L., Higginson, Daniel S., Robinson, Howard, Sundquist, Wesley I., Hill, Christopher P.

“…Ubiquitylation is used to target proteins into a large number of different biological processes including proteasomal degradation, endocytosis, virus budding,…”
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The Impact of Local and Regional Disease Extent on Overall Survival in Patients With Advanced Stage IIIB/IV Non-Small Cell Lung Carcinoma by Higginson, Daniel S., MD, Chen, Ronald C., MD, MPH, Tracton, Gregg, BSE, Morris, David E., MD, Halle, Jan, MD, Rosenman, Julian G., MD, Stefanescu, Mihaela, Pham, Erica, Socinski, Mark A., MD, Marks, Lawrence B., MD

“…Purpose Patients with advanced stage IIIB or stage IV non-small cell lung carcinoma are typically treated with initial platinum-based chemotherapy. A variety…”
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Integrating Evidence-Based Medicine for Treatment of Spinal Metastases Into a Decision Framework: Neurologic, Oncologic, Mechanicals Stability, and Systemic Disease by Barzilai, Ori, Laufer, Ilya, Yamada, Yoshiya, Higginson, Daniel S, Schmitt, Adam M, Lis, Eric, Bilsky, Mark H

“…Patients with cancer are frequently affected by spinal metastases. Treatment is palliative, with the principle goals of pain relief, preservation of neurologic…”
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Should Postoperative Radiation for Long Bone Metastases Cover Part or All of the Orthopedic Hardware? Results of a Large Retrospective Analysis by Rosen, Daniel B., Haseltine, Justin M., Bartelstein, Meredith, Flynn, Jessica R., Zhang, Zhigang, Kohutek, Zachary A., Yamada, Yoshiya, Schmitt, Adam, Higginson, Daniel S., Vaynrub, Maksim, Yang, Jonathan T., Gillespie, Erin F.

“…For patients with long bone metastases who undergo orthopedic stabilization surgery followed by radiotherapy (RT), it is unclear what extent of hardware…”
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Neuronal growth and survival mediated by eIF5A, a polyamine-modified translation initiation factor by Huang, Yunfei, Higginson, Daniel S, Hester, Lynda, Park, Myung Hee, Snyder, Solomon H

“…Eukaryotic translation initiation factor 5A (eIF5A), the only known protein containing the polyamine-derived amino acid hypusine, modulates protein synthesis…”
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Replacing 30 Gy in 10 fractions with stereotactic body radiation therapy for bone metastases: A large multi-site single institution experience 2016–2018 by Gillespie, Erin F., Lapen, Kaitlyn, Wang, Diana G., Wijetunga, N., Pastrana, Gerri L., Kollmeier, Marisa A., Yamada, Josh, Schmitt, Adam M., Higginson, Daniel S., Vaynrub, Max, Santos Martin, Ernesto, Xu, Amy J., Jillian Tsai, C., Yerramilli, Divya, Cahlon, Oren, Jonathan Yang, T.

“…•Contemporary trends in radiation technique and fractionation for bone metastases at a large academic center with a specialized metastatic…”
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Elective Regional Nodal Irradiation in Patients With Early-Stage Breast Cancer by Xie, Liyi, MD, Higginson, Daniel S., MD, Marks, Lawrence B., MD

“…Elective regional lymph nodal irradiation is controversial in patients with early stage breast cancer. Under the “Halstedian” model of tumor progression,…”
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