Search Results - "Higgins, P N"

Intellectual abilities in tuberous sclerosis complex: risk factors and correlates from the Tuberous Sclerosis 2000 Study by Bolton, P F, Clifford, M, Tye, C, Maclean, C, Humphrey, A, le Maréchal, K, Higgins, J N P, Neville, B G R, Rijsdjik, F, Yates, J R W

“…Tuberous sclerosis complex (TSC) is associated with intellectual disability, but the risk pathways are poorly understood. The Tuberous Sclerosis 2000 Study is…”
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Perfusion CT helps decision making for thrombolysis when there is no clear time of onset by Hellier, K D, Hampton, J L, Guadagno, J V, Higgins, N P, Antoun, N M, Day, D J, Gillard, J H, Warburton, E A, Baron, J-C

“…Current guidelines on thrombolysis post stroke with recombinant tissue plasminogen activator (rt-PA) exclude its use where time of onset is unknown, thus…”
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Idiopathic intracranial hypertension: 12 cases treated by venous sinus stenting by Higgins, J N P, Cousins, C, Owler, B K, Sarkies, N, Pickard, J D

“…Background: The high pressures documented in the intracranial venous sinuses in idiopathic intracranial hypertension (IIH) could be the result of focal…”
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Surveying a supercoil domain by using the gamma delta resolution system in Salmonella typhimurium by Higgins, N P, Yang, X, Fu, Q, Roth, J R

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Intractable headache after excision of an acoustic neuroma treated by stent revascularisation of the sigmoid sinus by Higgins, J. N. P., Pickard, John D.

“…Abstract A 47 year old man developed severe headaches after resection of an acoustic neuroma ipsilateral to non dominant venous drainage. CSF pressures were…”
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The F plasmid CcdB protein induces efficient ATP-dependent DNA cleavage by gyrase by Bernard, P, Kézdy, K E, Van Melderen, L, Steyaert, J, Wyns, L, Pato, M L, Higgins, P N, Couturier, M

“…DNA topoisomerases perform essential roles in DNA replication, gene transcription, and chromosome segregation. Recently, we identified a new type of…”
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The Tuberous Sclerosis 2000 Study: presentation, initial assessments and implications for diagnosis and management by Yates, John RW, MacLean, Cathy, Higgins, J Nicholas P, Humphrey, Ayla, le Maréchal, Kate, Clifford, Michelle, Carcani-Rathwell, Iris, Sampson, Julian R, Bolton, Patrick F

“…Aims The Tuberous Sclerosis 2000 Study is the first comprehensive longitudinal study of tuberous sclerosis (TS) and aims to identify factors that determine…”
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Transcription induces a supercoil domain barrier in bacteriophage Mu by Scheirer, Katherine E, Higgins, N.Patrick

“…In enteric bacteria, chromosomes are partitioned into domains that exhibit restricted supercoil movement. The most common domain barrier detected by γδ…”
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Positive and negative regulation of the Mu operator by Mu repressor and Escherichia coli integration host factor by Krause, H M, Higgins, N P

“…Bacteriophage Mu utilizes two converging promoters to regulate the lytic and lysogenic pathways. Messenger RNA encoding the repressor gene is synthesized…”
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Characterization of Mu prophage lacking the central strong gyrase binding site: localization of the block in replication by Pato, M L, Karlok, M, Wall, C, Higgins, N P

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Temperature-sensitive mutations in the bacteriophage Mu c repressor locate a 63-amino-acid DNA-binding domain by VOGEL, J. L, ZHU JUAN LI, HOWE, M. M, TOUSSAINT, A, HIGGINS, N. P

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Supercoiling and integration host factor change the DNA conformation and alter the flow of convergent transcription in phage Mu by Higgins, N P, Collier, D A, Kilpatrick, M W, Krause, H M

“…Transcription of bacteriophage Mu is modulated by its repressor, by negative supercoiling, and by the Escherichia coli protein integration host factor (IHF)…”
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Packaging Specific Segments of the Salmonella Chromosome With Locked-in Mud-P22 Prophages by Youderian, P, Sugiono, P, Brewer, K. L, Higgins, N. P, Elliott, T

“…Hybrid genetic elements, Mud-P and Mud-Q (collectively, Mud-P22s), have been constructed that carry two-thirds of the temperate Salmonella phage P22 genome…”
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Subunit-specific phenotypes of Salmonella typhimurium HU mutants by HILLYARD, D. R, EDLUND, M, HUGHES, K. T, MARSH, M, HIGGINS, N. P

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C-Terminal Deletions Can Suppress Temperature-Sensitive Mutations and Change Dominance in the Phage Mu Repressor by Vogel, J. L, Geuskens, V, Desmet, L, Higgins, N. P, Toussaint, A

“…Mutations in an N-terminal 70-amino acid domain of bacteriophage Mu's repressor cause temperature-sensitive DNA-binding activity. Surprisingly, amber mutations…”
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Differential activity of a transposable element in Escherichia coli colonies by SHAPIRO, J. A, HIGGINS, N. P

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A DNA Gyrase-Binding Site at the Center of the Bacteriophage Mu Genome is Required for Efficient Replicative Transposition by Pato, Martin L., Howe, Martha M., Higgins, N. Patrick

“…We have discovered a centrally located site that is required for efficient replication of bacteriophage Mu DNA and identified it as a strong DNA gyrase-binding…”
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'Muprints' of the lac operon demonstrate physiological control over the randomness of in vivo transposition by Wang, X, Higgins, N P

“…A method called Muprinting has been developed that uses PCR to generate a detailed picture of the bacteriophage Mu transposition sites in chosen domains of the…”
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Topoisomerase mutants and physiological conditions control supercoiling and Z-DNA formation in vivo by JAWORSKI, A, HIGGINS, N. P, WELLS, R. D, ZACHARIAS, W

“…The influence of topoisomerase I and gyrase mutations in Escherichia coli on the supercoiled density of recombinant plasmids and the stability of left-handed…”
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Transcription-Induced Barriers to Supercoil Diffusion in the Salmonella typhimurium Chromosome by Deng, Shuang, Stein, Richard A., Higgins, N. Patrick, Gottesman, Susan

“…Transcription and replication both influence and are influenced by superhelical changes in DNA. Explaining how supercoil movement is channeled in living…”
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