Search Results - "Higgins, Linda S"

Basic Mechanisms Responsible for Osteolytic and Osteoblastic Bone Metastases by GUISE, Theresa A, MOHAMMAD, Khalid S, CHIRGWIN, John M, CLINES, Gregory, STEBBINS, Elizabeth G, WONG, Darren H, HIGGINS, Linda S, VESSELLA, Robert, COREY, Eva, PADALECKI, Susan, SUVA, Larry

“…Certain solid tumors metastasize to bone and cause osteolysis and abnormal new bone formation. The respective phenotypes of dysregulated bone destruction and…”
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Mitogen-activated protein kinase phosphatase-1 is a mediator of breast cancer chemoresistance by SMALL, George W, SHI, Yue Y, HIGGINS, Linda S, ORLOWSKIL, Robert Z

“…The mitogen-activated protein kinase (MAPK) phosphatase (MKP)-1 is overexpressed in a large proportion of breast cancers, and in some systems interferes with…”
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Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors by Navas, Tony A., Mohindru, Mani, Estes, Myka, Ma, Jing Ying, Sokol, Lubomir, Pahanish, Perry, Parmar, Simrit, Haghnazari, Edwin, Zhou, Li, Collins, Robert, Kerr, Irene, Nguyen, Aaron N., Xu, Yin, Platanias, Leonidas C., List, Alan A., Higgins, Linda S., Verma, Amit

“…The myelodysplastic syndromes (MDSs) are collections of heterogeneous hematologic diseases characterized by refractory cytopenias as a result of ineffective…”
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Role of the p38 mitogen-activated protein kinase pathway in the generation of arsenic trioxide-dependent cellular responses by Giafis, Nick, Katsoulidis, Efstratios, Sassano, Antonella, Tallman, Martin S, Higgins, Linda S, Nebreda, Angel R, Davis, Roger J, Platanias, Leonidas C

“…Arsenic trioxide (As(2)O(3)) induces differentiation and apoptosis of leukemic cells in vitro and in vivo, but the precise mechanisms that mediate such effects…”
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p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells by HIDESHIMA, Teru, PODAR, Klaus, NGUYEN, Aaron N, NAVAS, Tony, MUNSHI, Nikhil C, RICHARDSON, Paul G, HIGGINS, Linda S, ANDERSON, Kenneth C, CHAUHAN, Dharminder, ISHITSUKA, Kenji, MITSIADES, Constantine, TAI, Yu-Tzu, HAMASAKI, Makoto, RAJE, Noopur, HIDESHIMA, Hiromasa, SCHREINER, George

“…Although PS-341 (bortezomib) is a promising agent to improve multiple myeloma (MM) patient outcome, 65% of patients with relapsed and refractory disease do not…”
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Transforming Growth Factor β Receptor I Kinase Inhibitor Down-Regulates Cytokine Secretion and Multiple Myeloma Cell Growth in the Bone Marrow Microenvironment by HAYASHI, Toshiaki, HIDESHIMA, Teru, MURPHY, Alison, CHAUHAN, Dharminder, HIGGINS, Linda S, ANDERSON, Kenneth C, NGUYEN, Aaron N, MUNOZ, Olivier, PODAR, Klaus, HAMASAKI, Makoto, ISHITSUKA, Kenji, YASUI, Hiroshi, RICHARDSON, Paul, CHAKRAVARTY, Sarvajit

“…Purpose: Transforming growth factors (TGFs) have pleiotropic biological effects on tumor cells and their environment. In multiple myeloma (MM), we have…”
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Role of p38 mitogen-activated protein kinase in ozone-induced airway hyperresponsiveness and inflammation by Williams, Alison S., Issa, Razao, Durham, Andrew, Leung, Sum-Yee, Kapoun, Ann, Medicherla, Satyanarayana, Higgins, Linda S., Adcock, Ian M., Chung, Kian Fan

“…Ozone is a potent oxidant and causes airway hyperresponsiveness and neutrophilia. To determine the role of p38 mitogen-activated protein kinase (MAPK)…”
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β-Amyloid Precursor Protein Transgenic Mice That Harbor Diffuse Aβ Deposits but Do Not Form Plaques Show Increased Ischemic Vulnerability: Role of Inflammation by Koistinaho, Milla, Kettunen, Mikko I., Goldsteins, Gundars, Keinänen, Riitta, Salminen, Antero, Ort, Michael, Bures, Jan, Liu, David, Kauppinen, Risto A., Higgins, Linda S., Koistinaho, Jari

“…β-amyloid (Aβ), derived form the β-amyloid precursor protein (APP), is important for the pathogenesis of Alzheimer's disease (AD), which is characterized by…”
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Can a selective PPARγ modulator improve glycemic control in patients with type 2 diabetes with fewer side effects compared with pioglitazone? by DePaoli, Alex M, Higgins, Linda S, Henry, Robert R, Mantzoros, Christos, Dunn, Fredrick L

“…INT131 besylate is a potent, nonthiazolidinedione, selective peroxisome proliferator-activated receptor γ (PPARγ) modulator (SPPARM) designed to improve…”
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Editorial Expression of Concern: p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells by Hideshima, Teru, Podar, Klaus, Chauhan, Dharminder, Ishitsuka, Kenji, Mitsiades, Constantine, Tai, Yu-Tzu, Hamasaki, Makoto, Raje, Noopur, Hideshima, Hiromasa, Schreiner, George, Nguyen, Aaron N., Navas, Tony, Munshi, Nikhil C., Richardson, Paul G., Higgins, Linda S., Anderson, Kenneth C.

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Selective modulation of PPARγ activity can lower plasma glucose without typical thiazolidinedione side-effects in patients with Type 2 diabetes by Dunn, Fredrick L, Higgins, Linda S, Fredrickson, Jill, DePaoli, Alex M

“…Abstract Objective INT131 besylate is a potent non-thiazolidinedione selective peroxisome proliferator-activated receptor γ (PPARγ)  modulator (SPPARM)…”
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Inhibition of the TGF-β receptor I kinase promotes hematopoiesis in MDS by Zhou, Li, Nguyen, Aaron N., Sohal, Davendra, Ying Ma, Jing, Pahanish, Perry, Gundabolu, Krishna, Hayman, Josh, Chubak, Adam, Mo, Yongkai, Bhagat, Tushar D., Das, Bhaskar, Kapoun, Ann M., Navas, Tony A., Parmar, Simrit, Kambhampati, Suman, Pellagatti, Andrea, Braunchweig, Ira, Zhang, Ying, Wickrema, Amittha, Medicherla, Satyanarayana, Boultwood, Jacqueline, Platanias, Leonidas C., Higgins, Linda S., List, Alan F., Bitzer, Markus, Verma, Amit

“…MDS is characterized by ineffective hematopoiesis that leads to peripheral cytopenias. Development of effective treatments has been impeded by limited insight…”
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SD-208, a novel transforming growth factor β receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo by UHL, Martin, AULWURM, Steffen, MURPHY, Alison, WONG, Darren H, WICK, Wolfgang, HIGGINS, Linda S, WELLER, Michael, WISCHHUSEN, Jörg, WEILER, Markus, JING YING MA, ALMIREZ, Ramona, MANGADU, Ruban, LIU, Yu-Wang, PLATTEN, Michael, HERRLINGER, Ulrich

“…The cytokine transforming growth factor (TGF)-beta, by virtue of its immunosuppressive and promigratory properties, has become a major target for the…”
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Inhibition of transforming growth factor beta signaling reduces pancreatic adenocarcinoma growth and invasiveness by Gaspar, Nicholas J, Li, Lingyun, Kapoun, Ann M, Medicherla, Satyanarayana, Reddy, Mamatha, Li, Georgia, O'Young, Gilbert, Quon, Diana, Henson, Margaret, Damm, Deborah L, Muiru, Gladys T, Murphy, Alison, Higgins, Linda S, Chakravarty, Sarvajit, Wong, Darren H

“…Transforming growth factor beta (TGFbeta) is a pleiotropic factor that regulates cell proliferation, angiogenesis, metastasis, and immune suppression…”
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Selective p38α mitogen-activated protein kinase inhibitor attenuates lung inflammation and fibrosis in IL-13 transgenic mouse model of asthma by Ma, Jing Ying, Medicherla, Satyanarayana, Kerr, Irene, Mangadu, Ruban, Protter, Andrew A, Higgins, Linda S

“…p38 Mitogen-activated protein kinase (MAPK) plays a critical role in the activation of inflammatory cells. We investigated the anti-inflammatory effects of a…”
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The Development of INT131 as a Selective PPAR Modulator: Approach to a Safer Insulin Sensitizer by Higgins, Linda S., Mantzoros, Christos S.

“…INT131 (formerly T0903131, T131, AMG131) is a potent non-thiazolidinedione (TZD) selective peroxisome proliferator-activated receptor modulator (SPPARM)…”
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Inhibiting TGF-beta signaling restores immune surveillance in the SMA-560 glioma model by Tran, Thomas-Toan, Uhl, Martin, Ma, Jing Ying, Janssen, Lisa, Sriram, Venkataraman, Aulwurm, Steffen, Kerr, Irene, Lam, Andrew, Webb, Heather K, Kapoun, Ann M, Kizer, Darin E, McEnroe, Glenn, Hart, Barry, Axon, Jonathan, Murphy, Alison, Chakravarty, Sarvajit, Dugar, Sundeep, Protter, Andrew A, Higgins, Linda S, Wick, Wolfgang, Weller, Michael, Wong, Darren H

“…Transforming growth factor-beta (TGF-beta) is a proinvasive and immunosuppressive cytokine that plays a major role in the malignant phenotype of gliomas. One…”
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Specific Spatial Learning Deficits Become Severe with Age in β-Amyloid Precursor Protein Transgenic Mice That Harbor Diffuse β-Amyloid Deposits but Do Not Form Plaques by Koistinaho, Milla, Ort, Michael, Cimadevilla, Jose M., Vondrous, Roman, Cordell, Barbara, Koistinaho, Jari, Bures, Jan, Higgins, Linda S.

“…Memory impairment progressing to dementia is the main clinical symptom of Alzheimer's disease (AD). AD is characterized histologically by the presence of…”
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Antitumor Activity of TGF-β Inhibitor is Dependent on the Microenvironment by MEDICHERLA, Satyanarayana, LINGYUN LI, WONG, Darren H, HIGGINS, Linda S, JING YING MA, KAPOUN, Ann M, GASPAR, Nicholas J, LIU, Yu-Wang, MANGADU, Ruban, O'YOUNG, Gilbert, PROTTER, Andrew A, SCHREINER, George F

“…Pancreatic cancer is one of the deadliest forms of cancer and effective treatment remains a clinical challenge. Transforming growth factor-beta (TGF-beta) has…”
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Inhibition of p38α mitogen-activated protein kinase prevents the development of osteolytic bone disease, reduces tumor burden, and increases survival in murine models of multiple myeloma by VANDERKERKEN, Karin, MEDICHERLA, Satya, CROUCHER, Peter I, COULTON, Les, DE RAEVE, Hendrik, WILLEMS, Angelo, LAWSON, Michelle, VAN CAMP, Ben, PROTTER, Andrew A, HIGGINS, Linda S, MENU, Eline

“…Abstract The bone microenvironment plays a critical role in supporting the growth and survival of multiple myeloma as well as in the development of osteolytic…”
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