Search Results - "Higgins, Linda"

Selective peroxisome proliferator-activated receptor γ (PPARγ) modulation as a strategy for safer therapeutic PPARγ activation by Higgins, Linda Slanec, DePaoli, Alex M

“…Peroxisome proliferator-activated receptor γ (PPARγ) is a clinically validated target for treatment of insulin resistance. PPARγ activation by full agonists…”
Get full text

Unicompartmental Knee Arthroplasty with the Oxford Prosthesis in Patients with Medial Compartment Arthritis by Emerson, Roger H, Higgins, Linda L

“…BackgroundThe mobile-bearing feature of the Oxford unicompartmental knee replacement has the potential to optimize polyethylene wear, thereby leading to…”
Get full text

Can a selective PPARγ modulator improve glycemic control in patients with type 2 diabetes with fewer side effects compared with pioglitazone? by DePaoli, Alex M, Higgins, Linda S, Henry, Robert R, Mantzoros, Christos, Dunn, Fredrick L

“…INT131 besylate is a potent, nonthiazolidinedione, selective peroxisome proliferator-activated receptor γ (PPARγ) modulator (SPPARM) designed to improve…”
Get full text

Basic Mechanisms Responsible for Osteolytic and Osteoblastic Bone Metastases by GUISE, Theresa A, MOHAMMAD, Khalid S, CHIRGWIN, John M, CLINES, Gregory, STEBBINS, Elizabeth G, WONG, Darren H, HIGGINS, Linda S, VESSELLA, Robert, COREY, Eva, PADALECKI, Susan, SUVA, Larry

“…Certain solid tumors metastasize to bone and cause osteolysis and abnormal new bone formation. The respective phenotypes of dysregulated bone destruction and…”
Get full text

Editorial Expression of Concern: p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells by Hideshima, Teru, Podar, Klaus, Chauhan, Dharminder, Ishitsuka, Kenji, Mitsiades, Constantine, Tai, Yu-Tzu, Hamasaki, Makoto, Raje, Noopur, Hideshima, Hiromasa, Schreiner, George, Nguyen, Aaron N., Navas, Tony, Munshi, Nikhil C., Richardson, Paul G., Higgins, Linda S., Anderson, Kenneth C.

Get full text

Selective modulation of PPARγ activity can lower plasma glucose without typical thiazolidinedione side-effects in patients with Type 2 diabetes by Dunn, Fredrick L, Higgins, Linda S, Fredrickson, Jill, DePaoli, Alex M

“…Abstract Objective INT131 besylate is a potent non-thiazolidinedione selective peroxisome proliferator-activated receptor γ (PPARγ)  modulator (SPPARM)…”
Get full text

Mitogen-activated protein kinase phosphatase-1 is a mediator of breast cancer chemoresistance by SMALL, George W, SHI, Yue Y, HIGGINS, Linda S, ORLOWSKIL, Robert Z

“…The mitogen-activated protein kinase (MAPK) phosphatase (MKP)-1 is overexpressed in a large proportion of breast cancers, and in some systems interferes with…”
Get full text

Inhibition of the TGF-β receptor I kinase promotes hematopoiesis in MDS by Zhou, Li, Nguyen, Aaron N., Sohal, Davendra, Ying Ma, Jing, Pahanish, Perry, Gundabolu, Krishna, Hayman, Josh, Chubak, Adam, Mo, Yongkai, Bhagat, Tushar D., Das, Bhaskar, Kapoun, Ann M., Navas, Tony A., Parmar, Simrit, Kambhampati, Suman, Pellagatti, Andrea, Braunchweig, Ira, Zhang, Ying, Wickrema, Amittha, Medicherla, Satyanarayana, Boultwood, Jacqueline, Platanias, Leonidas C., Higgins, Linda S., List, Alan F., Bitzer, Markus, Verma, Amit

“…MDS is characterized by ineffective hematopoiesis that leads to peripheral cytopenias. Development of effective treatments has been impeded by limited insight…”
Get full text

SD-208, a novel transforming growth factor β receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo by UHL, Martin, AULWURM, Steffen, MURPHY, Alison, WONG, Darren H, WICK, Wolfgang, HIGGINS, Linda S, WELLER, Michael, WISCHHUSEN, Jörg, WEILER, Markus, JING YING MA, ALMIREZ, Ramona, MANGADU, Ruban, LIU, Yu-Wang, PLATTEN, Michael, HERRLINGER, Ulrich

“…The cytokine transforming growth factor (TGF)-beta, by virtue of its immunosuppressive and promigratory properties, has become a major target for the…”
Get full text

Progressive transforming growth factor β1-induced lung fibrosis is blocked by an orally active alk5 kinase inhibitor by BONNIAUD, Philippe, MARGETTS, Peter J, PROTTER, Andrew A, GAULDIE, Jack, KOLB, Martin, SCHROEDER, Jane Ann, KAPOUN, Ann M, DAMM, Debby, MURPHY, Alison, CHAKRAVARTY, Sarvajit, DUGAR, Sundeep, HIGGINS, Linda

Get full text

Hospital Nurses' Work Activity in a Technology-Rich Environment: A Triangulated Quality Improvement Assessment by Higgins, Linda W, Shovel, Judith A, Bilderback, Andrew L, Lorenz, Holly L, Martin, Susan C, Rogers, Debra J, Minnier, Tamra E

“…The aim of this project was to describe hospital nurses' work activity through observations, nurses' perceptions of time spent on tasks, and electronic health…”
Get full text

Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors by Navas, Tony A., Mohindru, Mani, Estes, Myka, Ma, Jing Ying, Sokol, Lubomir, Pahanish, Perry, Parmar, Simrit, Haghnazari, Edwin, Zhou, Li, Collins, Robert, Kerr, Irene, Nguyen, Aaron N., Xu, Yin, Platanias, Leonidas C., List, Alan A., Higgins, Linda S., Verma, Amit

“…The myelodysplastic syndromes (MDSs) are collections of heterogeneous hematologic diseases characterized by refractory cytopenias as a result of ineffective…”
Get full text

Parent and Child Perceptions of a Self-Regulated, Home-Based Exercise Program for Children With Cystic Fibrosis by Happ, Mary Beth, Hoffman, Leslie A., DiVirgilio, Dana, Higgins, Linda W., Orenstein, David M.

“…BACKGROUND:Despite recognized benefits, many children with cystic fibrosis (CF) do not consistently participate in physical activities. There is little…”
Get full text

Inhibition of transforming growth factor beta signaling reduces pancreatic adenocarcinoma growth and invasiveness by Gaspar, Nicholas J, Li, Lingyun, Kapoun, Ann M, Medicherla, Satyanarayana, Reddy, Mamatha, Li, Georgia, O'Young, Gilbert, Quon, Diana, Henson, Margaret, Damm, Deborah L, Muiru, Gladys T, Murphy, Alison, Higgins, Linda S, Chakravarty, Sarvajit, Wong, Darren H

“…Transforming growth factor beta (TGFbeta) is a pleiotropic factor that regulates cell proliferation, angiogenesis, metastasis, and immune suppression…”
Get more information

Comparison of a static with a mobile spacer in total knee infection by Emerson, Jr, Roger H, Muncie, Michael, Tarbox, Tiffera R, Higgins, Linda L

“…Patients with infections of a total knee arthroplasty were stratified by medical status. Twenty-six knees in 26 patients treated with a static…”
Get more information

How Successful Are Residents and Fellows at Quality Improvement? by Eden, Elizabeth L., Harrington, Terence, Chen, Ling-Wan, Chelluri, Lakshmipathi, Higgins, Linda W., Freel, Jennifer A., DeKosky, Allison, Bump, Gregory M.

“…Nationally, there is an expectation that residents and fellows participate in quality improvement (QI), preferably interprofessionally. Hospitals and educators…”
Get full text

Role of the p38 mitogen-activated protein kinase pathway in the generation of arsenic trioxide-dependent cellular responses by Giafis, Nick, Katsoulidis, Efstratios, Sassano, Antonella, Tallman, Martin S, Higgins, Linda S, Nebreda, Angel R, Davis, Roger J, Platanias, Leonidas C

“…Arsenic trioxide (As(2)O(3)) induces differentiation and apoptosis of leukemic cells in vitro and in vivo, but the precise mechanisms that mediate such effects…”
Get full text

The Development of INT131 as a Selective PPAR Modulator: Approach to a Safer Insulin Sensitizer by Higgins, Linda S., Mantzoros, Christos S.

“…INT131 (formerly T0903131, T131, AMG131) is a potent non-thiazolidinedione (TZD) selective peroxisome proliferator-activated receptor modulator (SPPARM)…”
Get full text

p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells by HIDESHIMA, Teru, PODAR, Klaus, NGUYEN, Aaron N, NAVAS, Tony, MUNSHI, Nikhil C, RICHARDSON, Paul G, HIGGINS, Linda S, ANDERSON, Kenneth C, CHAUHAN, Dharminder, ISHITSUKA, Kenji, MITSIADES, Constantine, TAI, Yu-Tzu, HAMASAKI, Makoto, RAJE, Noopur, HIDESHIMA, Hiromasa, SCHREINER, George

“…Although PS-341 (bortezomib) is a promising agent to improve multiple myeloma (MM) patient outcome, 65% of patients with relapsed and refractory disease do not…”
Get full text

Comparison of a mobile with a fixed-bearing unicompartmental knee implant by Emerson, Jr, Roger H, Hansborough, Thomas, Reitman, Richard D, Rosenfeldt, Wolfgang, Higgins, Linda L

“…Two well-matched groups of patients with unicompartmental knee arthroplasties were compared. The first 51 knees were treated with a fixed-bearing knee implant…”
Get more information