Search Results - "Higgins, LS"

Tuberculosis and Porphyria by HIGGINS, L. S

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SD-208, a novel transforming growth factor β receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo by UHL, Martin, AULWURM, Steffen, MURPHY, Alison, WONG, Darren H, WICK, Wolfgang, HIGGINS, Linda S, WELLER, Michael, WISCHHUSEN, Jörg, WEILER, Markus, JING YING MA, ALMIREZ, Ramona, MANGADU, Ruban, LIU, Yu-Wang, PLATTEN, Michael, HERRLINGER, Ulrich

“…The cytokine transforming growth factor (TGF)-beta, by virtue of its immunosuppressive and promigratory properties, has become a major target for the…”
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Specific Spatial Learning Deficits Become Severe with Age in β-Amyloid Precursor Protein Transgenic Mice That Harbor Diffuse β-Amyloid Deposits but Do Not Form Plaques by Koistinaho, Milla, Ort, Michael, Cimadevilla, Jose M., Vondrous, Roman, Cordell, Barbara, Koistinaho, Jari, Bures, Jan, Higgins, Linda S.

“…Memory impairment progressing to dementia is the main clinical symptom of Alzheimer's disease (AD). AD is characterized histologically by the presence of…”
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p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells by HIDESHIMA, Teru, PODAR, Klaus, NGUYEN, Aaron N, NAVAS, Tony, MUNSHI, Nikhil C, RICHARDSON, Paul G, HIGGINS, Linda S, ANDERSON, Kenneth C, CHAUHAN, Dharminder, ISHITSUKA, Kenji, MITSIADES, Constantine, TAI, Yu-Tzu, HAMASAKI, Makoto, RAJE, Noopur, HIDESHIMA, Hiromasa, SCHREINER, George

“…Although PS-341 (bortezomib) is a promising agent to improve multiple myeloma (MM) patient outcome, 65% of patients with relapsed and refractory disease do not…”
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Transforming Growth Factor β Receptor I Kinase Inhibitor Down-Regulates Cytokine Secretion and Multiple Myeloma Cell Growth in the Bone Marrow Microenvironment by HAYASHI, Toshiaki, HIDESHIMA, Teru, MURPHY, Alison, CHAUHAN, Dharminder, HIGGINS, Linda S, ANDERSON, Kenneth C, NGUYEN, Aaron N, MUNOZ, Olivier, PODAR, Klaus, HAMASAKI, Makoto, ISHITSUKA, Kenji, YASUI, Hiroshi, RICHARDSON, Paul, CHAKRAVARTY, Sarvajit

“…Purpose: Transforming growth factors (TGFs) have pleiotropic biological effects on tumor cells and their environment. In multiple myeloma (MM), we have…”
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β-Amyloid Precursor Protein Transgenic Mice That Harbor Diffuse Aβ Deposits but Do Not Form Plaques Show Increased Ischemic Vulnerability: Role of Inflammation by Koistinaho, Milla, Kettunen, Mikko I., Goldsteins, Gundars, Keinänen, Riitta, Salminen, Antero, Ort, Michael, Bures, Jan, Liu, David, Kauppinen, Risto A., Higgins, Linda S., Koistinaho, Jari

“…β-amyloid (Aβ), derived form the β-amyloid precursor protein (APP), is important for the pathogenesis of Alzheimer's disease (AD), which is characterized by…”
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Insecticidal proteins from Bacillus thuringiensis protect corn from corn rootworms by Moellenbeck, Daniel J, Peters, Melvin L, Bing, James W, Rouse, James R, Higgins, Laura S, Sims, Lynne, Nevshemal, Tony, Marshall, Lisa, Ellis, R. Tracy, Bystrak, Paul G, Lang, Bruce A, Stewart, James L, Kouba, Kristen, Sondag, Valerie, Gustafson, Vicki, Nour, Katy, Xu, Deping, Swenson, Jan, Zhang, Jian, Czapla, Thomas, Schwab, George, Jayne, Susan, Stockhoff, Brian A, Narva, Kenneth, Schnepf, H. Ernest, Stelman, Steven J, Poutre, Candace, Koziel, Michael, Duck, Nicholas

“…Field tests of corn co-expressing two new delta-endotoxins from Bacillus thuringiensis (Bt) have demonstrated protection from root damage by western corn…”
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The nicking endonuclease N.BstNBI is closely related to type IIs restriction endonucleases MlyI and PleI by Higgins, L S, Besnier, C, Kong, H

“…N.BstNBI is a nicking endonuclease that recognizes the sequence GAGTC and nicks the top strand preferentially. The Type IIs restriction endonucleases PleI and…”
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Age-Related Learning Deficits in Transgenic Mice Expressing the 751-Amino Acid Isoform of Human β-Amyloid Precursor Protein by Moran, Paula M., Higgins, Linda S., Cordell, Barbara, Moser, Paul C.

“…The β-amyloid precursor protein (β-APP), from which the β-A4 peptide is derived, is considered to be central to the pathogenesis of Alzheimer disease (AD)…”
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Early Alzheimer disease-like histopathology increases in frequency with age in mice transgenic for beta-APP751 by Higgins, L S, Rodems, J M, Catalano, R, Quon, D, Cordell, B

“…beta-Amyloid deposition and neurofibrillary tangle formation are two histopathological features of Alzheimer disease. We have previously reported that…”
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Transgenic mouse brain histopathology resembles early Alzheimer's disease by Higgins, L S, Holtzman, D M, Rabin, J, Mobley, W C, Cordell, B

“…Transgenic mice expressing the 751-amino acid form of the human amyloid precursor protein develop extracellular beta-amyloid protein (A beta)-immunoreactive…”
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Expression of human apolipoprotein E downregulates amyloid precursor protein-induced ischemic susceptibility by KOISTINAHO, Milla, KETTUNEN, Mikko I, HOLTZMAN, David M, KAUPPINEN, Risto A, HIGGINS, Linda S, KOISTINAHO, Jari

“…Epidemiological findings and experimental data on transgenic mice show that Alzheimer's disease-related changes render the brain more susceptible to ischemic…”
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P3 beta-amyloid peptide has a unique and potentially pathogenic immunohistochemical profile in Alzheimer's disease brain by Higgins, LS, Murphy, GM, Jr, Forno, LS, Catalano, R, Cordell, B

“…The presence of beta-amyloid in brain tissue is characteristic of Alzheimer's disease (AD). A naturally occurring derivative of the beta-amyloid peptide, p3,…”
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Transgenic mice expressing human beta-APP751, but not mice expressing beta-APP695, display early Alzheimer's disease-like histopathology by Higgins, L S, Catalano, R, Quon, D, Cordell, B

“…Mice transgenic for the 751 amino acid isoform of the human beta-amyloid precursor protein (beta-APP) driven by the rat neuron specific enolase (NSE) promoter…”
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Oviposition by European corn borer (Lepidoptera: Crambidae) in response to various transgenic corn events by Hellmich, R.L, Higgins, L.S, Witkowski, J.F, Campbell, J.E, Lewis, L.C

“…Oviposition preference by European corn borers, Ostrinia nubilalis (Hubner), for or against transgenic corn would influence amounts of refuge required for…”
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Genetically Engineered Animal Models of Alzheimer's Disease by Higgins, Linda S., Cordell, Barbara

“…The application of transgenic research has proven to be a powerful and popular tool for investigating the contribution of specific genes known or suspected to…”
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Striving for useful phenotypes in β-APP transgenic mice by Higgins, Linda S., Cordell, Barbara

“…The goal of developing a manipulable animal model displaying features relevant to Alzheimer's disease (AD) has been an elusive one but one toward which…”
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Transgenic mice and modeling Alzheimer's disease by Higgins, L S, Cordell, B

“…The etiology of Alzheimer's disease (AD) is poorly understood, and no effective therapies are available. Although histopathology of the disease has been…”
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Increased amyloid production from aberrant beta-amyloid precursor proteins by ZIYANG ZHONG, QUON, D, HIGGINS, L. S, HIGAKI, J, CORDELL, B

“…The 4-kDa beta-amyloid protein that forms fibrillar deposits in Alzheimer's diseased brains is derived from a large precursor, the beta-amyloid precursor…”
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Immunological identification of a nicotinic acetylcholine receptor on bovine chromaffin cells by Higgins, LS, Berg, DK

“…Two probes previously shown to distinguish the nicotinic ACh receptor of chick ciliary ganglion neurons also recognize a component on the surface of bovine…”
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