Search Results - "Higgins, Ixavier A."

Translating Lupus: Comparative Transcriptional Profiles of Preclinical Lupus Models and Their Relevance to Human Disease by Parker, James T, Chang, Ching-Yun, Kersjes, Kara, Higgins, Ixavier A, Vendel, Andrew C, Chang, William Y

“…Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease which can present with mixed organ involvement. Kidney involvement in lupus…”
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Combining tau-PET and fMRI meta-analyses for patient-centered prediction of cognitive decline in Alzheimer's disease by Biel, Davina, Luan, Ying, Brendel, Matthias, Hager, Paul, Dewenter, Anna, Moscoso, Alexis, Otero Svaldi, Diana, Higgins, Ixavier A, Pontecorvo, Michael, Römer, Sebastian, Steward, Anna, Rubinski, Anna, Zheng, Lukai, Schöll, Michael, Shcherbinin, Sergey, Ewers, Michael, Franzmeier, Nicolai

“…Tau-PET is a prognostic marker for cognitive decline in Alzheimer's disease, and the heterogeneity of tau-PET patterns matches cognitive symptom heterogeneity…”
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Tau as a diagnostic instrument in clinical trials to predict amyloid in Alzheimer's disease by Shcherbinin, Sergey, Morris, Amanda, Higgins, Ixavier A, Tunali, Ilke, Lu, Ming, Deveau, Carmen, Southekal, Sudeepti, Kotari, Vikas, Evans, Cynthia D, Arora, Anupa K, Collins, Emily C, Pontecorvo, Michael, Mintun, Mark A, Sims, John R

“…Alzheimer's disease (AD) is characterized by the presence of both amyloid and tau pathology. In vivo diagnosis can be made with amyloid and tau positron…”
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Integrative Bayesian analysis of brain functional networks incorporating anatomical knowledge by Higgins, Ixavier A., Kundu, Suprateek, Guo, Ying

“…Recently, there has been increased interest in fusing multimodal imaging to better understand brain organization by integrating information on both brain…”
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Magnetic resonance imaging measures of brain volumes across the EXPEDITION trials in mild and moderate Alzheimer's disease dementia by Svaldi, Diana Otero, Higgins, Ixavier A., Holdridge, Karen C., Yaari, Roy, Case, Michael, Bracoud, Luc, Scott, David, Shcherbinin, Sergey, Sims, John R.

“…Introduction Solanezumab is a monoclonal antibody that preferentially binds soluble amyloid beta and promotes its clearance from the brain. The aim of this…”
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A difference degree test for comparing brain networks by Higgins, Ixavier A., Kundu, Suprateek, Choi, Ki Sueng, Mayberg, Helen S., Guo, Ying

“…Recently, there has been a proliferation of methods investigating functional connectivity as a biomarker for mental disorders. Typical approaches include…”
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Assessment of Efficacy and Safety of Zagotenemab: Results From PERISCOPE-ALZ, a Phase 2 Study in Early Symptomatic Alzheimer Disease by Fleisher, Adam S, Munsie, Leanne M, Perahia, David G S, Andersen, Scott W, Higgins, Ixavier A, Hauck, Paula M, Lo, Albert C, Sims, John R, Brys, Miroslaw, Mintun, Mark

“…Zagotenemab (LY3303560), a monoclonal antibody that preferentially targets misfolded, extracellular, aggregated tau, was assessed in the PERISCOPE-ALZ phase 2…”
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Distinct associations between tau PET and cognitive impairment across brain regions and cognitive domains in Alzheimer’s disease by Rathore, Saima, Tronchin, Giulia, Higgins, Ixavier A., Wessels, Alette M, Iaccarino, Leonardo, Sims, John R., Mintun, Mark A., Shcherbinin, Sergey

“…Background Compared with biofluid‐biomarkers, tau‐PET shows stronger association with cognitive impairment (Ossenkoppele,R‐2021) and decline, and better…”
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APOEε4 facilitates the accumulation and connectivity‐mediated spreading of tau pathology at lower amyloid levels by Steward, Anna, Biel, Davina, Dewenter, Anna, Roemer, Sebastian Niclas, Wanger, Fabian, Dehsarvi, Amir, Svaldi, Diana, Higgins, Ixavier A., Brendel, Matthias, Shcherbinin, Sergey, Ewers, Michael, Franzmeier, Nicolai

“…Background Targeting amyloid (Aß) may show highest clinical efficacy when preventing downstream tau spreading and subsequent neurodegeneration. Thus, it’s…”
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APOEε4 facilitates the accumulation and connectivity‐mediated spreading of tau pathology at lower amyloid levels by Steward, Anna, Biel, Davina, Dewenter, Anna, Roemer, Sebastian Niclas, Wanger, Fabian, Dehsarvi, Amir, Svaldi, Diana, Higgins, Ixavier A., Brendel, Matthias, Shcherbinin, Sergey, Ewers, Michael, Franzmeier, Nicolai

“…Background Targeting amyloid (Aß) may show highest clinical efficacy when preventing downstream tau spreading and subsequent neurodegeneration. Thus, it’s…”
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Longitudinal flortaucipir accumulation is spatially distinct across baseline tau burden stages: Summary from three phase 2/3 interventional trials in Alzheimer’s disease by Shcherbinin, Sergey, Higgins, Ixavier A., Lu, Ming, Pontecorvo, Michael J., Lo, Albert C., Sims, John R.

“…Background To date, regional patterns of the longitudinal tau accumulation in Alzheimer’s Disease (AD) have been examined in very few studies with limited…”
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Longitudinal flortaucipir accumulation is spatially distinct across baseline tau burden stages: Summary from three phase 2/3 interventional trials in Alzheimer’s disease: Neuroimaging: Understanding tau progression by Shcherbinin, Sergey, Higgins, Ixavier A., Lu, Ming, Pontecorvo, Michael J., Lo, Albert C., Sims, John R.

“…Abstract Background To date, regional patterns of the longitudinal tau accumulation in Alzheimer’s Disease (AD) have been examined in very few studies with…”
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Predicting regional tau accumulation with machine learning‐based tau‐PET and advanced radiomics by Rathore, Saima, Higgins, Ixavier A., Wang, Jian, Kennedy, Ian A., Iaccarino, Leonardo, Burnham, Samantha C., Pontecorvo, Michael J., Shcherbinin, Sergey

“…Abstract INTRODUCTION Alzheimer's disease is partially characterized by the progressive accumulation of aggregated tau‐containing neurofibrillary tangles…”
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Network diffusion model enhances predictions of future tau‐PET burden in Alzheimer’s patients: Development of new models and analysis methods: Novel imaging analysis by Damasceno, Pablo F., La Joie, Renaud, Shcherbinin, Sergey, Southekal, Sudeepti, Kotari, Vikas, Higgins, Ixavier A., Collins, Emily C., Rabinovici, Gil D., Mintun, Mark A., Raj, Ashish

“…Abstract Background Precisely measuring longitudinal tau PET is important for clinical trial design. Here we use a group of patients diagnosed with AD dementia…”
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Network diffusion model enhances predictions of future tau‐PET burden in Alzheimer’s patients by Damasceno, Pablo F., La Joie, Renaud, Shcherbinin, Sergey, Southekal, Sudeepti, Kotari, Vikas, Higgins, Ixavier A., Collins, Emily C., Rabinovici, Gil D., Mintun, Mark A., Raj, Ashish

“…Background Precisely measuring longitudinal tau PET is important for clinical trial design. Here we use a group of patients diagnosed with AD dementia (N = 28)…”
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[11C]PiB and [18F]AV45 PET radiotracers show different rates of amyloid‐β clearance by Chen, Charles D., McCullough, Austin A., Gordon, Brian A., Joseph‐Mathurin, Nelly, Wang, Guoqiao, Li, Yan, Xiong, Chengjie, Pontecorvo, Michael J., Klein, Gregory, Shcherbinin, Sergey, Higgins, Ixavier A., Masters, Colin L, Clifford, David B., van Dyck, Christopher H, Masellis, Mario, Hsiung, Ging‐Yuek Robin, Gauthier, Serge, Bateman, Randall J., McDade, Eric, Salloway, Stephen P., Benzinger, Tammie L.S.

“…Background Results from the first Dominantly Inherited Alzheimer Network Trials Unit (DIAN‐TU) clinical trial showed Gantenerumab reduces amyloid‐β deposition…”
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Statistical Methods for Estimating and Analyzing Brain Functional Connectivity by Higgins, Ixavier A

“…In recent years, network science has become an increasingly popular approach for investigating interdependencies between spatially distinct brain regions. The…”
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Integrative Bayesian Analysis of Brain Functional Networks Incorporating Anatomical Knowledge by Higgins, Ixavier A, Kundu, Suprateek, Guo, Ying

“…Recently, there has been increased interest in fusing multimodal imaging to better understand brain organization. Specifically, accounting for knowledge of…”
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A Differential Degree Test for Comparing Brain Networks by Higgins, Ixavier A, Guo, Ying, Kundu, Suprateek, Choi, Ki Sueng, Mayberg, Helen

“…Recently, graph theory has become a popular method for characterizing brain functional organization. One important goal in graph theoretical analysis of brain…”
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