Search Results - "Higgins, Dominique M"

Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism by Upadhyayula, Pavan S., Higgins, Dominique M., Mela, Angeliki, Banu, Matei, Dovas, Athanassios, Zandkarimi, Fereshteh, Patel, Purvi, Mahajan, Aayushi, Humala, Nelson, Nguyen, Trang T. T., Chaudhary, Kunal R., Liao, Lillian, Argenziano, Michael, Sudhakar, Tejaswi, Sperring, Colin P., Shapiro, Benjamin L., Ahmed, Eman R., Kinslow, Connor, Ye, Ling F., Siegelin, Markus D., Cheng, Simon, Soni, Rajesh, Bruce, Jeffrey N., Stockwell, Brent R., Canoll, Peter

“…Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated fatty acyl moieties. Glutathione, the key cellular antioxidant…”
Get full text

Semaphorin 3A mediated brain tumor stem cell proliferation and invasion in EGFRviii mutant gliomas by Higgins, Dominique M O, Caliva, Maisel, Schroeder, Mark, Carlson, Brett, Upadhyayula, Pavan S, Milligan, Brian D, Cheshier, Samuel H, Weissman, Irving L, Sarkaria, Jann N, Meyer, Fredric B, Henley, John R

“…Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults, with a median survival of approximately 15 months. Semaphorin 3A (Sema3A),…”
Get full text

Oncolytic Virotherapy for High-Grade Glioma and Current Evidence and Factors to Consider for Incorporation into Clinical Practice by Soldozy, Sauson, Eichberg, Daniel G, Morell, Alexis A, Luther, Evan, Lu, Victor M, Higgins, Dominique M O, Patel, Nitesh V, Shah, Ashish H, Hanft, Simon J, Komotar, Ricardo J, Ivan, Michael E

“…Brain tumor incidence is on the rise, and glioblastoma comprises the majority of primary tumors. Despite maximal safe resection and adjuvant chemoradiation,…”
Get full text

Magnetic resonance imaging-graded hypothalamic compression in surgically treated adult craniopharyngiomas determining postoperative obesity by Van Gompel, Jamie J, Nippoldt, Todd B, Higgins, Dominique M, Meyer, Fredric B

“…Obesity as a consequence of management of pediatric craniopharyngioma is a well-described phenomenon related to the degree of hypothalamic involvement…”
Get full text

Symptomatic Rathke cleft cysts: extent of resection and surgical complications by Higgins, Dominique M, Van Gompel, Jamie J, Nippoldt, Todd B, Meyer, Fredric B

“…Rathke cleft cysts (RCCs) are benign masses arising from the embryological Rathke pouch, and are commonly treated by transsphenoidal surgery. The authors…”
Get full text

A multicenter analysis of the prognostic value of histone H3 K27M mutation in adult high-grade spinal glioma by Akinduro, Oluwaseun O, Garcia, Diogo P, Higgins, Dominique M O, Vivas-Buitrago, Tito, Jentoft, Mark, Solomon, David A, Daniels, David J, Pennington, Zach, Sherman, Wendy J, Delgardo, Mychael, Bydon, Mohamad, Kalani, Maziyar A, Zanazzi, George, Tsankova, Nadejda, Bendok, Bernard R, McCormick, Paul C, Sciubba, Daniel M, Lo, Sheng-Fu Larry, Clarke, Jennifer L, Abode-Iyamah, Kingsley, Quiñones-Hinojosa, Alfredo

“…High-grade spinal glioma (HGSG) is a rare but aggressive tumor that occurs in both adults and children. Histone H3 K27M mutation correlates with poor prognosis…”
Get full text

Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers by Ye, Ling F, Chaudhary, Kunal R, Zandkarimi, Fereshteh, Harken, Andrew D, Kinslow, Connor J, Upadhyayula, Pavan S, Dovas, Athanassios, Higgins, Dominique M, Tan, Hui, Zhang, Yan, Buonanno, Manuela, Wang, Tony J. C, Hei, Tom K, Bruce, Jeffrey N, Canoll, Peter D, Cheng, Simon K, Stockwell, Brent R

“…Although radiation is widely used to treat cancers, resistance mechanisms often develop and involve activation of DNA repair and inhibition of apoptosis…”
Get full text

Nitric oxide synthase inhibitors as potential therapeutic agents for gliomas: A systematic review by Merenzon, Martin A., Hincapie Arias, Elsa, Bhatia, Shovan, Shah, Ashish H., Higgins, Dominique M.O., Villaverde, Marcela, Belgorosky, Denise, Eijan, Ana M.

“…Gliomas represent the most prevalent form of brain tumors, among which glioblastomas are the most malignant subtype. Despite advances in comprehending their…”
Get full text

Commentary: Malignant Pineal Parenchymal Tumors in Adults: A National Cancer Database Analysis by Prem Kumar, Rohit, Patel, Nitesh V, Higgins, Dominique M O, Kader, Michael, Komotar, Ricardo J, Ivan, Michael E

Get full text

Association between tumor location and toxicity outcomes after stereotactic radiosurgery for brain metastases by Wang, Boya, Bukowski, Alexandra, Kaidar-Person, Orit, Choi, James M., Sasaki-Adams, Deanna M., Jaikumar, Sivakumar, Higgins, Dominique M., Ewend, Matthew G., Sengupta, Soma, Zagar, Timothy M., Yanagihara, Theodore K., Tepper, Joel E., Marks, Lawrence B., Shen, Colette J.

“…Toxicities associated with stereotactic radiosurgery (SRS) are important when considering treatment and supportive management for patients with brain…”
Get full text

The Sledgehammer in Precision Medicine: Dexamethasone and Immunotherapeutic Treatment of Glioma by Upadhyayula, Pavan S., Higgins, Dominique M., Argenziano, Michael G., Spinazzi, Eleonora F., Wu, Cheng-Chia, Canoll, Peter, Bruce, Jeffrey N.

“…Understanding dexamethasone's effect on the immune microenvironment in glioma patients is of key importance. We performed a comprehensive literature review…”
Get full text

Understanding the Impact of Obesity on Short-term Outcomes and In-hospital Costs After Instrumented Spinal Fusion by Higgins, Dominique M., Mallory, Grant W., Planchard, Ryan F., Puffer, Ross C., Ali, Mohamed, Gates, Marcus J., Clifton, William E., Jacob, Jeffrey T., Curry, Timothy B., Kor, Daryl J., Fogelson, Jeremy L., Krauss, William E., Clarke, Michelle J.

“…Abstract BACKGROUND: Obesity rates continue to rise along with the number of obese patients undergoing elective spinal fusion. OBJECTIVE: To evaluate the…”
Get full text

Preoperative Embolization of the External Carotid Artery Branches as an Adjunct to Superficial Temporal Artery–to–Middle Cerebral Artery Bypass by Van Gompel, Jamie J., MD, Higgins, Dominique M., MS, Chen, Selby G., MD, Bower, Regina S., MD, Meyer, Fredric B., MD

“…When technically feasible, the preferred revascularization procedure in patients with adult moyamoya disease is a superficial temporal artery–to–middle…”
Get full text

Using machine learning to evaluate large-scale brain networks in patients with brain tumors: Traditional and non-traditional eloquent areas by Morell, Alexis A, Eichberg, Daniel G, Shah, Ashish H, Luther, Evan, Lu, Victor M, Kader, Michael, Higgins, Dominique M O, Merenzon, Martin, Patel, Nitesh V, Komotar, Ricardo J, Ivan, Michael E

“…Abstract Background Large-scale brain networks and higher cognitive functions are frequently altered in neuro-oncology patients, but comprehensive non-invasive…”
Get full text

A cell state-specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma by Banu, Matei A, Dovas, Athanassios, Argenziano, Michael G, Zhao, Wenting, Sperring, Colin P, Cuervo Grajal, Henar, Liu, Zhouzerui, Higgins, Dominique MO, Amini, Misha, Pereira, Brianna, Ye, Ling F, Mahajan, Aayushi, Humala, Nelson, Furnari, Julia L, Upadhyayula, Pavan S, Zandkarimi, Fereshteh, Nguyen, Trang TT, Teasley, Damian, Wu, Peter B, Hai, Li, Karan, Charles, Dowdy, Tyrone, Razavilar, Aida, Siegelin, Markus D, Kitajewski, Jan, Larion, Mioara, Bruce, Jeffrey N, Stockwell, Brent R, Sims, Peter A, Canoll, Peter

“…Glioma cells hijack developmental programs to control cell state. Here, we uncover a glioma cell state-specific metabolic liability that can be therapeutically…”
Get full text

Commentary: Dejerine Syndrome Variant Due to Medullary Perforating Artery Ischemia During Foramen Magnum Meningioma Resection: 2-Dimensional Operative Video by Danish, Burhanuddin, Costello, Meredith C, Patel, Nitesh V, Higgins, Dominique M O, Komotar, Ricardo J, Ivan, Michael E

Get full text

Commentary: Endoscopic Endonasal Eustachian Tube Obliteration for Cerebrospinal Fluid Rhinorrhea: Case Series and Scoping Review by Berke, Chandler N., Patel, Nitesh V., Higgins, Dominique M. O., Kader, Michael, Komotar, Ricardo J., Ivan, Michael E.

Get full text

Safety of the utilization of telemedicine for brain tumor neurosurgery follow-up by Morell, Alexis A, Patel, Nitesh V, Eatz, Tiffany A, Levy, Adam S, Eichberg, Daniel G, Shah, Ashish H, Luther, Evan, Lu, Victor M, Kader, Michael, Higgins, Dominique M O, Ivan, Michael E, Komotar, Ricardo J

“…There is a need to evaluate the outcomes of patients who underwent brain tumor surgery with subsequent telemedicine or in-person follow-up during the COVID-19…”
Get full text

A cost-effective method for femoral head allograft procurement for spinal arthrodesis: an alternative to commercially available allograft by Brown, Desmond A, Mallory, Grant W, Higgins, Dominique M, Abdulaziz, Mohammed, Huddleston, Paul M, Nassr, Ahmad, Fogelson, Jeremy L, Clarke, Michelle J

“…A cost-effective procurement process for harvesting, storing, and using femoral head allografts is described. A brief review of the literature on the use of…”
Get full text

Right occipital transtentorial approach for a pineal malignant germ cell tumor by Gill, Brian J. A., Higgins, Dominique M., Banu, Matei A., Argenziano, Michael G., Feldstein, Neil A., Bruce, Jeffrey N.

“…Germ cell tumors account for up to 53% of the malignant lesions found in the pineal region and are typically managed with a combination of radiation therapy…”
Get full text