Search Results - "Higgins, Deborah L."

Telavancin, a Multifunctional Lipoglycopeptide, Disrupts both Cell Wall Synthesis and Cell Membrane Integrity in Methicillin-Resistant Staphylococcus aureus by HIGGINS, Deborah L, CHANG, Ray, QIUFENG GAO, CASS, Robert T, KARR, Dane E, BENTON, Bret M, HUMPHREY, Patrick P, DEBABOV, Dmitri V, LEUNG, Joey, WU, Terry, KRAUSE, Kevin M, SANDVIK, Erik, HUBBARD, Jeffrey M, KANIGA, Koné, SCHMIDT, Donald E

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In Vitro Activity of TD-6424 against Staphylococcus aureus by PACE, John L, KRAUSE, Kevin, KANIGA, Koné, JOHNSTON, Deborah, DEBABOV, Dmitri, WU, Terry, FARRINGTON, Lesley, LANE, Cassie, HIGGINS, Deborah L, CHRISTENSEN, Burt, JUDICE, J. Kevin

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The inability of tegaserod to affect platelet aggregation and coronary artery tone at supratherapeutic concentrations by Higgins, Deborah L., Ero, Mike P., Loeb, Michelle, Kersey, Kathryn, Hopkins, Alan, Beattie, David T.

“…In 2007, the results from a meta analysis of 29 clinical studies indicated that tegaserod (Zelnorm®), a 5-hydroxytryptamine 4 (5-HT 4 ) receptor agonist with…”
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Functional role of proteolytic cleavage at arginine-275 of human tissue plasminogen activator as assessed by site-directed mutagenesis by Tate, Keri M, Higgins, Deborah L, Holmes, William E, Winkler, Marjorie E, Heyneker, Herbert L, Vehar, Gordon A

“…Activation of the zymogen form of a serine protease is associated with a conformational change that follows proteolysis at a specific site. Tissue-type…”
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Multivalent Drug Design. Synthesis and In Vitro Analysis of an Array of Vancomycin Dimers by Griffin, John H, Linsell, Martin S, Nodwell, Matthew B, Chen, QiQi, Pace, John L, Quast, Kelly L, Krause, Kevin M, Farrington, Lesley, Wu, Terry X, Higgins, Deborah L, Jenkins, Thomas E, Christensen, Burton G, Judice, J. Kevin

“…The design, synthesis, and in vitro microbiological analysis of an array of forty covalently linked vancomycin dimers are reported. This work was undertaken to…”
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Interaction of one-chain and two-chain tissue plasminogen activator with intact and plasmin-degraded fibrin by Higgins, Deborah L, Vehar, Gordon A

“…Tissue-type plasminogen activator (t-PA) plays a central role in fibrinolysis in vivo. Although it is known to bind to fibrin, the dissociation constant (Kd)…”
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Plasminogen activator activities of equimolar complexes of streptokinase with variant recombinant plasminogens by Davidson, Donald J, Higgins, Deborah L, Castellino, Francis J

“…The steady-state kinetic characteristics of the amidolytic and plasminogen activator activities of equimolar streptokinase (SK)-human plasminogen (HPg) and…”
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Conformational similarities between one-chain and two-chain tissue plasminogen activator (t-PA): implications to the activation mechanism on one-chain t-PA by Nienaber, Vicki L, Young, Sharon L, Birktoft, Jens J, Higgins, Deborah L, Berliner, Lawrence J

“…Tissue plasminogen activator (t-PA) is an exceptional serine protease, because unlike most other serine protease zymogens single-chain tissue plasminogen…”
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A region of tissue plasminogen activator that affects plasminogen activation differentially with various fibrin(ogen)-related stimulators by Eastman, Donna, Wurm, Florian M, Van Reis, Robert, Higgins, Deborah L

“…The dissolution of blood clots by plasmin is normally initiated in vivo by the activation of plasminogen to plasmin through the activity of tissue plasminogen…”
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Protein affinity map of chemical space by Kauvar, Lawrence M, Villar, Hugo O, Sportsman, J.Richard, Higgins, Deborah L, Schmidt, Donald E

“…Affinity fingerprinting is a quantitative method for mapping chemical space based on binding preferences of compounds for a reference panel of proteins. An…”
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Glubodies: randomized libraries of glutathione transferase enzymes by Napolitano, Eugene W., Villar, Hugo O., Kauvar, Lawrence M., Higgins, Deborah L., Roberts, Doug, Mandac, Janis, Lee, Sandra K., Enggvist-Goldstein, A˚sa, Bukar, Robert, Calio, Brenda L., Ja¨ck, Hans Martin, Tainer, John A.

“…Background: The immunoglobulin framework has been mutagenized to engineer recombinant libraries of proteins as potential diagnostics and novel catalysts,…”
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Ligand-based protein alignment and isozyme specificity of glutathione S-transferase inhibitors by Koehler, Ryan T., Villar, Hugo O., Bauer, Karin E., Higgins, Deborah L.

“…Glutathione S‐transferases (GST, E.C.2.5.1.18) comprise a family of detoxification enzymes. Elevated levels of specific GST isozymes in tumor cells are thought…”
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Ligand-based protein alignment and isozyme specificity of glutathioneS-transferase inhibitors by Koehler, Ryan T., Villar, Hugo O., Bauer, Karin E., Higgins, Deborah L.

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Tissue plasminogen activator: the biochemistry and pharmacology of variants produced by mutagenesis by Higgins, D L, Bennett, W F

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Human fibrinogen by Shafer, J A, Higgins, D L

“…The structure and physical properties of human fibrinogen and fibrin are reviewed along with methods for the detection of products of their metabolism…”
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The incorporation of a fluorescent probe into the active sites of one- and two-chain tissue-type plasminogen activator by Higgins, D L, Lamb, M C

“…Dansyl-glutamyl-glycyl-arginyl chloromethyl ketone (DEGR-CK) was shown to inactivate both one- and two-chain human, recombinant tissue-type plasminogen…”
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The effect of the one-chain to two-chain conversion in tissue plasminogen activator: characterization of mutations at position 275 by Higgins, D L, Lamb, M C, Young, S L, Powers, D B, Anderson, S

“…Tissue plasminogen activator (t-PA) is homologous to other serine proteases and contains an apparent activation cleavage site at arginine 275. It has been…”
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Predicting ligand binding to proteins by affinity fingerprinting by Kauvar, Lawrence M., Higgins, Deborah L., Villar, Hugo O., Sportsman, J.Richard, Engqvist-Goldstein, Åsa, Bukar, Robert, Bauer, Karin E., Dilley, Hara, Rocke, David M.

“…Background: There are many ways to represent a molecule's properties, including atomic-connectivity drawings. NMR spectra, and molecular orbital models. Prior…”
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Fibrinogen Petoskey: identification of a new dysfibrinogenemia characterized by altered release of fibrinopeptide A by Higgins, D L, Penner, J A, Shafer, J A

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