Search Results - "Higgins, Claire A"

Generation of 3D skin equivalents fully reconstituted from human induced pluripotent stem cells (iPSCs) by Itoh, Munenari, Umegaki-Arao, Noriko, Guo, Zongyou, Liu, Liang, Higgins, Claire A, Christiano, Angela M

“…Recent generation of patient-specific induced pluripotent stem cells (PS-iPSCs) provides significant advantages for cell- and gene-based therapy. Establishment…”
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Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth by Higgins, Claire A., Chen, James C., Cerise, Jane E., Jahoda, Colin A. B., Christiano, Angela M.

“…De novo organ regeneration has been observed in several lower organisms, as well as rodents; however, demonstrating these regenerative properties in human…”
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Methods for the isolation and 3D culture of dermal papilla cells from human hair follicles by Topouzi, Helena, Logan, Niall J., Williams, Greg, Higgins, Claire A.

“…The dermal papilla is a cluster of mesenchymal cells located at the base of the hair follicle which have a number of important roles in the regulation of hair…”
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Melanin Transfer in Human 3D Skin Equivalents Generated Exclusively from Induced Pluripotent Stem Cells by Gledhill, Karl, Guo, Zongyou, Umegaki-Arao, Noriko, Higgins, Claire A, Itoh, Munenari, Christiano, Angela M

“…The current utility of 3D skin equivalents is limited by the fact that existing models fail to recapitulate the cellular complexity of human skin. They often…”
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FGF5 is a crucial regulator of hair length in humans by Higgins, Claire A., Petukhova, Lynn, Harel, Sivan, Ho, Yuan Y., Drill, Esther, Shapiro, Lawrence, Wajid, Muhammad, Christiano, Angela M.

“…Mechanisms that regulate the growth of eyelashes have remained obscure. We ascertained two families from Pakistan who presented with familial trichomegaly, or…”
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Male pattern hair loss: Can developmental origins explain the pattern? by Redmond, Leah C., Limbu, Summik, Farjo, Bessam, Messenger, Andrew G., Higgins, Claire A.

“…Male pattern hair loss (MPHL), also referred to as male androgenetic alopecia (AGA) is the most common type of non‐scarring progressive hair loss, with 80% of…”
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Pharmacologic inhibition of JAK-STAT signaling promotes hair growth by Harel, Sivan, Higgins, Claire A, Cerise, Jane E, Dai, Zhenpeng, Chen, James C, Clynes, Raphael, Christiano, Angela M

“…Several forms of hair loss in humans are characterized by the inability of hair follicles to enter the growth phase (anagen) of the hair cycle after being…”
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Lateral pressure equalisation as a principle for designing support surfaces to prevent deep tissue pressure ulcers by Boyle, Colin J, Carpanen, Diagarajen, Pandelani, Thanyani, Higgins, Claire A, Masen, Marc A, Masouros, Spyros D

“…When immobile or neuropathic patients are supported by beds or chairs, their soft tissues undergo deformations that can cause pressure ulcers. Current support…”
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Anagen hair follicles transplanted into mature human scars remodel fibrotic tissue by Plotczyk, Magdalena, Jiménez, Francisco, Limbu, Summik, Boyle, Colin J., Ovia, Jesse, Almquist, Benjamin D., Higgins, Claire A.

“…Despite the substantial impact of skin scarring on patients and the healthcare system, there is a lack of strategies to prevent scar formation, let alone…”
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Generation and characterization of multipotent stem cells from established dermal cultures by Hill, Rebecca P, Gledhill, Karl, Gardner, Aaron, Higgins, Claire A, Crawford, Heather, Lawrence, Clifford, Hutchison, Christopher J, Owens, William A, Kara, Bo, James, S Elizabeth, Jahoda, Colin A B

“…Human multipotent skin derived precursor cells (SKPs) are traditionally sourced from dissociated dermal tissues; therefore, donor availability may become…”
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A catena between psychiatric disorders and non‐scarring alopecias—A systematic review by Forneris Crego, Ana L., Therianou, Anastasia, Hashemi, Parastoo, Higgins, Claire A.

“…For many years, clinical observations have suggested that there is an intrinsic connection between psychological state and skin diseases. Stress responses are…”
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Regenerative medicine and hair loss: how hair follicle culture has advanced our understanding of treatment options for androgenetic alopecia by Higgins, Claire A, Christiano, Angela M

“…Many of the current drug therapies for androgenetic alopecia were discovered serendipitously, with hair growth observed as an off-target effect when drugs were…”
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Plantar Skin: A Callus Design? by Hayes, Jack, Higgins, Claire A

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Mast cells reside in myometrium and cervix, but are dispensable in mice for successful pregnancy and labor by Menzies, Fiona M, Higgins, Claire A, Shepherd, Malcolm C, Nibbs, Robert JB, Nelson, Scott M

“…Parturition is associated with myometrial and cervical inflammation. The causes and consequences of this inflammatory response are not clear. Mast cells (MCs)…”
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Building a microphysiological skin model from induced pluripotent stem cells by Guo, Zongyou, Higgins, Claire A, Gillette, Brian M, Itoh, Munenari, Umegaki, Noriko, Gledhill, Karl, Sia, Samuel K, Christiano, Angela M

“…The discovery of induced pluripotent stem cells (iPSCs) in 2006 was a major breakthrough for regenerative medicine. The establishment of patient-specific iPSCs…”
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Modulation in Proteolytic Activity Is Identified as a Hallmark of Exogen by Transcriptional Profiling of Hair Follicles by Higgins, Claire A., Westgate, Gillian E., Jahoda, Colin A.B.

“…Exogen is the process by which the hair follicle actively sheds its club fiber from the follicle. However, little is known about signals that govern the…”
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A bald statement — Current approaches to manipulate miniaturisation focus only on promoting hair growth by Pantelireis, Nikolaos, Higgins, Claire A.

“…Hair plays a large part in communication and society with its role changing through time and across cultures. Most people do not leave the house before combing…”
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Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition by Xing, Luzhou, Dai, Zhenpeng, Jabbari, Ali, Cerise, Jane E, Higgins, Claire A, Gong, Weijuan, de Jong, Annemieke, Harel, Sivan, DeStefano, Gina M, Rothman, Lisa, Singh, Pallavi, Petukhova, Lynn, Mackay-Wiggan, Julian, Christiano, Angela M, Clynes, Raphael

“…Cytotoxic T cells are necessary and sufficient for the development of alopecia areata in mice, while JAK inhibition promotes regrowth of hair in patients and…”
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Hydrogel-Coated Microneedle Arrays for Minimally Invasive Sampling and Sensing of Specific Circulating Nucleic Acids from Skin Interstitial Fluid by Al Sulaiman, Dana, Chang, Jason Y. H, Bennett, Nitasha R, Topouzi, Helena, Higgins, Claire A, Irvine, Darrell J, Ladame, Sylvain

“…Minimally invasive technologies that can sample and detect cell-free nucleic acid biomarkers from liquid biopsies have recently emerged as clinically useful…”
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Hair Follicle Dermal Cells Support Expansion of Murine and Human Embryonic and Induced Pluripotent Stem Cells and Promote Haematopoiesis in Mouse Cultures by Jahoda, Colin A. B., Hole, Nicholas, Christiano, Angela M., Crawford, Heather, Harris, Susan J., Whitehouse, Jenna C., Higgins, Claire A., Liu, Jun, Lako, Majlinda

“…In the hair follicle, the dermal papilla (DP) and dermal sheath (DS) support and maintain proliferation and differentiation of the epithelial stem cells that…”
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