Search Results - "Higazi, Abd Al Roof"

Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice by Hijazi, Nuha, Abu Fanne, Rami, Abramovitch, Rinat, Yarovoi, Serge, Higazi, Muhamed, Abdeen, Suhair, Basheer, Maamon, Maraga, Emad, Cines, Douglas B., Al-Roof Higazi, Abd

“…Persistent intracerebral hemorrhage (ICH) is a major cause of death and disability after traumatic brain injury (TBI) for which no medical treatment is…”
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Alpha‐defensins: risk factor for thrombosis in COVID‐19 infection by Abdeen, Suhair, Bdeir, Khalil, Abu‐Fanne, Rami, Maraga, Emad, Higazi, Mohamed, Khurram, Nigar, Feldman, Michael, Deshpande, Charuhas, Litzky, Leslie A., Heyman, Samuel N., Montone, Kathleen T., Cines, Douglas B., Higazi, Abd Al‐Roof

“…Summary The inflammatory response to SARS/CoV‐2 (COVID‐19) infection may contribute to the risk of thromboembolic complications. α‐Defensins, antimicrobial…”
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Divergent impacts of tocilizumab and colchicine in COVID‐19‐associated coagulopathy: the role of alpha‐defensins by Abdeen, Suhair, Abu‐Fanne, Rami, Bdeir, Khalil, Maraga, Emad, Higazi, Mohamed, Cines, Douglas B., Heyman, Samuel N., Higazi, Abd Al‐Roof

“…Summary Patients who are severely affected by coronavirus disease 2019 (COVID‐19) may develop a delayed onset ‘cytokine storm’, which includes an increase in…”
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The plasminogen activator system: involvement in central nervous system inflammation and a potential site for therapeutic intervention by Gur-Wahnon, Devorah, Mizrachi, Tehila, Maaravi-Pinto, Florence-Yehudith, Lourbopoulos, Athanasis, Grigoriadis, Nikolaos, Higazi, Abd-Al Roof, Brenner, Talma

“…Extracellular proteases such as plasminogen activators (PAs) and matrix metalloproteinases modulate cell-cell and cell-matrix interactions. Components of the…”
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Characterization of metabolic alterations in the lean metabolically unhealthy alpha defensin transgenic mice by Higazi, Abd Al-Roof, Maraga, Emad, Baraghithy, Saja, Udi, Shiran, Azar, Shahar, Saada, Ann, Glaser, Benjamin, Avrahami, Dana, Abdeen, Suhair, Hamdan, Zenab, Tam, Joseph, Fanne, Rami Abu

“…Inflammation is consistently linked to dysmetabolism. In transgenic mice (Def+/+) model the neutrophilic peptide, alpha defensin, proved atherogenic. This…”
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Opposing effects of HNP1 (α-defensin-1) on plasma cholesterol and atherogenesis by Higazi, Mohamed, Abdeen, Suhair, Abu-Fanne, Rami, Heyman, Samuel N, Masarwy, Aseel, Bdeir, Khalil, Maraga, Emad, Cines, Douglas B, Higazi, Abd Al-Roof

“…Atherosclerosis, the predominant cause of death in well-resourced countries, may develop in the presence of plasma lipid levels within the normal range…”
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Alleviation of Hepatic Steatosis by Alpha-Defensin Is Associated with Enhanced Lipolysis by Maraga, Emad, Safadi, Rifaat, Amer, Johnny, Higazi, Abd Al-Roof, Fanne, Rami Abu

“…: The neutrophilic peptide, alpha-defensin, is considered an evolving risk factor intimately linked with lipid mobilization. It was previously linked to…”
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Blood–brain barrier permeability and tPA-mediated neurotoxicity by Fanne, Rami Abu, Nassar, Taher, Yarovoi, Sergei, Rayan, Anwar, Lamensdorf, Itschak, Karakoveski, Michael, Vadim, Polianski, Jammal, Mahmud, Cines, Douglas B., Al-Roof Higazi, Abd

“…Tissue type plasminogen activator (tPA) can induce neuronal apoptosis, disrupt the blood–brain barrier (BBB), and promote dilation of the cerebral vasculature…”
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Insulin and glucagon share the same mechanism of neuroprotection in diabetic rats: role of glutamate by Fanne, Rami Abu, Nassar, Taher, Heyman, Samuel N, Hijazi, Nuha, Higazi, Abd Al-Roof

“…In patients with acute ischemic stroke, diabetes and hyperglycemia are associated with increased infarct size, more profound neurologic deficits and higher…”
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Regulation of neovascularization by human neutrophil peptides (α‐defensins): a link between inflammation and angiogenesis by Chavakis, Triantafyllos, Cines, Douglas B., Rhee, Joong-Sup, Liang, Olin D., Schubert, Uwe, Hammes, Hans-Peter, Higazi, Abd Al-Roof, Nawroth, Peter P., Preissner, Klaus T., Bdeir, Khalil

“…ABSTRACT Angiogenesis, the growth of new blood vessels, is a complex biological process that is orchestrated by several growth factors and components of the…”
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Neutrophil α-Defensins Cause Lung Injury by Disrupting the Capillary-Epithelial Barrier by BDEIR, Khalil, AL-ROOF HIGAZI, Abd, KULIKOVSKAYA, Irina, CHRISTOFIDOU-SOLOMIDOU, Melpo, VINOGRADOV, Sergei A, ALLEN, Timothy C, IDELL, Steven, LINZMEIER, Rose, GANZ, Tomas, CINES, Douglas B

“…The involvement of neutrophil activation in the sentinel, potentially reversible, events in the pathogenesis of acute lung injury (ALI) is only partially…”
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The fibrinolytic system attenuates vascular tone: effects of tissue plasminogen activator (tPA) and aminocaproic acid on renal microcirculation by Heyman, Samuel N, Hanna, Zohair, Nassar, Taher, Shina, Ahuva, Akkawi, Sa'ed, Goldfarb, Marina, Rosen, Seymour, Higazi, Abd‐Al Roof

“…The renal medulla is a major source of plasminogen activators (PA), recently shown to induce vasodilation in vitro. Treatment with PA inhibitors has been…”
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Urokinase-type Plasminogen Activator (uPA) Induces Pulmonary Microvascular Endothelial Permeability through Low Density Lipoprotein Receptor-related Protein (LRP)-dependent Activation of Endothelial Nitric-oxide Synthase by Makarova, Anastasia M., Lebedeva, Tatiana V., Nassar, Taher, Higazi, Abd Al-Roof, Xue, Jing, Carinato, Maria E., Bdeir, Khalil, Cines, Douglas B., Stepanova, Victoria

“…Urokinase plasminogen activator (uPA) and PA inhibitor type 1 (PAI-1) are elevated in acute lung injury, which is characterized by a loss of endothelial…”
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Neutralizing the neurotoxic effects of exogenous and endogenous tPA by Armstead, William M, Nassar, Taher, Akkawi, Saed, Smith, Douglas H, Chen, Xiao-Han, Cines, Douglas B, Higazi, Abd Al-Roof

“…The clinical use of tissue-type plasminogen activator (tPA) in the treatment of stroke is profoundly constrained by its serious side effects. We report that…”
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In vitro and in vivo effects of tPA and PAI-1 on blood vessel tone by Nassar, Taher, Akkawi, Sa’ed, Shina, Ahuva, Haj-Yehia, Abdullah, Bdeir, Khalil, Tarshis, Mark, Heyman, Samuel N., Higazi, Abd Al-Roof

“…Tissue type plasminogen activator (tPA) is a key enzyme in the fibrinolytic cascade. In this paper we report that tPA contains 2 independent epitopes that…”
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Platelet Factor 4 Enhances the Binding of Oxidized Low-density Lipoprotein to Vascular Wall Cells by Nassar, Taher, Sachais, Bruce S, Akkawi, Sa'ed, Kowalska, Maria Anna, Bdeir, Khalil, Leitersdorf, Eran, Hiss, Edna, Ziporen, Leah, Aviram, Michael, Cines, Douglas, Poncz, Mortimer, Higazi, Abd Al-Roof

“…Accumulation of low-density lipoprotein (LDL)-derived cholesterol by macrophages in vessel walls is a pathogenomic feature of atherosclerotic lesions…”
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ACE2, COVID-19 Infection, Inflammation, and Coagulopathy: Missing Pieces in the Puzzle by Abassi, Zaid, Higazi, Abd Al Roof, Kinaneh, Safa, Armaly, Zaher, Skorecki, Karl, Heyman, Samuel N

“…Engulfed by the grave consequences of the coronavirus disease 2019 (COVID-19) pandemic, a better understanding of the unique pattern of viral invasion and…”
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Role of tissue plasminogen activator in clinical aggravation of experimental autoimmune encephalomyelitis and its therapeutic potential by Mizrachi, Tehila, Gur-Wahnon, Devorah, Al-Roof Higazi, Abd, Brenner, Talma

“…•Tissue plasminogen activator (tPA) has immunomodulatory effect in EAE.•Absence of tPA aggravate EAE, while administration of tPA ameliorate the…”
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Release of IL-6 After Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis Through NMDA Receptor Activation and Upregulation of ET-1 and JNK by Armstead, William M., Hekierski, Hugh, Pastor, Philip, Yarovoi, Serge, Higazi, Abd Al-Roof, Cines, Douglas B.

“…The sole FDA-approved drug treatment for ischemic stroke is tissue-type plasminogen activator (tPA). However, upregulation of JNK mitogen-activated protein…”
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Platelet factor 4 binds to low-density lipoprotein receptors and disrupts the endocytic itinerary, resulting in retention of low-density lipoprotein on the cell surface by Sachais, Bruce S., Kuo, Alice, Nassar, Taher, Morgan, Jeanelle, Kariko, Katalin, Williams, Kevin Jon, Feldman, Michael, Aviram, Michael, Shah, Neelima, Jarett, Leonard, Poncz, Mortimer, Cines, Douglas B., Higazi, Abd Al-Roof

“…The influence of platelets on the cellular metabolism of atherogenic lipoproteins has not been characterized in detail. Therefore, we investigated the effect…”
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