Effects of Water-Soluble Hemicellulose from Soybean Hull on Serum Antibody Levels and Activation of Macrophages in Rats

Effects of Water-Soluble Hemicellulose from Soybean Hull on Serum Antibody Levels and Activation of Macrophages in Rats

Effects of soybean hull water-soluble hemicellulose (WSHC) on serum immunoglobulin (Ig) concentration and production of NO and IL-1β from peritoneal macrophages were examined and compared with those of Agaricus blazei in the rat system. WSHC consisted of arabinose, galactose, xylose, glucose, and rh...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry Vol. 49; no. 10; pp. 4965 - 4970
Main Authors: Nagata, Jun-ichi, Higashiuesato, Yutaka, Maeda, Goki, Chinen, Isao, Saito, Morio, Iwabuchi, Kazuya, Onoē, Kazunori
Format: Journal Article
Language:English
Published: Washington, DC American Chemical Society 01-10-2001
Subjects:
Agaricus - chemistry
Animals
Antibodies - blood
Arabinose - analysis
Biological and medical sciences
Body Weight
Galactose - analysis
General pharmacology
Glucose - analysis
Glycine max - chemistry
Macrophage Activation - drug effects
Macrophages, Peritoneal - drug effects
Macrophages, Peritoneal - immunology
Male
Medical sciences
Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
Pharmacology. Drug treatments
Plant Structures - chemistry
Polysaccharides - chemistry
Polysaccharides - isolation & purification
Polysaccharides - pharmacology
Rats
Rats, Wistar
Rhamnose - analysis
Solubility
Water
Xylose - analysis
Hemicellulose
Immune response
Rat
Rodentia
IgG
Interleukin 1β
Water soluble compound
Vertebrata
Mammalia
Laboratory animal
Polysaccharide
Humoral immunity
Macrophage
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Summary:Effects of soybean hull water-soluble hemicellulose (WSHC) on serum immunoglobulin (Ig) concentration and production of NO and IL-1β from peritoneal macrophages were examined and compared with those of Agaricus blazei in the rat system. WSHC consisted of arabinose, galactose, xylose, glucose, and rhamnose, and the molecular weight was ∼500000. Rats were ip administrated each sample at a dose of 0.67, 13.4, or 26.9 mg/kg/day for 14 days. The administration of WSHC resulted in significantly higher productions of IgM (p < 0.01 on day 6, p < 0.05 on day 14) and IgG (p < 0.05 on day 6) than those in other groups. When peritoneal macrophages were stimulated with various concentrations of sample (0.67, 13.4, or 26.9 mg/mL), WSHC significantly increased both NO and IL-1β productions only at the concentration of 13.4 (mg/mL) compared with those of a saline group. These findings demonstrate that WSHC enhances humoral immunity and activation of macrophages, thereby leading to the augmentation of immune responses in rats. Keywords: Rat immunoglobulin; soybean hull; water-soluble hemicellulose; rat peritoneal macrophage
Bibliography:ark:/67375/TPS-1GPX2FVL-F
istex:866C42B76AF70A77DB686CA02CC46A79C88044D3
ObjectType-Article-2
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content type line 23
ISSN:0021-8561
1520-5118
DOI:10.1021/jf0104883