Search Results - "Higashibata, Akira"
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Effectiveness of endothelial progenitor cell culture under microgravity for improved angiogenic potential
Published in Scientific reports (24-09-2018)“…Endothelial progenitor cell (EPC) transplantation is beneficial for ischemic diseases such as critical limb ischemia and ischemic heart disease. The scarcity…”
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Muscle synergies of multidirectional postural control in astronauts on Earth after a long-term stay in space
Published in Journal of neurophysiology (01-05-2022)“…Movements of the human biological system have adapted to the physical environment under the 1-g gravitational force on Earth. However, the effects of…”
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Gravitropism interferes with hydrotropism via counteracting auxin dynamics in cucumber roots: clinorotation and spaceflight experiments
Published in The New phytologist (01-09-2017)“…Roots of land plants show gravitropism and hydrotropism in response to gravity and moisture gradients, respectively, for controlling their growth orientation…”
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Ubiquitin Ligase Cbl-b Is a Negative Regulator for Insulin-Like Growth Factor 1 Signaling during Muscle Atrophy Caused by Unloading
Published in Molecular and Cellular Biology (01-09-2009)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Reactive oxygen species upregulate expression of muscle atrophy-associated ubiquitin ligase Cbl-b in rat L6 skeletal muscle cells
Published in American Journal of Physiology: Cell Physiology (01-06-2018)“…Unloading-mediated muscle atrophy is associated with increased reactive oxygen species (ROS) production. We previously demonstrated that elevated ubiquitin…”
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Changes in mitochondrial homeostasis and redox status in astronauts following long stays in space
Published in Scientific reports (16-12-2016)“…The effects of long-term exposure to extreme space conditions on astronauts were investigated by analyzing hair samples from ten astronauts who had spent six…”
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Comparative Analysis of Muscle Atrophy During Spaceflight, Nutritional Deficiency and Disuse in the Nematode Caenorhabditis elegans
Published in International journal of molecular sciences (10-08-2023)“…While spaceflight is becoming more common than before, the hazards spaceflight and space microgravity pose to the human body remain relatively unexplored…”
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Root-tip-mediated inhibition of hydrotropism is accompanied with the suppression of asymmetric expression of auxin-inducible genes in response to moisture gradients in cucumber roots
Published in PloS one (11-01-2018)“…In cucumber seedlings, gravitropism interferes with hydrotropism, which results in the nearly complete inhibition of hydrotropism under stationary conditions…”
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Findings from recent studies by the Japan Aerospace Exploration Agency examining musculoskeletal atrophy in space and on Earth
Published in NPJ microgravity (26-05-2021)“…The musculoskeletal system provides the body with correct posture, support, stability, and mobility. It is composed of the bones, muscles, cartilage, tendons,…”
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Author Correction: Changes in mitochondrial homeostasis and redox status in astronauts following long stays in space
Published in Scientific reports (20-04-2020)“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Suppression of Hydroxycinnamate Network Formation in Cell Walls of Rice Shoots Grown under Microgravity Conditions in Space
Published in PloS one (17-09-2015)“…Network structures created by hydroxycinnamate cross-links within the cell wall architecture of gramineous plants make the cell wall resistant to the…”
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Histone deacetylase HDA-4-mediated epigenetic regulation in space-flown C. elegans
Published in NPJ microgravity (01-09-2021)“…Epigenetic changes during long-term spaceflight are beginning to be studied by NASA’s twin astronauts and other model organisms. Here, we evaluate the…”
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Persistence of plant hormone levels in rice shoots grown under microgravity conditions in space: its relationship to maintenance of shoot growth
Published in Physiologia plantarum (01-10-2017)“…We investigated the effects of microgravity environment on growth and plant hormone levels in dark‐grown rice shoots cultivated in artificial 1 g and…”
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Regulation of asymmetric polar auxin transport by PsPIN1 in endodermal tissues of etiolated Pisum sativum epicotyls: focus on immunohistochemical analyses
Published in Journal of plant research (01-07-2018)“…This manuscript reports the production of specific polyclonal antibodies for PsPIN1, a putative auxin efflux carrier in Alaska pea ( Pisum sativum L.) plants,…”
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Effects of a Closed Space Environment on Gene Expression in Hair Follicles of Astronauts in the International Space Station
Published in PloS one (30-03-2016)“…Adaptation to the space environment can sometimes pose physiological problems to International Space Station (ISS) astronauts after their return to earth…”
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Evaluating the long-term effect of space radiation on the reproductive normality of mammalian sperm preserved on the International Space Station
Published in Science advances (01-06-2021)“…The effect of space radiation on offspring was evaluated using mouse freeze-dried spermatozoa preserved on the Space Station. Space radiation may cause DNA…”
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Loss of physical contact in space alters the dopamine system in C. elegans
Published in iScience (18-02-2022)“…Progressive neuromuscular decline in microgravity is a prominent health concern preventing interplanetary human habitation. We establish functional…”
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Correction: Effects of a Closed Space Environment on Gene Expression in Hair Follicles of Astronauts in the International Space Station
Published in PloS one (18-05-2016)“…[This corrects the article DOI: 10.1371/journal.pone.0150801.]…”
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Unloading stress disturbs muscle regeneration through perturbed recruitment and function of macrophages
Published in Journal of applied physiology (1985) (15-05-2012)“…Skeletal muscle is one of the most sensitive tissues to mechanical loading, and unloading inhibits the regeneration potential of skeletal muscle after injury…”
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Microgravity elicits reproducible alterations in cytoskeletal and metabolic gene and protein expression in space-flown Caenorhabditis elegans
Published in NPJ microgravity (21-01-2016)“…Although muscle atrophy is a serious problem during spaceflight, little is known about the sequence of molecular events leading to atrophy in response to…”
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