Search Results - "Hiemstra, P. S."

Pulmonary immune responses against SARS-CoV-2 infection: harmful or not? by Guillon, A., Hiemstra, P. S., Si-Tahar, M.

“…Although our knowledge of the pulmonary immune response in patients with SARS-CoV-2 infection is still limited, intensivists will be offered to prescribe…”
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Innate immunity in the lung: how epithelial cells fight against respiratory pathogens by Bals, R, Hiemstra, P.S

“…The human lung is exposed to a large number of airborne pathogens as a result of the daily inhalation of 10,000 litres of air. The observation that respiratory…”
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Interleukin 13 Exposure Enhances Vitamin D-Mediated Expression of the Human Cathelicidin Antimicrobial Peptide 18/LL-37 in Bronchial Epithelial Cells by SCHRUMPF, J. A, STERKENBURG, M. A. J. A. Van, VERHOOSEL, R. M, ZUYDERDUYN, S, HIEMSTRA, P. S

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Interleukin-8 stimulates cell proliferation in non-small cell lung cancer through epidermal growth factor receptor transactivation by Luppi, F, Longo, A.M, de Boer, W.I, Rabe, K.F, Hiemstra, P.S

“…Summary Interleukin-8 (IL-8; CXCL8) is a cytokine of the CXC chemokine family that is involved in neutrophil recruitment and activation. In addition, IL-8 has…”
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Muscarinic M3 receptor stimulation increases cigarette smoke-induced IL-8 secretion by human airway smooth muscle cells by Gosens, R, Rieks, D, Meurs, H, Ninaber, D. K, Rabe, K. F, Nanninga, J, Kolahian, S, Halayko, A. J, Hiemstra, P. S, Zuyderduyn, S

“…Acetylcholine is the primary parasympathetic neurotransmitter in the airways and is known to cause bronchoconstriction and mucus secretion. Recent findings…”
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Eosinophils in bronchial mucosa of asthmatics after allergen challenge: effect of anti-IgE treatment by van Rensen, E.L.J, Evertse, C.E, van Schadewijk, W.A.A.M, van Wijngaarden, S, Ayre, G, Mauad, T, Hiemstra, P.S, Sterk, P.J, Rabe, K.F

“…Anti-IgE, omalizumab, inhibits the allergen response in patients with asthma. This has not been directly related to changes in inflammatory conditions. We…”
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Serum periostin does not reflect type 2-driven inflammation in COPD by Carpaij, O A, Muntinghe, F O W, Wagenaar, M B, Habing, J W, Timens, W, Kerstjens, H A M, Nawijn, M C, Kunz, L I Z, Hiemstra, P S, Tew, G W, Holweg, C T J, Brandsma, C A, van den Berge, M

“…Although Th2 driven inflammation is present in COPD, it is not clearly elucidated which COPD patients are affected. Since periostin is associated with Th2…”
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Relation between duration of smoking cessation and bronchial inflammation in COPD by Lapperre, T S, Postma, D S, Gosman, M M E, Snoeck-Stroband, J B, ten Hacken, N H T, Hiemstra, P S, Timens, W, Sterk, P J, Mauad, T

“…Background: Chronic obstructive pulmonary disease (COPD) is associated with airway inflammation. Although smoking cessation improves symptoms and the decline…”
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The Microbiome in Bronchial Biopsies from Smokers and Ex-Smokers with Stable COPD - A Metatranscriptomic Approach by Ditz, B., Boekhoudt, J., Couto, N., Brandsma, C. A., Hiemstra, P. S., Tew, G. W., Neighbors, M., Grimbaldeston, M. A., Timens, W., Kerstjens, H. A. M., Rossen, J. W. A., Guryev, V., van den Berge, M., Faiz, A.

“…Current knowledge about the respiratory microbiome is mainly based on 16S ribosomal RNA gene sequencing. Newer sequencing approaches, such as…”
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Microarray Gene Expression Analysis to Evaluate Cell Type Specific Expression of Targets Relevant for Immunotherapy of Hematological Malignancies by Pont, M J, Honders, M W, Kremer, A N, van Kooten, C, Out, C, Hiemstra, P S, de Boer, H C, Jager, M J, Schmelzer, E, Vries, R G, Al Hinai, A S, Kroes, W G, Monajemi, R, Goeman, J J, Böhringer, S, Marijt, W A F, Falkenburg, J H F, Griffioen, M

“…Cellular immunotherapy has proven to be effective in the treatment of hematological cancers by donor lymphocyte infusion after allogeneic hematopoietic stem…”
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Corrigendum: Cigarette smoke restricts the ability of mesenchymal cells to support lung epithelial organoid formation by Khedoe, P P S J, van Schadewijk, W A A M, Schwiening, M, Ng-Blichfeldt, J P, Marciniak, S J, Stolk, J, Gosens, R, Hiemstra, P S

“…[This corrects the article DOI: 10.3389/fcell.2023.1165581.]…”
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Novel roles of protease inhibitors in infection and inflammation by Hiemstra, P S

“…The local balance between proteinase inhibitors and proteinases determines local proteolytic activity. Various studies have demonstrated the importance of…”
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Cigarette smoke restricts the ability of mesenchymal cells to support lung epithelial organoid formation by Khedoe, P P S J, van Schadewijk, W A A M, Schwiening, M, Ng-Blichfeldt, J P, Marciniak, S J, Stolk, J, Gosens, R, Hiemstra, P S

“…Adequate lung epithelial repair relies on supportive interactions within the epithelial niche, including interactions with WNT-responsive fibroblasts. In…”
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Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD by Song, J, Heijink, I H, Kistemaker, L E M, Reinders-Luinge, M, Kooistra, W, Noordhoek, J A, Gosens, R, Brandsma, C A, Timens, W, Hiemstra, P S, Rots, M G, Hylkema, M N

“…Goblet cell metaplasia, a common feature of chronic obstructive pulmonary disease (COPD), is associated with mucus hypersecretion which contributes to the…”
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Enhanced pulmonary leptin expression in patients with severe COPD and asymptomatic smokers by Vernooy, J H J, Drummen, N E A, van Suylen, R J, Cloots, R H E, Möller, G M, Bracke, K R, Zuyderduyn, S, Dentener, M A, Brusselle, G G, Hiemstra, P S, Wouters, E F M

“…Chronic obstructive pulmonary disease (COPD) is characterised by an abnormal inflammatory reaction of the lungs involving activation of epithelial cells…”
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Regulation of YKL-40 expression by corticosteroids: effect on pro-inflammatory macrophages in vitro and its modulation in COPD in vivo by Kunz, L I Z, van't Wout, E F A, van Schadewijk, A, Postma, D S, Kerstjens, H A M, Sterk, P J, Hiemstra, P S

“…Macrophages constitute a heterogeneous cell population with pro- (MΦ1) and anti-inflammatory (MΦ2) cells. The soluble chitinase-like-protein YKL-40 is…”
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Effect of diesel exhaust generated by a city bus engine on stress responses and innate immunity in primary bronchial epithelial cell cultures by Zarcone, M.C., Duistermaat, E., Alblas, M.J., van Schadewijk, A., Ninaber, D.K., Clarijs, V., Moerman, M.M., Vaessen, D., Hiemstra, P.S., Kooter, I.M.

“…Harmful effects of diesel emissions can be investigated via exposures of human epithelial cells, but most of previous studies have largely focused on the use…”
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Antibacterial activity of antileukoprotease by HIEMSTRA, P. S, MAASSEN, R. J, STOLK, J, HEINZEL-WIELAND, R, STEFFENS, G. J, DIJKMAN, J. H

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Small airways function and molecular markers in exhaled air in mild asthma by Battaglia, S, den Hertog, H, Timmers, M C, Lazeroms, S P G, Vignola, A M, Rabe, K F, Bellia, V, Hiemstra, P S, Sterk, P J

“…Background: Several studies suggest that the periphery of the lung is the major site of inflammation in asthma. Fractional exhaled nitric oxide (Feno) and…”
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Increased number of B-cells in bronchial biopsies in COPD by Gosman, M. M. E, Willemse, B. W. M, Jansen, D. F, Lapperre, T. S, van Schadewijk, A, Hiemstra, P. S, Postma, D. S, Timens, W, Kerstjens, H. A. M, Groningen and Leiden Universities Corticosteroids in Obstructive Lung Disease (GLUCOLD) Study Group

“…Recently, it has been shown that the accumulated volume of B-cells in small airways is increased in chronic obstructive pulmonary disease (COPD) Global…”
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