Search Results - "Hiemke, Christoph"

Concentration-Effect Relationships of Psychoactive Drugs and the Problem to Calculate Therapeutic Reference Ranges by Hiemke, Christoph

“…Despite the obvious potential of Therapeutic Drug Monitoring (TDM) as a tool to optimize psychopharmacotherapy, especially treatment with mood-stabilizing,…”
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Consensus Guideline Based Therapeutic Drug Monitoring (TDM) in Psychiatry and Neurology by Hiemke, Christoph

“…Therapeutic drug monitoring (TDM) is a valuable tool for tailoring the dosage of the prescribed medication(s) to the individual pharmacokinetic characteristics…”
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Buprenorphine–cannabis interaction in patients undergoing opioid maintenance therapy by Vierke, Christopher, Marxen, Brigitte, Boettcher, Michael, Hiemke, Christoph, Havemann-Reinecke, Ursula

“…Buprenorphine is a partial μ-opioid agonist widely used for opioid maintenance therapy (OMT). It is mainly metabolized to pharmacologically active…”
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Safety of psychotropic medications in people with COVID-19: evidence review and practical recommendations by Ostuzzi, Giovanni, Papola, Davide, Gastaldon, Chiara, Schoretsanitis, Georgios, Bertolini, Federico, Amaddeo, Francesco, Cuomo, Alessandro, Emsley, Robin, Fagiolini, Andrea, Imperadore, Giuseppe, Kishimoto, Taishiro, Michencigh, Giulia, Nosé, Michela, Purgato, Marianna, Dursun, Serdar, Stubbs, Brendon, Taylor, David, Thornicroft, Graham, Ward, Philip B, Hiemke, Christoph, Correll, Christoph U, Barbui, Corrado

“…The novel coronavirus pandemic calls for a rapid adaptation of conventional medical practices to meet the evolving needs of such vulnerable patients. People…”
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Assessing Pharmacokinetic Correlates of Escitalopram-Related Adverse Drug Reactions by Kuzin, Maxim, Haen, Ekkehard, Kuzo, Nazar, Endres, Katharina, Hiemke, Christoph, Paulzen, Michael, Schoretsanitis, Georgios

“…To assess the pharmacokinetic correlates of reported adverse drug reactions (ADRs) under antidepressant treatment with escitalopram (ESC) using a large…”
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Potentially inappropriate medication in older psychiatric patients by Hefner, Gudrun, Hahn, Martina, Toto, Sermin, Hiemke, Christoph, Roll, Sibylle C., Wolff, Jan, Klimke, Ansgar

“…Purpose Many psychotropic drugs are listed as potentially inappropriate medication (PIM) in the older population. Potentially inappropriate means that…”
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Astroglial Plasticity in the Hippocampus is Affected by Chronic Psychosocial Stress and Concomitant Fluoxetine Treatment by CZEH, Boldizsar, SIMON, Maria, SCHMELTING, Barthel, HIEMKE, Christoph, FUCHS, Eberhard

“…Analysis of post-mortem tissue from patients with affective disorders has revealed a decreased number of glial cells in several brain areas. Here, we examined…”
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Levomethadone Therapeutic Drug Monitoring to Aid Opioid Withdrawal Therapy: A Short Communication by Pfeifer, Philippe, Hildebrand, Kathrin, Angelov, Andreas, Havemann-Reinecke, Ursula, Böttcher, Michael, Hiemke, Christoph, Prentice, Tatjana, Roll, Sibylle C

“…Therapeutic drug monitoring (TDM) is recommended for opioid maintenance therapy with levomethadone. However, TDM has not yet been applied to monitor opioid…”
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Chronic psychosocial stress and citalopram modulate the expression of the glial proteins GFAP and NDRG2 in the hippocampus by Araya-Callís, Carolina, Hiemke, Christoph, Abumaria, Nashat, Flugge, Gabriele

“…Rationale It has been suggested that there are causal relationships between alterations in brain glia and major depression. Objectives To investigate whether a…”
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Pharmacotherapy, drug-drug interactions and potentially inappropriate medication in depressive disorders by Wolff, Jan, Reißner, Pamela, Hefner, Gudrun, Normann, Claus, Kaier, Klaus, Binder, Harald, Hiemke, Christoph, Toto, Sermin, Domschke, Katharina, Marschollek, Michael, Klimke, Ansgar

“…Introduction The aim of this study was to describe the number and type of drugs used to treat depressive disorders in inpatient psychiatry and to analyse the…”
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Body mass index as a determinant of clozapine plasma concentrations: A pharmacokinetic-based hypothesis by Kuzin, Maxim, Haen, Ekkehard, Hiemke, Christoph, Bochon, Benjamin, Bochon, Karolina, Gründer, Gerhard, Paulzen, Michael, Schoretsanitis, Georgios

“…Background: Knowledge regarding the impact of body composition measures on pharmacokinetics of antipsychotics is limited. Aims: Our aim was to investigate the…”
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Therapeutic Reference Range for Aripiprazole in Schizophrenia Revised: a Systematic Review and Metaanalysis by Hart, Xenia M., Hiemke, Christoph, Eichentopf, Luzie, Lense, Xenija M., Clement, Hans Willi, Conca, Andreas, Faltraco, Frank, Florio, Vincenzo, Grüner, Jessica, Havemann-Reinecke, Ursula, Molden, Espen, Paulzen, Michael, Schoretsanitis, Georgios, Riemer, Thomas G., Gründer, Gerhard

“…Rationale While one of the basic axioms of pharmacology postulates that there is a relationship between the concentration and effects of a drug, the value of…”
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Therapeutic Reference Ranges for Psychotropic Drugs: A Protocol for Systematic Reviews by Hart, Xenia M, Eichentopf, Luzie, Lense, Xenija, Riemer, Thomas, Wesner, Katja, Hiemke, Christoph, Gründer, Gerhard

“…For many psychotropic drugs, monitoring of drug concentrations in the blood (Therapeutic Drug Monitoring; TDM) has been proven useful to individualize…”
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TDM in psychiatry and neurology: A comprehensive summary of the consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology, update 2017; a tool for clinicians by Schoretsanitis, Georgios, Paulzen, Michael, Unterecker, Stefan, Schwarz, Markus, Conca, Andreas, Zernig, Gerald, Gründer, Gerhard, Haen, Ekkerhard, Baumann, Pierre, Bergemann, Niels, Clement, Hans Willi, Domschke, Katharina, Eckermann, Gabriel, Egberts, Karin, Gerlach, Manfred, Greiner, Christine, Havemann-Reinecke, Ursula, Hefner, Gudrun, Helmer, Renate, Janssen, Ger, Jaquenoud-Sirot, Eveline, Laux, Gerd, Messer, Thomas, Mössner, Rainald, Müller, Matthias J., Pfuhlmann, Bruno, Riederer, Peter, Saria, Alois, Schoppek, Bernd, Silva Gracia, Margarete, Stegmann, Benedikt, Steimer, Werner, Stingl, Julia C., Uhr, Manfred, Ulrich, Sven, Waschgler, Roland, Zurek, Gabriela, Hiemke, Christoph

“…Objectives: Therapeutic drug monitoring (TDM) combines the quantification of drug concentrations in blood, pharmacological interpretation and treatment…”
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Clinical response in patients treated with once-monthly paliperidone palmitate: analysis of a therapeutic drug monitoring (TDM) database by Schoretsanitis, Georgios, Haen, Ekkehard, Piacentino, Daria, Conca, Andreas, Endres, Katharina, Hiemke, Christoph, Gründer, Gerhard, Paulzen, Michael

“…To investigate pharmacokinetic correlates of clinical response in patients treated with once-monthly paliperidone palmitate (PP1M) injections at steady state…”
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Body mass index (BMI) but not body weight is associated with changes in the metabolism of risperidone; a pharmacokinetics-based hypothesis by Paulzen, Michael, Haen, Ekkehard, PhD, Stegmann, Benedikt, PhD, Hiemke, Christoph, PhD, Gründer, Gerhard, Lammertz, Sarah E., PhD, Schoretsanitis, Georgios

“…Highlights • Body weight was shown to be a pharmacokinetic irrelevant parameter for risperidone. • BMI correlated positively with active metabolite and active…”
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Pharmacokinetics of selective serotonin reuptake inhibitors by Hiemke, Christoph, Härtter, Sebastian

“…The five selective serotonin reuptake inhibitors (SSRIs), fluoxetine, fluvoxamine, paroxetine, sertraline, and citalopram, have similar antidepressant efficacy…”
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Chronic Social Stress Inhibits Cell Proliferation in the Adult Medial Prefrontal Cortex: Hemispheric Asymmetry and Reversal by Fluoxetine Treatment by Czéh, Boldizsár, Müller-Keuker, Jeanine I H, Rygula, Rafal, Abumaria, Nashat, Hiemke, Christoph, Domenici, Enrico, Fuchs, Eberhard

“…Profound neuroplastic changes have been demonstrated in various limbic structures after chronic stress exposure and antidepressant treatment in animal models…”
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Predicting the risk of drug–drug interactions in psychiatric hospitals: a retrospective longitudinal pharmacovigilance study by Wolff, Jan, Hefner, Gudrun, Normann, Claus, Kaier, Klaus, Binder, Harald, Domschke, Katharina, Hiemke, Christoph, Marschollek, Michael, Klimke, Ansgar

“…ObjectivesThe aim was to use routine data available at a patient’s admission to the hospital to predict polypharmacy and drug–drug interactions (DDI) and to…”
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Therapeutic drug monitoring for antidepressant drug treatment by Ostad Haji, Elnaz, Hiemke, Christoph, Pfuhlmann, Bruno

“…The aim of antidepressant drug treatment is to produce remission without causing adverse effects during the acute phase of the illness and to prevent relapses…”
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