Search Results - "Hieke, Nora"

FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates by Schlütermann, David, Berleth, Niklas, Deitersen, Jana, Wallot-Hieke, Nora, Friesen, Olena, Wu, Wenxian, Stuhldreier, Fabian, Sun, Yadong, Berning, Lena, Friedrich, Annabelle, Mendiburo, María José, Peter, Christoph, Wiek, Constanze, Hanenberg, Helmut, Stefanski, Anja, Stühler, Kai, Stork, Björn

“…The protein kinase TBK1 is a central regulator of innate immune responses and autophagy, and ablation of either function has been linked to neuroinflammatory…”
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Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells by Hieke, Nora, Löffler, Antje S, Kaizuka, Takeshi, Berleth, Niklas, Böhler, Philip, Drießen, Stefan, Stuhldreier, Fabian, Friesen, Olena, Assani, Kaivon, Schmitz, Katharina, Peter, Christoph, Diedrich, Britta, Dengjel, Jörn, Holland, Petter, Simonsen, Anne, Wesselborg, Sebastian, Mizushima, Noboru, Stork, Björn

“…Autophagy describes an intracellular process responsible for the lysosome-dependent degradation of cytosolic components. The ULK1/2 complex comprising the…”
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Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy by Drießen, Stefan, Berleth, Niklas, Friesen, Olena, Löffler, Antje S, Böhler, Philip, Hieke, Nora, Stuhldreier, Fabian, Peter, Christoph, Schink, Kay O, Schultz, Sebastian W, Stenmark, Harald, Holland, Petter, Simonsen, Anne, Wesselborg, Sebastian, Stork, Björn

“…Autophagy represents an intracellular degradation process which is involved in both regular cell homeostasis and disease settings. In recent years, the…”
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The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death by Wu, Wenxian, Wang, Xiaojing, Berleth, Niklas, Deitersen, Jana, Wallot-Hieke, Nora, Böhler, Philip, Schlütermann, David, Stuhldreier, Fabian, Cox, Jan, Schmitz, Katharina, Seggewiß, Sabine, Peter, Christoph, Kasof, Gary, Stefanski, Anja, Stühler, Kai, Tschapek, Astrid, Gödecke, Axel, Stork, Björn

“…Autophagy, apoptosis, and necroptosis are stress responses governing the ultimate fate of a cell. However, the crosstalk between these cellular stress…”
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Systematic analysis of ATG13 domain requirements for autophagy induction by Wallot-Hieke, Nora, Verma, Neha, Schlütermann, David, Berleth, Niklas, Deitersen, Jana, Böhler, Philip, Stuhldreier, Fabian, Wu, Wenxian, Seggewiß, Sabine, Peter, Christoph, Gohlke, Holger, Mizushima, Noboru, Stork, Björn

“…Macroautophagy/autophagy is an evolutionarily conserved cellular process whose induction is regulated by the ULK1 protein kinase complex. The subunit ATG13…”
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Effect of yggG gene knockout on the acetic acid assimilation in Escherichia coli by Ojima, Yoshihiro, Fukuda, Yuto, Shirasaka, Nobuya, Hieke, Nora, Nishioka, Motomu, Taya, Masahito

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TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy by Wu, Wenxian, Wang, Xiaojing, Sun, Yadong, Berleth, Niklas, Deitersen, Jana, Schlütermann, David, Stuhldreier, Fabian, Wallot-Hieke, Nora, José Mendiburo, María, Cox, Jan, Peter, Christoph, Bergmann, Ann Kathrin, Stork, Björn

“…Macroautophagy/autophagy and necroptosis represent two opposing cellular s tress responses. Whereas autophagy primarily fulfills a cyto-protective function,…”
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Targeting urothelial carcinoma cells by combining cisplatin with a specific inhibitor of the autophagy-inducing class III PtdIns3K complex by Schlütermann, David, Skowron, Margaretha A., Berleth, Niklas, Böhler, Philip, Deitersen, Jana, Stuhldreier, Fabian, Wallot-Hieke, Nora, Wu, Wenxian, Peter, Christoph, Hoffmann, Michèle J., Niegisch, Günter, Stork, Björn

“…Cisplatin-based regimens are routinely employed for the treatment of urothelial carcinoma. However, therapeutic success is hampered by the primary presence of…”
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The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane by Böhler, Philip, Stuhldreier, Fabian, Anand, Ruchika, Kondadi, Arun Kumar, Schlütermann, David, Berleth, Niklas, Deitersen, Jana, Wallot-Hieke, Nora, Wu, Wenxian, Frank, Marian, Niemann, Hendrik, Wesbuer, Elisabeth, Barbian, Andreas, Luyten, Tomas, Parys, Jan B., Weidtkamp-Peters, Stefanie, Borchardt, Andrea, Reichert, Andreas S., Peña-Blanco, Aida, García-Sáez, Ana J., Itskanov, Samuel, van der Bliek, Alexander M., Proksch, Peter, Wesselborg, Sebastian, Stork, Björn

“…Mitochondria are cellular organelles with crucial functions in the generation and distribution of ATP, the buffering of cytosolic Ca 2+ and the initiation of…”
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Impact of allicin on macrophage activity by Haase, Hajo, Hieke, Nora, Plum, Laura M., Gruhlke, Martin C.H., Slusarenko, Alan J., Rink, Lothar

“…► Allicin showed comparable toxicity toward Escherichia coli and Raw 264.7 murine macrophages. ► In Raw 264.7, allicin inhibits NO production, but not…”
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Systematic analysis of ATG13 domain requirements for autophagy induction by Wallot-Hieke, Nora, Verma, Neha, Schlütermann, David, Berleth, Niklas, Deitersen, Jana, Böhler, Philip, Stuhldreier, Fabian, Wu, Wenxian, Seggewiß, Sabine, Peter, Christoph, Gohlke, Holger, Mizushima, Noboru, Stork, Björn

“…Macroautophagy/autophagy is an evolutionarily conserved cellular process whose induction is regulated by the ULK1 protein kinase complex. The subunit ATG13…”
Get full text

Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells by Hieke, Nora, Löffler, Antje S, Kaizuka, Takeshi, Berleth, Niklas, Böhler, Philip, Drießen, Stefan, Stuhldreier, Fabian, Friesen, Olena, Assani, Kaivon, Schmitz, Katharina, Peter, Christoph, Diedrich, Britta, Dengjel, Jörn, Holland, Petter, Simonsen, Anne, Wesselborg, Sebastian, Mizushima, Noboru, Stork, Björn

“…Autophagy describes an intracellular process responsible for the lysosome-dependent degradation of cytosolic components. The ULK1/2 complex comprising the…”
Get full text

Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy by Drießen, Stefan, Berleth, Niklas, Friesen, Olena, Löffler, Antje S, Böhler, Philip, Hieke, Nora, Stuhldreier, Fabian, Peter, Christoph, Schink, Kay O, Schultz, Sebastian W, Stenmark, Harald, Holland, Petter, Simonsen, Anne, Wesselborg, Sebastian, Stork, Björn

“…Autophagy represents an intracellular degradation process which is involved in both regular cell homeostasis and disease settings. In recent years, the…”
Get full text