Search Results - "Hideki Mochida"

Avanafil, a potent and highly selective phosphodiesterase-5 inhibitor for erectile dysfunction by Kotera, Jun, Mochida, Hideki, Inoue, Hirotaka, Noto, Tsunehisa, Fujishige, Kotomi, Sasaki, Takashi, Kobayashi, Tamaki, Kojima, Koki, Yee, Shiyin, Yamada, Yasuhiro, Kikkawa, Kohei, Omori, Kenji

“…We investigated the in vitro inhibitory effects of avanafil, a novel, potent inhibitor of phosphodiesterase-5, on 11 phosphodiesterases. We also studied its…”
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Beneficial effects of soluble epoxide hydrolase inhibitors in myocardial infarction model: Insight gained using metabolomic approaches by Li, Ning, Liu, Jun-Yan, Timofeyev, Valeriy, Qiu, Hong, Hwang, Sung Hee, Tuteja, Dipika, Lu, Ling, Yang, Jun, Mochida, Hideki, Low, Reginald, Hammock, Bruce D, Chiamvimonvat, Nipavan

“…Abstract Myocardial infarction (MI) leading to myocardial cell loss represents one of the common causes leading to cardiac failure. We have previously…”
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Effects of aging and uninephrectomy on renal changes in Tsukuba hypertensive mice by INUI, YOSUKE, MOCHIDA, HIDEKI, YAMAIRI, FUMIKO, OKADA, MIYOKO, ISHIDA, JUNJI, FUKAMIZU, AKIYOSHI, ARAKAWA, KENJI

“…Renal dysfunction is accelerated by various factors such as hypertension, aging and diabetes. Glomerular hyper-filtration, considered one of the major risk…”
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Identification of Novel Series of Potent and Selective Relaxin Family Peptide Receptor 1 (RXFP1) Agonists by Granberg, Kenneth L., Sakamaki, Shigeki, Fuchigami, Ryuichi, Niwa, Yasuki, Fujio, Masakazu, Kato, Harutoshi, Bergström, Fredrik, Larsson, Niklas, Persson, Mikael, Villar, Inmaculada C., Fujita, Takuya, Sugikawa, Emiko, Althage, Magnus, Yano, Naoko, Yokoyama, Yoshito, Kimura, Junpei, Lal, Mark, Mochida, Hideki

“…Relaxin H2 is a clinically relevant peptide agonist for relaxin family peptide receptor 1 (RXFP1), but a combination of this hormone’s short plasma half-life…”
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Discovery of Clinical Candidate AZD5462, a Selective Oral Allosteric RXFP1 Agonist for Treatment of Heart Failure by Granberg, Kenneth L., Sakamaki, Shigeki, Larsson, Niklas, Bergström, Fredrik, Fuchigami, Ryuichi, Niwa, Yasuki, Ryberg, Erik, Backmark, Anna, Kato, Harutoshi, Miyazaki, Shiki, Iguchi, Kaori, Sakamoto, Toshiaki, Persson, Mikael, Idei, Akiko, Prieto Garcia, Luna, Villar, Inmaculada C., Gradén, Henrik, Bergonzini, Giulia, Arvidsson, Torbjörn, Fujita, Takuya, Althage, Magnus, Ulander, Johan, Kimura, Junpei, Yoneda, Hikaru, Fjellström, Ola, Mochida, Hideki, Lal, Mark

“…Optimization of the highly potent and selective, yet metabolically unstable and poorly soluble hRXFP1 agonist AZ7976 led to the identification of the clinical…”
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mRNAs in urinary nano‑extracellular vesicles as potential biomarkers for non‑invasive kidney biopsy by Fujitaka, Keisuke, Murakami, Taku, Takeuchi, Masato, Kakimoto, Tetsuhiro, Mochida, Hideki, Arakawa, Kenji

“…Urinary nano-extracellular vesicles (NVs), including exosomes and microvesicles, are considered potential biomarkers for kidney diseases using liquid biopsies…”
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Avanafil, a highly selective phosphodiesterase type 5 inhibitor for erectile dysfunction, shows good safety profiles for retinal function and hemodynamics in anesthetized dogs by Mochida, Hideki, Yano, Koji, Inoue, Hirotaka, Yee, Shiyin, Noto, Tsunehisa, Kikkawa, Kohei

“…We evaluated the effects of the highly selective phosphodiesterase type 5 inhibitor avanafil on electroretinogram and hemodynamics in dogs, and compared the…”
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8-(3-Chloro-4-methoxybenzyl)-8H-pyrido[2,3-d]pyrimidin-7-one derivatives as potent and selective phosphodiesterase 5 inhibitors by Sakamoto, Toshiaki, Koga, Yuichi, Hikota, Masataka, Matsuki, Kenji, Mochida, Hideki, Kikkawa, Kohei, Fujishige, Kotomi, Kotera, Jun, Omori, Kenji, Morimoto, Hiroshi, Yamada, Koichiro

“…[Display omitted] A novel series of highly selective phosphodiesterase 5 (PDE5) inhibitors was found. 8H-Pyrido[2,3-d]pyrimidin-7-one derivatives bearing an…”
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Role of adenosine and P2 receptors in the penile tumescence in anesthetized dogs by Noto, Tsunehisa, Inoue, Hirotaka, Mochida, Hideki, Kikkawa, Kohei

“…We studied the role of adenosine and P2 receptors in the pelvic nerve stimulation-induced penile tumescence in anesthetized dogs. A local intracavernous…”
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Sildenafil and T-1032, phosphodiesterase type 5 inhibitors, showed a different vasorelaxant property in the isolated rat aorta by Mochida, Hideki, Inoue, Hirotaka, Takagi, Michino, Noto, Tsunehisa, Yano, Koji, Kikkawa, Kohei

“…The vasorelaxant effects of sildenafil and T-1032 [methyl-2-(4-aminophenyl)-1,2-dihydro-1-oxo-7-(2-pyridinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-3-isoquinoline…”
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T-0156, a novel phosphodiesterase type 5 inhibitor, and sildenafil have different pharmacological effects on penile tumescence and electroretinogram in dogs by Mochida, Hideki, Noto, Tsunehisa, Inoue, Hirotaka, Yano, Koji, Kikkawa, Kohei

“…T-0156 (2-(2-methylpyridin-4-yl)methyl-4-(3,4,5-trimethoxyphenyl)-8-(pyrimidin-2-yl)methoxy-1,2-dihydro-1-oxo-2,7-naphthyridine-3-carboxylic acid methyl ester…”
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The difference in relaxant property exists between two phosphodiesterase type 5 inhibitors, sildenafil and T-1032, in the isolated rat aorta by Hideki Mochida, Hirotaka Inoue, Tsunehisa Noto, Koji Yano, Kohei Kikkawa

“…Sildenafil and T-1032 are specific inhibitors of phosphodiesterase type 5 (PDE5), and their effects are similar in potency and selectivity. Sildenafil at…”
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Pharmacological profile of T-1032, a novel specific phosphodiesterase type 5 inhibitor, in isolated rat aorta and rabbit corpus cavernosum by Takagi, Michino, Mochida, Hideki, Noto, Tsunehisa, Yano, Koji, Inoue, Hirotaka, Ikeo, Tomihiro, Kikkawa, Kohei

“…This study was designed to examine the pharmacological properties of T-1032…”
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Enzymological and pharmacological profile of T-0156, a potent and selective phosphodiesterase type 5 inhibitor by Mochida, Hideki, Takagi, Michino, Inoue, Hirotaka, Noto, Tsunehisa, Yano, Koji, Fujishige, Kotomi, Sasaki, Takashi, Yuasa, Keizo, Kotera, Jun, Omori, Kenji, Kikkawa, Kohei

“…The enzymological and pharmacological properties of…”
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Pharmacological profile of T-0156, a newly synthetized phosphodiesterase type 5 inhibitor, in anesthetized dogs by Kohei Kikkawa, Tsunehisa Noto, Kouji Yano, Hirotaka Inoue, Hideki Mochida, Michino Takagi, Kotomi Pujishige, Jun Kotera, Takashi Sasaki, Kenji Omori

“…T-0156, a newly synthesized naphthyridinone derivative, showed a highly specific inhibition of phosphodiesterase type 5 (PDE5) in an enzyme assay (IC50 value…”
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Effects of high cell density on growth-associated monoclonal antibody production by hybridoma T0405 cells immobilized in macroporous cellulose carriers by Mochida, Hideki, Wang, Pi Chao, Nayve, Fr, Sato, Ryuji, Harigae, Minoru, Nomura, Nakao, Matsumura, Masatoshi

“…Relationship between monoclonal antibody (MAb) productivity and growth rate, and effects of high cell density on MAb production of hybridoma T0405 cells…”
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Effects of adenosine- and P2-receptor antagonists on the penile tumescence in the anesthetized dogs by Tsunehisa Noto, Hirotaka Inoue, Hideki Mochida, Kohei Kikkawa

“…We studied the effects of adenosine- and purinergic P2-receptor antagonists on the penile tumescence in the anesthetized dogs. Intracavernous adenosine (1 mM,…”
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