Search Results - "Hidefumi, Hiramatsu"

Current status of CAR-T cell therapy for pediatric hematologic malignancies by Hiramatsu, Hidefumi

“…Acute lymphoblastic leukemia (ALL) is the most common cancer in the pediatric population, and the long-term survival can reach 90%. However, approximately, 20%…”
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Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia by Orlando, Elena J., Han, Xia, Tribouley, Catherine, Wood, Patricia A., Leary, Rebecca J., Riester, Markus, Levine, John E., Qayed, Muna, Grupp, Stephan A., Boyer, Michael, De Moerloose, Barbara, Nemecek, Eneida R., Bittencourt, Henrique, Hiramatsu, Hidefumi, Buechner, Jochen, Davies, Stella M., Verneris, Michael R., Nguyen, Kevin, Brogdon, Jennifer L., Bitter, Hans, Morrissey, Michael, Pierog, Piotr, Pantano, Serafino, Engelman, Jeffrey A., Winckler, Wendy

“…We identified genetic mutations in CD19 and loss of heterozygosity at the time of CD19 – relapse to chimeric antigen receptor (CAR) therapy. The mutations are…”
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Attenuation of miR-126 Activity Expands HSC In Vivo without Exhaustion by Lechman, Eric R., Gentner, Bernhard, van Galen, Peter, Giustacchini, Alice, Saini, Massimo, Boccalatte, Francesco E., Hiramatsu, Hidefumi, Restuccia, Umberto, Bachi, Angela, Voisin, Veronique, Bader, Gary D., Dick, John E., Naldini, Luigi

“…Lifelong blood cell production is governed through the poorly understood integration of cell-intrinsic and -extrinsic control of hematopoietic stem cell (HSC)…”
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Adverse prognostic impact of KIT exon 17 mutations despite negative flow cytometric measurable residual disease in pediatric acute myeloid leukemia with RUNX1::RUNX1T1 by Kato, Shota, Tsujimoto, Shin-Ichi, Matsubayashi, Jun, Iwamoto, Shotaro, Hiramatsu, Hidefumi, Okuno, Yusuke, Kamitori, Tatsuya, Ohki, Kentaro, Deguchi, Takao, Kiyokawa, Nobutaka, Kato, Motohiro, Takita, Junko, Tanaka, Shiro, Adachi, Souichi, Tomizawa, Daisuke, Shiba, Norio

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Efficacy and safety of tisagenlecleucel in Japanese pediatric and young adult patients with relapsed/refractory B cell acute lymphoblastic leukemia by Hiramatsu, Hidefumi, Adachi, Souichi, Umeda, Katsutsugu, Kato, Itaru, Eldjerou, Lamis, Agostinho, Andrea Chassot, Natsume, Kazuto, Tokushige, Kota, Watanabe, Yoko, Grupp, Stephan A.

“…Tisagenlecleucel is an autologous T cell genetically modified ex vivo using a lentiviral vector encoding an anti-CD19 chimeric antigen receptor. Here, we…”
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Identification of hematopoietic stem cell-specific miRNAs enables gene therapy of globoid cell leukodystrophy by Gentner, Bernhard, Visigalli, Ilaria, Hiramatsu, Hidefumi, Lechman, Eric, Ungari, Silvia, Giustacchini, Alice, Schira, Giulia, Amendola, Mario, Quattrini, Angelo, Martino, Sabata, Orlacchio, Aldo, Dick, John E, Biffi, Alessandra, Naldini, Luigi

“…Globoid cell leukodystrophy (GLD; also known as Krabbe disease) is an invariably fatal lysosomal storage disorder caused by mutations in the…”
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Successful re‐administration of all‐trans retinoic acid after acute pancreatitis by Daifu, Tomoo, Umeda, Katsutsugu, Takahashi, Hiroyuki, Hiramatsu, Hidefumi, Kato, Itaru

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CD146 is a potential immunotarget for neuroblastoma by Obu, Satoshi, Umeda, Katsutsugu, Ueno, Hiroo, Sonoda, Mari, Tasaka, Keiji, Ogata, Hideto, Kouzuki, Kagehiro, Nodomi, Seishiro, Saida, Satoshi, Kato, Itaru, Hiramatsu, Hidefumi, Okamoto, Tatsuya, Ogawa, Eri, Okajima, Hideaki, Morita, Ken, Kamikubo, Yasuhiko, Kawaguchi, Koji, Watanabe, Kenichiro, Iwafuchi, Hideto, Yagyu, Shigeki, Iehara, Tomoko, Hosoi, Hajime, Nakahata, Tatsutoshi, Adachi, Souichi, Uemoto, Shinji, Heike, Toshio, Takita, Junko

“…Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to arise from neural crest‐derived immature cells. The prognosis of patients…”
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Temozolomide and etoposide combination for the treatment of relapsed osteosarcoma by Akazawa, Ryo, Umeda, Katsutsugu, Saida, Satoshi, Kato, Itaru, Hiramatsu, Hidefumi, Sakamoto, Akio, Arakawa, Yoshiki, Sumiyoshi, Shinji, Okamoto, Takeshi, Moritake, Hiroshi, Adachi, Souichi, Takita, Junko

“…The prognosis of patients with relapsed osteosarcoma is extremely poor and the optimal treatment remains to be identified. Here, we retrospectively analysed…”
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Ponatinib in pediatric patients with Philadelphia chromosome-positive leukemia: a retrospective survey of the Japan Children’s Cancer Group by Kodama, Yuichi, Sato, Atsushi, Kato, Keisuke, Sakaguchi, Hirotoshi, Kato, Motohiro, Kawasaki, Hirohide, Hiramatsu, Hidefumi, Kato, Itaru, Taga, Takashi, Shimada, Hiroyuki

“…Ponatinib is effective in adults with Philadelphia chromosome-positive (Ph+) leukemia, resistant or intolerant to second-generation tyrosine kinase inhibitors,…”
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Post‐transplant Lymphoproliferative Disorders After Liver Transplantation: A Retrospective Cohort Study Including 1954 Transplants by Tajima, Tetsuya, Hata, Koichiro, Haga, Hironori, Nishikori, Momoko, Umeda, Katsutsugu, Kusakabe, Jiro, Miyauchi, Hidetaka, Okamoto, Tatsuya, Ogawa, Eri, Sonoda, Mari, Hiramatsu, Hidefumi, Fujimoto, Masakazu, Okajima, Hideaki, Takita, Junko, Takaori‐Kondo, Akifumi, Uemoto, Shinji

“…Post‐transplant lymphoproliferative disorders (PTLDs) are life‐threatening neoplasms after organ transplantation. Because of their rarity and multiple grades…”
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Pluripotent stem cell model of Shwachman–Diamond syndrome reveals apoptotic predisposition of hemoangiogenic progenitors by Hamabata, Takayuki, Umeda, Katsutsugu, Kouzuki, Kagehiro, Tanaka, Takayuki, Daifu, Tomoo, Nodomi, Seishiro, Saida, Satoshi, Kato, Itaru, Baba, Shiro, Hiramatsu, Hidefumi, Osawa, Mitsujiro, Niwa, Akira, Saito, Megumu K., Kamikubo, Yasuhiko, Adachi, Souichi, Hashii, Yoshiko, Shimada, Akira, Watanabe, Hiroyoshi, Osafune, Kenji, Okita, Keisuke, Nakahata, Tatsutoshi, Watanabe, Kenichiro, Takita, Junko, Heike, Toshio

“…Shwachman–Diamond syndrome (SDS), an autosomal recessive disorder characterized by bone marrow failure, exocrine pancreatic insufficiency, and skeletal…”
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Influence of post-transplant mucosal-associated invariant T cell recovery on the development of acute graft-versus-host disease in allogeneic bone marrow transplantation by Kawaguchi, Koji, Umeda, Katsutsugu, Hiejima, Eitaro, Iwai, Atsushi, Mikami, Masamitsu, Nodomi, Seishiro, Saida, Satoshi, Kato, Itaru, Hiramatsu, Hidefumi, Yasumi, Takahiro, Nishikomori, Ryuta, Kondo, Tadakazu, Takaori-Kondo, Akifumi, Heike, Toshio, Adachi, Souichi

“…Mucosal-associated invariant T (MAIT) and invariant natural killer T (iNKT) cells are T cell subpopulations that possess innate-like properties. We examined…”
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Post-induction MRD by FCM and GATA1-PCR are significant prognostic factors for myeloid leukemia of Down syndrome by Taga, Takashi, Tanaka, Shiro, Hasegawa, Daisuke, Terui, Kiminori, Toki, Tsutomu, Iwamoto, Shotaro, Hiramatsu, Hidefumi, Miyamura, Takako, Hashii, Yoshiko, Moritake, Hiroshi, Nakayama, Hideki, Takahashi, Hiroyuki, Shimada, Akira, Taki, Tomohiko, Ito, Etsuro, Hama, Asahito, Ito, Masafumi, Koh, Katsuyoshi, Hasegawa, Daiichiro, Saito, Akiko M., Adachi, Souichi, Tomizawa, Daisuke

“…Myeloid leukemia of Down syndrome (ML-DS) is associated with good response to chemotherapy, resulting in favorable outcomes. However, no universal prognostic…”
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Outcome and growth of lobar graft after pediatric living-donor lobar lung transplantation by Tanaka, Satona, Nakajima, Daisuke, Sakamoto, Ryo, Oguma, Tsuyoshi, Kawaguchi, Atsushi, Ohsumi, Akihiro, Ohata, Keiji, Ueda, Satoshi, Yamagishi, Hiroya, Kayawake, Hidenao, Yutaka, Yojiro, Yamada, Yoshito, Hamaji, Masatsugu, Hamada, Satoshi, Tanizawa, Kiminobu, Handa, Tomohiro, Suga, Takenori, Baba, Shiro, Hiramatsu, Hidefumi, Ikeda, Tadashi, Date, Hiroshi

“…Living-donor lobar lung transplantation (LDLLT) remains a life-saving option for pediatric patients with respiratory failure. However, the long-term survival…”
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Author Correction: Pluripotent stem cell model of Shwachman–Diamond syndrome reveals apoptotic predisposition of hemoangiogenic progenitors by Hamabata, Takayuki, Umeda, Katsutsugu, Kouzuki, Kagehiro, Tanaka, Takayuki, Daifu, Tomoo, Nodomi, Seishiro, Saida, Satoshi, Kato, Itaru, Baba, Shiro, Hiramatsu, Hidefumi, Osawa, Mitsujiro, Niwa, Akira, Saito, Megumu K., Kamikubo, Yasuhiko, Adachi, Souichi, Hashii, Yoshiko, Shimada, Akira, Watanabe, Hiroyoshi, Osafune, Kenji, Okita, Keisuke, Nakahata, Tatsutoshi, Watanabe, Kenichiro, Takita, Junko, Heike, Toshio

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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A phase III clinical trial evaluating efficacy and safety of minimal residual disease-based risk stratification for children with acute myeloid leukemia, incorporating a randomized study of gemtuzumab ozogamicin in combination with post-induction chemotherapy for non-low-risk patients (JPLSG-AML-20) by Tomizawa, Daisuke, Tsujimoto, Shin-ichi, Tanaka, Shiro, Matsubayashi, Jun, Aoki, Takahiro, Iwamoto, Shotaro, Hasegawa, Daisuke, Nagai, Kozo, Nakashima, Kentaro, Kawaguchi, Koji, Deguchi, Takao, Kiyokawa, Nobutaka, Ohki, Kentaro, Hiramatsu, Hidefumi, Shiba, Norio, Terui, Kiminori, Saito, Akiko Moriya, Kato, Motohiro, Taga, Takashi, Koshinaga, Tsugumichi, Adachi, Souichi

“…The purpose of this study is to establish a treatment with appropriate intensity for children (<16 years old at diagnosis) with de novo acute myeloid leukemia…”
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PAX5 alterations in an infant case of KMT2A‐rearranged leukemia with lineage switch by Nakajima, Koji, Kubota, Hirohito, Kato, Itaru, Isobe, Kiyotaka, Ueno, Hiroo, Kozuki, Kagehiro, Tanaka, Kuniaki, Kawabata, Naoko, Mikami, Takashi, Tamefusa, Kosuke, Nishiuchi, Ritsuo, Saida, Satoshi, Umeda, Katsutsugu, Hiramatsu, Hidefumi, Adachi, Souichi, Takita, Junko

“…Lineage switch is a rare event at leukemic relapse. While mostly known to occur in KMT2A‐rearranged infant leukemia, the underlying mechanism is yet to be…”
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Correction to: Post-induction MRD by FCM and GATA1-PCR are significant prognostic factors for myeloid leukemia of Down syndrome by Taga, Takashi, Tanaka, Shiro, Hasegawa, Daisuke, Terui, Kiminori, Toki, Tsutomu, Iwamoto, Shotaro, Hiramatsu, Hidefumi, Miyamura, Takako, Hashii, Yoshiko, Moritake, Hiroshi, Nakayama, Hideki, Takahashi, Hiroyuki, Shimada, Akira, Taki, Tomohiko, Ito, Etsuro, Hama, Asahito, Ito, Masafumi, Koh, Katsuyoshi, Hasegawa, Daiichiro, Saito, Akiko M., Adachi, Souichi, Tomizawa, Daisuke

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Reduced-intensity conditioning is effective for hematopoietic stem cell transplantation in young pediatric patients with Diamond–Blackfan anemia by Koyamaishi, Shun, Kamio, Takuya, Kobayashi, Akie, Sato, Tomohiko, Kudo, Ko, Sasaki, Shinya, Kanezaki, Rika, Hasegawa, Daiichiro, Muramatsu, Hideki, Takahashi, Yoshiyuki, Sasahara, Yoji, Hiramatsu, Hidefumi, Kakuda, Harumi, Tanaka, Miyuki, Ishimura, Masataka, Nishi, Masanori, Ishiguro, Akira, Yabe, Hiromasa, Sarashina, Takeo, Yamamoto, Masaki, Yuza, Yuki, Hyakuna, Nobuyuki, Yoshida, Kenichi, Kanno, Hitoshi, Ohga, Shouichi, Ohara, Akira, Kojima, Seiji, Miyano, Satoru, Ogawa, Seishi, Toki, Tsutomu, Terui, Kiminori, Ito, Etsuro

“…Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative therapy for the hematologic manifestations of Diamond–Blackfan anemia (DBA)…”
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