Search Results - "Hide, Geoff"
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iNOS is essential to maintain a protective Th1/Th2 response and the production of cytokines/chemokines against Schistosoma japonicum infection in rats
Published in PLoS neglected tropical diseases (01-05-2022)“…Humans and a wide range of mammals are generally susceptible to Schistosoma infection, while some rodents such as Rattus rats and Microtus spp are not. We…”
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2
The Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments
Published in Nature communications (22-02-2023)“…Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells, in which intracellular multiplication occurs, yet the mechanisms…”
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3
Revealing the progression and pathologic features of intraperitoneal infection of Trichomonas vaginalis in mice via parasite α-actinin-based immunological detection
Published in BMC infectious diseases (17-10-2024)“…Trichomoniasis caused by Trichomonas vaginalis is the most prevalent nonviral sexually transmitted disease in women and has frequently damaged public health…”
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Mat Seroprevalence Infers Low Rates of Toxoplasma gondii in Domestic Pigs from Yucatan, Mexico
Published in The Journal of parasitology (01-10-2019)“…Toxoplasma gondii is a zoonotic parasite of worldwide distribution. The consumption of infected pork meat has been suggested to be an important source for…”
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5
Species identification and phylogenetic analysis of Leishmania isolated from patients, vectors and hares in the Xinjiang Autonomous Region, The People's Republic of China
Published in PLoS neglected tropical diseases (01-12-2021)“…Visceral leishmaniasis (VL) has been declared as one of the six major tropical diseases by the World Health Organization. This disease has been successfully…”
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Functional screening reveals Toxoplasma prenylated proteins required for endocytic trafficking and rhoptry protein sorting
Published in mBio (31-08-2023)“…In the apicomplexans, endocytosed cargos (e.g., hemoglobin) are trafficked to a specialized organelle for digestion. This follows a unique endocytotic process…”
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The transplant rejection response involves neutrophil and macrophage adhesion-mediated trogocytosis and is regulated by NFATc3
Published in Cell death & disease (19-01-2024)“…The anti-foreign tissue (transplant rejection) response, mediated by the immune system, has been the biggest obstacle to successful organ transplantation…”
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Review of " Parasites of medical and veterinary importance " by Dietmar Steverding
Published in Parasites & Vectors (09-09-2011)“…Herbert Utz VerlagEMPTYPubdate: 2011EMPTYPages: 246EMPTYNote: ISBN 978-3831640577 Author details1-Centre for Parasitology and Disease, School of Environment…”
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The Toxoplasma monocarboxylate transporters are involved in the metabolism within the apicoplast and are linked to parasite survival
Published in eLife (19-03-2024)“…The apicoplast is a four-membrane plastid found in the apicomplexans, which harbors biosynthesis and organelle housekeeping activities in the matrix. However,…”
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Further evidence from SSCP and ITS DNA sequencing support Trypanosoma evansi and Trypanosoma equiperdum as subspecies or even strains of Trypanosoma brucei
Published in Infection, genetics and evolution (01-07-2016)“…The subgenus Trypanozoon includes three species Trypanosoma brucei, Trypanosoma evansi and Trypanosoma equiperdum, which are morphologically identical and…”
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The Occurrence of Malignancy in Trypanosoma brucei brucei by Rapid Passage in Mice
Published in Frontiers in microbiology (11-01-2022)“…Pleomorphic are best known for their tightly controlled cell growth and developmental program, which ensures their transmissibility and host fitness between…”
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Transplantation of Gut Microbiota From High-Fat-Diet-Tolerant Cynomolgus Monkeys Alleviates Hyperlipidemia and Hepatic Steatosis in Rats
Published in Frontiers in microbiology (25-03-2022)“…Emerging evidence has been reported to support the involvement of the gut microbiota in the host's blood lipid and hyperlipidemia (HLP). However, there remains…”
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best practice for preparation of samples from FTA®cards for diagnosis of blood borne infections using African trypanosomes as a model system
Published in Parasites & vectors (07-05-2011)“…BACKGROUND: Diagnosis of blood borne infectious diseases relies primarily on the detection of the causative agent in the blood sample. Molecular techniques…”
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Development of a preclinical orthotopic xenograft model of ewing sarcoma and other human malignant bone disease using advanced in vivo imaging
Published in PloS one (07-01-2014)“…Ewing sarcoma and osteosarcoma represent the two most common primary bone tumours in childhood and adolescence, with bone metastases being the most adverse…”
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Differences in iNOS and arginase expression and activity in the macrophages of rats are responsible for the resistance against T. gondii infection
Published in PloS one (25-04-2012)“…Toxoplasma gondii infects humans and warm blooded animals causing devastating disease worldwide. It has long been a mystery as to why the peritoneal…”
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Circulating tumour DNA is a promising biomarker for risk stratification of central chondrosarcoma with IDH1/2 and GNAS mutations
Published in Molecular oncology (01-12-2021)“…Chondrosarcoma (CS) is a rare tumour type and the most common primary malignant bone cancer in adults. The prognosis, currently based on tumour grade, imaging…”
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Constraints to estimating the prevalence of trypanosome infections in East African zebu cattle
Published in Parasites & vectors (06-09-2010)“…BACKGROUND: In East Africa, animal trypanosomiasis is caused by many tsetse transmitted protozoan parasites including Trypanosoma vivax, T. congolense and…”
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Innate Resistance to Leishmania amazonensis Infection in Rat Is Dependent on NOS2
Published in Frontiers in microbiology (29-10-2021)“…Leishmania infection causes diverse clinical manifestations in humans. The disease outcome is complicated by the combination of many host and parasite factors…”
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Multiomics of parkinsonism cynomolgus monkeys highlights significance of metabolites in interaction between host and microbiota
Published in NPJ biofilms and microbiomes (26-07-2024)“…The gut microbiota has been demonstrated to play a significant role in the pathogenesis of Parkinson’s disease (PD). However, conflicting findings regarding…”
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PAG3 promotes the differentiation of bloodstream forms in Trypanosoma brucei and reveals the evolutionary relationship among the Trypanozoon trypanosomes
Published in Frontiers in cellular and infection microbiology (30-11-2022)“…Introduction Trypanosoma brucei, T. evansi and T. equiperdum are members of the subgenus Trypanozoon and are highly similar morphologically and genetically…”
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