Search Results - "Hidalgo Miranda, Alfredo"
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Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer‐based precipitation and size exclusion chromatography
Published in Journal of extracellular vesicles (01-04-2021)“…The molecular characterization of extracellular vesicles (EVs) has revealed a great heterogeneity in their composition at a cellular and tissue level. Current…”
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Expression of long non‐coding RNA ENSG00000226738 (LncKLHDC7B) is enriched in the immunomodulatory triple‐negative breast cancer subtype and its alteration promotes cell migration, invasion, and resistance to cell death
Published in Molecular oncology (01-04-2019)“…Triple negative breast cancer (TNBC) represents an aggressive phenotype with poor prognosis compared with ER, PR, and HER2‐positive tumors. TNBC is a…”
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Breast cancer proteomics reveals a positive correlation between glyoxalase 1 expression and high tumor grade
Published in International journal of oncology (01-08-2012)“…Breast cancer is the neoplasia with the highest incidence in women worldwide. Proteomics approaches have accelerated the discovery of diagnostic and prognostic…”
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Systems consequences of amplicon formation in human breast cancer
Published in Genome research (01-10-2014)“…Chromosomal structural variations play an important role in determining the transcriptional landscape of human breast cancers. To assess the nature of these…”
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Functional Integrity and Gene Expression Profiles of Human Cord Blood‐Derived Hematopoietic Stem and Progenitor Cells Generated In Vitro
Published in Stem cells translational medicine (01-08-2018)“…To date, different experimental strategies have been developed for the ex vivo expansion of human hematopoietic stem (HSCs) and progenitor (HPCs) cells. This…”
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Global gene expression profiles of hematopoietic stem and progenitor cells from patients with chronic myeloid leukemia: the effect of in vitro culture with or without imatinib
Published in Cancer medicine (Malden, MA) (01-12-2017)“…In this study, we determined the gene expression profiles of bone marrow‐derived cell fractions, obtained from normal subjects and Chronic Myeloid Leukemia…”
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miRNA biogenesis: Biological impact in the development of cancer
Published in Cancer biology & therapy (02-11-2014)“…microRNAs (miRNAs) are non coding RNAs with different biological functions and pathological implications. Given their role as post-transcriptional gene…”
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WNT signaling modulates PD-L1 expression in the stem cell compartment of triple-negative breast cancer
Published in Oncogene (01-05-2019)“…Triple-negative breast cancers (TNBCs) are characterized by a poor prognosis and lack of targeted treatments, and thus, new therapeutic strategies are urgently…”
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Recurrent and functional regulatory mutations in breast cancer
Published in Nature (London) (06-07-2017)“…Genomic analysis of tumours has led to the identification of hundreds of cancer genes on the basis of the presence of mutations in protein-coding regions. By…”
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10
Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing
Published in Proceedings of the National Academy of Sciences - PNAS (06-03-2012)“…To gain insight into the genomic basis of diffuse large B-cell lymphoma (DLBCL), we performed massively parallel whole-exome sequencing of 55 primary tumor…”
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Loss of function of miR-342-3p results in MCT1 over-expression and contributes to oncogenic metabolic reprogramming in triple negative breast cancer
Published in Scientific reports (16-08-2018)“…Triple-negative breast cancer (TNBC) is a heterogeneous and aggressive neoplasia lacking the expression of hormonal receptors and human epidermal growth factor…”
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12
Exosomal lncRNAs as regulators of breast cancer chemoresistance and metastasis and their potential use as biomarkers
Published in Frontiers in oncology (01-08-2024)“…Breast cancer is the most common cancer in women and the leading cause of female deaths by cancer in the world worldwide. Hence, understanding the molecular…”
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Mitochondrial Heteroplasmy Shifting as a Potential Biomarker of Cancer Progression
Published in International journal of molecular sciences (09-07-2021)“…Cancer is a serious health problem with a high mortality rate worldwide. Given the relevance of mitochondria in numerous physiological and pathological…”
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MicroRNAs transported by exosomes in body fluids as mediators of intercellular communication in cancer
Published in OncoTargets and therapy (01-01-2014)“…Cancer-cell communication is an important and complex process, achieved through a diversity of mechanisms that allows tumor cells to mold and influence their…”
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LINC00426 is a potential immune phenotype-related biomarker and an overall survival predictor in PAM50 luminal B breast cancer
Published in Frontiers in genetics (16-05-2023)“…Breast cancer (BRCA) represents the most frequent diagnosed malignancy in women worldwide. Despite treatment advances, BRCAs eventually develop resistance to…”
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Altered expression of circulating microRNA in plasma of patients with primary osteoarthritis and in silico analysis of their pathways
Published in PloS one (05-06-2014)“…To analyze a set of circulating microRNA (miRNA) in plasma from patients with primary Osteoarthritis (OA) and describe the biological significance of altered…”
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The current advances of lncRNAs in breast cancer immunobiology research
Published in Frontiers in immunology (05-06-2023)“…Breast cancer is the most frequently diagnosed malignancy and the leading cause of cancer-related death in women worldwide. Breast cancer development and…”
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The Human Papillomavirus (HPV) E1 protein regulates the expression of cellular genes involved in immune response
Published in Scientific reports (20-09-2019)“…The Human Papillomavirus (HPV) E1 protein is the only viral protein with enzymatic activity. The main known function of this protein is the regulation of the…”
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Analysis of genomic diversity in Mexican Mestizo populations to develop genomic medicine in Mexico
Published in Proceedings of the National Academy of Sciences - PNAS (26-05-2009)“…Mexico is developing the basis for genomic medicine to improve healthcare of its population. The extensive study of genetic diversity and linkage…”
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Salivary Extracellular Vesicles Separation: Analysis of Ultracentrifugation-Based Protocols
Published in Oral diseases (27-10-2024)“…The clinical potential of extracellular vesicles (EVs) is widely acknowledged, yet the standardization and reproducibility of its separation remain…”
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