Search Results - "Hidalgo, Bertha A"

A 6-CpG validated methylation risk score model for metabolic syndrome: The HyperGEN and GOLDN studies by Hidalgo, Bertha A, Minniefield, Bre, Patki, Amit, Tanner, Rikki, Bagheri, Minoo, Tiwari, Hemant K, Arnett, Donna K, Irvin, Marguerite Ryan

“…There has been great interest in genetic risk prediction using risk scores in recent years, however, the utility of scores developed in European populations…”
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Neighborhood Environment and Epigenetic Age: A Scoping Review by Jackson, Pamela, Kempf, Mirjam-Colette, Goodin, Burel R., A. Hidalgo, Bertha, Aroke, Edwin N.

“…Background: Interest in how the neighborhood environment impacts age-related health conditions has been increasing for decades. Epigenetic changes are…”
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Epigenome-wide association study of triglyceride postprandial responses to a high-fat dietary challenge[S] by Lai, Chao-Qiang, Wojczynski, Mary K., Parnell, Laurence D., Hidalgo, Bertha A., Irvin, Marguerite Ryan, Aslibekyan, Stella, Province, Michael A., Absher, Devin M., Arnett, Donna K., Ordovás, José M.

“…Postprandial lipemia (PPL), the increased plasma TG concentration after consuming a high-fat meal, is an independent risk factor for CVD. Individual responses…”
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A methylation risk score for chronic kidney disease: a HyperGEN study by Jones, Alana C., Patki, Amit, Srinivasasainagendra, Vinodh, Hidalgo, Bertha A., Tiwari, Hemant K., Limdi, Nita A., Armstrong, Nicole D., Chaudhary, Ninad S., Minniefield, Bré, Absher, Devin, Arnett, Donna K., Lange, Leslie A., Lange, Ethan M., Young, Bessie A., Diamantidis, Clarissa J., Rich, Stephen S., Mychaleckyj, Josyf C., Rotter, Jerome I., Taylor, Kent D., Kramer, Holly J., Tracy, Russell P., Durda, Peter, Kasela, Silva, Lappalinen, Tuuli, Liu, Yongmei, Johnson, W. Craig, Van Den Berg, David J., Franceschini, Nora, Liu, Simin, Mouton, Charles P., Bhatti, Parveen, Horvath, Steve, Whitsel, Eric A., Irvin, Marguerite R.

“…Chronic kidney disease (CKD) impacts about 1 in 7 adults in the United States, but African Americans (AAs) carry a disproportionately higher burden of disease…”
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Epigenetic Age Acceleration in Mothers and Offspring 4-10 Years after a Pregnancy Complicated by Gestational Diabetes and Obesity by Kanney, Nita, Patki, Amit, Chandler-Laney, Paula, Garvey, W Timothy, Hidalgo, Bertha A

“…A known association exists between exposure to gestational diabetes mellitus (GDM) and epigenetic age acceleration (EAA) in GDM-exposed offspring compared to…”
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Genetic Contributors of Incident Stroke in 10,700 African Americans With Hypertension: A Meta-Analysis From the Genetics of Hypertension Associated Treatments and Reasons for Geographic and Racial Differences in Stroke Studies by Armstrong, Nicole D, Srinivasasainagendra, Vinodh, Patki, Amit, Tanner, Rikki M, Hidalgo, Bertha A, Tiwari, Hemant K, Limdi, Nita A, Lange, Ethan M, Lange, Leslie A, Arnett, Donna K, Irvin, Marguerite R

“…African Americans (AAs) suffer a higher stroke burden due to hypertension. Identifying genetic contributors to stroke among AAs with hypertension is critical…”
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Obesity and Overweight: Probing Causes, Consequences, and Novel Therapeutic Approaches Through the American Heart Association's Strategically Focused Research Network by Clark, Jeanne M, Garvey, W Timothy, Niswender, Kevin D, Schmidt, Ann Marie, Ahima, Rexford S, Aleman, Jose O, Battarbee, Ashley N, Beckman, Joshua, Bennett, Wendy L, Brown, Nancy J, Chandler-Laney, Paula, Cox, Nancy, Goldberg, Ira J, Habegger, Kirk M, Harper, Lorie M, Hasty, Alyssa H, Hidalgo, Bertha A, Kim, Sangwon F, Locher, Julie L, Luther, James M, Maruthur, Nisa M, Miller, Edgar R, Sevick, Mary Ann, Wells, Quinn

“…As the worldwide prevalence of overweight and obesity continues to rise, so too does the urgency to fully understand mediating mechanisms, to discover new…”
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Mother‐child cardiometabolic health 4–10 years after pregnancy complicated by obesity with and without gestational diabetes by Martin, Samantha L., Zhang, Li, Callahan, Makenzie L., Bahorski, Jessica, Lewis, Cora E., Hidalgo, Bertha A., Durant, Nefertiti, Harper, Lorie M., Battarbee, Ashley N., Habegger, Kirk, Moore, Bethany A., Everett, Alysha, Aslibekyan, Stella, Sertie, Rogerio, Yi, Nengjun, Garvey, W. Timothy, Chandler‐Laney, Paula

“…Objective Obesity in pregnancy and gestational diabetes (GDM) increase cardiometabolic disease risk but are difficult to disentangle. This study aimed to test…”
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SMOC2 gene interacts with APOL1 in the development of end-stage kidney disease: A genome-wide association study by Chaudhary, Ninad S, Armstrong, Nicole D, Hidalgo, Bertha A, Gutiérrez, Orlando M, Hellwege, Jacklyn N, Limdi, Nita A, Reynolds, Richard J, Judd, Suzanne E, Nadkarni, Girish N, Lange, Leslie, Winkler, Cheryl A, Kopp, Jeffrey B, Arnett, Donna K, Tiwari, Hemant K, Irvin, Marguerite R

“…Some but not all African-Americans (AA) who carry nephropathy risk variants ( ) develop kidney failure (end-stage kidney disease, ESKD). To identify genetic…”
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Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity by Lai, Chao-Qiang, Smith, Caren E, Parnell, Laurence D, Lee, Yu-Chi, Corella, Dolores, Hopkins, Paul, Hidalgo, Bertha A, Aslibekyan, Stella, Province, Michael A, Absher, Devin, Arnett, Donna K, Tucker, Katherine L, Ordovas, Jose M

“…The putative functional variant −265T>C (rs5082) within the APOA2 promoter has shown consistent interactions with saturated fatty acid (SFA) intake to…”
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Epigenetic age acceleration mediates the relationship between neighborhood deprivation and pain severity in adults with or at risk for knee osteoarthritis pain by Jackson, Pamela, Spector, Antoinette L., Strath, Larissa J., Antoine, Lisa H., Li, Peng, Goodin, Burel R., Hidalgo, Bertha A., Kempf, Mirjam-Colette, Gonzalez, Cesar E., Jones, Alana C., Foster, Thomas C., Peterson, Jessica A., Quinn, Tammie, Huo, Zhiguang, Fillingim, Roger, Cruz-Almeida, Yenisel, Aroke, Edwin N.

“…An estimated 250 million people worldwide suffer from knee osteoarthritis (KOA), with older adults having greater risk. Like other age-related diseases,…”
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Impact of Rare and Common Genetic Variants on Diabetes Diagnosis by Hemoglobin A1c in Multi-Ancestry Cohorts: The Trans-Omics for Precision Medicine Program by Sarnowski, Chloé, Leong, Aaron, Raffield, Laura M., Wu, Peitao, de Vries, Paul S., DiCorpo, Daniel, Guo, Xiuqing, Xu, Huichun, Liu, Yongmei, Zheng, Xiuwen, Hu, Yao, Brody, Jennifer A., Goodarzi, Mark O., Hidalgo, Bertha A., Highland, Heather M., Jain, Deepti, Liu, Ching-Ti, Naik, Rakhi P., O’Connell, Jeffrey R., Perry, James A., Porneala, Bianca C., Selvin, Elizabeth, Wessel, Jennifer, Psaty, Bruce M., Curran, Joanne E., Peralta, Juan M., Blangero, John, Kooperberg, Charles, Mathias, Rasika, Johnson, Andrew D., Reiner, Alexander P., Mitchell, Braxton D., Cupples, L. Adrienne, Vasan, Ramachandran S., Correa, Adolfo, Morrison, Alanna C., Boerwinkle, Eric, Rotter, Jerome I., Rich, Stephen S., Manning, Alisa K., Dupuis, Josée, Meigs, James B.

“…Hemoglobin A1c (HbA1c) is widely used to diagnose diabetes and assess glycemic control in individuals with diabetes. However, nonglycemic determinants,…”
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APOL1 Risk Variants Associated with Serum Albumin in a Population-Based Cohort Study by Chaudhary, Ninad S, Tiwari, Hemant K, Hidalgo, Bertha A, Limdi, Nita A, Reynolds, Richard J, Cushman, Mary, Zakai, Neil A, Lange, Leslie, Judd, Suzanne E, Winkler, Cheryl A, Kopp, Jeffrey B, Gutiérrez, Orlando M, Irvin, Marguerite R

“…The association of apolipoprotein L1 (APOL1) nephropathy risk variants (APOL1), unique to African-ancestry (African-American [AA]) populations, with systemic…”
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Associations between SLC16A11 variants and diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) by Hidalgo, Bertha A., Sofer, Tamar, Qi, Qibin, Schneiderman, Neil, Chen, Y.-D. Ida, Kaplan, Robert C., Avilés-Santa, M. Larissa, North, Kari E., Arnett, Donna K., Szpiro, Adam, Cai, Jianwen, Yu, Bing, Boerwinkle, Eric, Papanicolaou, George, Laurie, Cathy C., Rotter, Jerome I., Stilp, Adrienne M.

“…Five sequence variants in SLC16A11 (rs117767867, rs13342692, rs13342232, rs75418188, and rs75493593), which occur in two non-reference haplotypes, were…”
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Genetic Contributors of Efficacy and Adverse Metabolic Effects of Chlorthalidone in African Americans from the Genetics of Hypertension Associated Treatments (GenHAT) Study by Armstrong, Nicole D, Srinivasasainagendra, Vinodh, Chekka, Lakshmi Manasa S, Nguyen, Nam H K, Nahid, Noor A, Jones, Alana C, Tanner, Rikki M, Hidalgo, Bertha A, Limdi, Nita A, Claas, Steven A, Gong, Yan, McDonough, Caitrin W, Cooper-DeHoff, Rhonda M, Johnson, Julie A, Tiwari, Hemant K, Arnett, Donna K, Irvin, Marguerite R

“…Hypertension is a leading risk factor for cardiovascular disease mortality. African Americans (AAs) have the highest prevalence of hypertension in the United…”
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Linkage and association analysis of circulating vitamin D and parathyroid hormone identifies novel loci in Alaska Native Yup'ik people by Aslibekyan, Stella, Vaughan, Laura K, Wiener, Howard W, Hidalgo, Bertha A, Lemas, Dominick J, O'Brien, Diane M, Hopkins, Scarlett E, Stanhope, Kimber L, Havel, Peter J, Thummel, Kenneth E, Boyer, Bert B, Tiwari, Hemant K

“…Vitamin D deficiency is a well-documented public health issue with both genetic and environmental determinants. Populations living at far northern latitudes…”
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Genome- and CD4+ T-cell methylome-wide association study of circulating trimethylamine-N-oxide in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) by Aslibekyan, Stella, Irvin, Marguerite R, Hidalgo, Bertha A, Perry, Rodney T, Jeyarajah, Elias J, Garcia, Erwin, Shalaurova, Irina, Hopkins, Paul N, Province, Michael A, Tiwari, Hemant K, Ordovas, Jose M, Absher, Devin M, Arnett, Donna K

“…Abstract Background Trimethylamine-N-oxide (TMAO), an atherogenic metabolite species, has emerged as a possible new risk factor for cardiovascular disease…”
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An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis by Liu, Jun, Carnero-Montoro, Elena, van Dongen, Jenny, Lent, Samantha, Nedeljkovic, Ivana, Ligthart, Symen, Tsai, Pei-Chien, Martin, Tiphaine C., Mandaviya, Pooja R., Jansen, Rick, Peters, Marjolein J., Duijts, Liesbeth, Jaddoe, Vincent W. V., Tiemeier, Henning, Felix, Janine F., Willemsen, Gonneke, de Geus, Eco J. C., Chu, Audrey Y., Levy, Daniel, Hwang, Shih-Jen, Bressler, Jan, Gondalia, Rahul, Salfati, Elias L., Herder, Christian, Hidalgo, Bertha A., Tanaka, Toshiko, Moore, Ann Zenobia, Lemaitre, Rozenn N., Jhun, Min A, Smith, Jennifer A., Sotoodehnia, Nona, Bandinelli, Stefania, Ferrucci, Luigi, Arnett, Donna K., Grallert, Harald, Assimes, Themistocles L., Hou, Lifang, Baccarelli, Andrea, Whitsel, Eric A., van Dijk, Ko Willems, Amin, Najaf, Uitterlinden, André G., Sijbrands, Eric J. G., Franco, Oscar H., Dehghan, Abbas, Spector, Tim D., Dupuis, Josée, Hivert, Marie-France, Rotter, Jerome I., Meigs, James B., Pankow, James S., van Meurs, Joyce B. J., Isaacs, Aaron, Boomsma, Dorret I., Bell, Jordana T., Demirkan, Ayşe, van Duijn, Cornelia M.

“…Despite existing reports on differential DNA methylation in type 2 diabetes (T2D) and obesity, our understanding of its functional relevance remains limited…”
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Abstract P128: The Epigenomic Signature of Life's Simple 7 by Gowda, Niranjan, Irvin, Marguerite R, Hidalgo, Bertha A, Tiwari, Hemant K, Absher, Devin M, Arnett, Donna K, Aslibekyan, Stella W

“…Abstract only Introduction: Life’s Simple 7 (LS7) comprises seven health factors and behaviors promoted by the American Heart Association to reduce…”
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Abstract P099: A Methylome- and Transcriptome-Wide Study of Dietary Fructose Intake in Humans by Aslibekyan, Stella, Do, Anh N, Irvin, Marguerite R, Hidalgo, Bertha A, Zhi, Degui, Tiwari, Hemant K, Absher, Devin M, Ordovas, Jose M, Arnett, Donna K

“…Abstract only Background: Animal model studies reported robust associations between fructose intake, a known determinant of metabolic health across species,…”
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