Search Results - "Hida, Yoko"

Cullin-4B E3 ubiquitin ligase mediates Apaf-1 ubiquitination to regulate caspase-9 activity by Ohta, Eri, Itoh, Masanori, Ueda, Masashi, Hida, Yoko, Wang, Miao-Xing, Hayakawa-Ogura, Miki, Li, Shimo, Nishida, Emika, Ohta, Kazunori, Tana, Islam, Saiful, Nakagawa, Kiyomi, Sunayama, Tomomi, Chen, Huayue, Hirata, So, Endo, Masashi, Ohno, Yoya, Nakagawa, Toshiyuki

“…Apoptotic protease-activating factor 1 (Apaf-1) is a component of apoptosome, which regulates caspase-9 activity. In addition to apoptosis, Apaf-1 plays…”
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Autophagy impairment stimulates PS1 expression and γ-secretase activity by Ohta, Kazunori, Mizuno, Akihito, Ueda, Masashi, Li, Shimo, Suzuki, Yoshihiro, Hida, Yoko, Hayakawa-Yano, Yoshika, Itoh, Masanori, Ohta, Eri, Kobori, Masuko, Nakagawa, Toshiyuki

“…γ-Secretase plays an important role in the development of Alzheimer disease (AD). γ-Secretase activity is enriched in autophagic vacuoles and it augments…”
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Polyglutamine expansion disturbs the endoplasmic reticulum formation, leading to caspase-7 activation through Bax by Ueda, Masashi, Li, Shimo, Itoh, Masanori, Hayakawa-Yano, Yoshika, Wang, Miao-xing, Hayakawa, Miki, Hasebe-Matsubara, Ryoko, Ohta, Kazunori, Ohta, Eri, Mizuno, Akihito, Hida, Yoko, Matsumoto, Munekazu, Chen, Huayue, Nakagawa, Toshiyuki

“…•ER morphology is disrupted in a mouse model of Huntington’s disease (HD).•Caspase-7 activation induced by polyglutamine is triggered by insertion of Bax into…”
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The expression and localization of Prune2 mRNA in the central nervous system by Li, Shimo, Itoh, Masanori, Ohta, Kazunori, Ueda, Masashi, Mizuno, Akihito, Ohta, Eri, Hida, Yoko, Wang, Miao-xing, Takeuchi, Kazunori, Nakagawa, Toshiyuki

“…► Cancer-related Prune2 mRNA is expressed in the brainstem and spinal cord. ► Prune2 mRNA is distributed in the motor neurons of cranial nerve and spinal cord…”
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Cayman Ataxia-Related Protein is a Presynapse-Specific Caspase-3 Substrate by Itoh, Masanori, Li, Shimo, Ohta, Kazunori, Yamada, Aiko, Hayakawa-Yano, Yoshika, Ueda, Masashi, Hida, Yoko, Suzuki, Yoshihiro, Ohta, Eri, Mizuno, Akihito, Banno, Yoshiko, Nakagawa, Toshiyuki

“…Caspase plays an important role in apoptosis and physiological processes such as synaptic plasticity. However, the caspase substrate at the synapse is still…”
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Inhibition of Small Maf Function in Pancreatic β-Cells Improves Glucose Tolerance Through the Enhancement of Insulin Gene Transcription and Insulin Secretion by Nomoto, Hiroshi, Kondo, Takuma, Miyoshi, Hideaki, Nakamura, Akinobu, Hida, Yoko, Yamashita, Ken-ichiro, Sharma, Arun J, Atsumi, Tatsuya

“…The large-Maf transcription factor v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MafA) has been found to be crucial for insulin transcription and…”
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Endoplasmic reticulum stress enhances γ-secretase activity by Ohta, Kazunori, Mizuno, Akihito, Li, Shimo, Itoh, Masanori, Ueda, Masashi, Ohta, Eri, Hida, Yoko, Wang, Miao-xing, Furoi, Manabu, Tsuzuki, Yukihiro, Sobajima, Mitsuaki, Bohmoto, Yoshimasa, Fukushima, Tatsuya, Kobori, Masuko, Inuzuka, Takashi, Nakagawa, Toshiyuki

“…► ER stress induces expression of presenilin-1. ► Presenilin-1 induction is dependent on ATF4. ► ER stress upregulates γ-secretase activity and increases Aβ…”
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CED-4 is an mRNA-binding protein that delivers ced-3 mRNA to ribosomes by Wang, Miao-xing, Masanori Itoh, Shimo Li, Yoko Hida, Kazunori Ohta, Miki Hayakawa, Emika Nishida, Masashi Ueda, Saiful Islam, Tana, Toshiyuki Nakagawa

“…Cell death abnormal (ced)-3 and ced-4 genes regulate apoptosis to maintain tissue homeostasis in Caenorhabditis elegans. Apoptosome formation and CED-4…”
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CED-4 is an mRNA-binding protein that delivers ced-3 mRNA to ribosomes by Wang, Miao-xing, Itoh, Masanori, Li, Shimo, Hida, Yoko, Ohta, Kazunori, Hayakawa, Miki, Nishida, Emika, Ueda, Masashi, Islam, Saiful, Tana, Nakagawa, Toshiyuki

“…Cell death abnormal (ced)-3 and ced-4 genes regulate apoptosis to maintain tissue homeostasis in Caenorhabditis elegans. Apoptosome formation and CED-4…”
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Olfaxin as a novel Prune2 isoform predominantly expressed in olfactory system by Li, Shimo, Hayakawa-Yano, Yoshika, Itoh, Masanori, Ueda, Masashi, Ohta, Kazunori, Suzuki, Yoshihiro, Mizuno, Akihito, Ohta, Eri, Hida, Yoko, Wang, Miao-xing, Nakagawa, Toshiyuki

“…Abstract Prune homolog 2 ( Drosophila ) ( PRUNE2 ) encodes a BCH motif-containing protein that shares homology with the Cayman ataxia-related protein Caytaxin…”
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Formation of p-Hydroxycocaine from Cocaine by Hepatic Microsomes of Animals and Its Pharmacological Effects in Mice by WATANABE, Kazuhito, HIDA, Yoko, MATSUNAGA, Tamihide, YAMAMOTO, Ikuo, YOSHIMURA, Hidetoshi

“…The hepatic microsomal metabolism of cocaine and the pharmacological effects of some metabolites were studied in experimental animals. Hepatic microsomes from…”
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An alternative spliced mouse presenilin-2 mRNA encodes a novel γ-secretase inhibitor by Suzuki, Yoshihiro, Ohta, Kazunori, Itoh, Masanori, Sakoh-Sumitomo, Yukari, Mitsuda, Teruhiko, Ueda, Masashi, Hayakawa-Yano, Yoshika, Li, Shimo, Hida, Yoko, Inuzuka, Takashi, Jung, Yong-Keun, Nakagawa, Toshiyuki

“…The γ-secretase, composed of presenilin-1 (PS1) or presenilin-2 (PS2), nicastrin (NCT), anterior pharynx-defective phenotype 1 (APH-1), and PEN-2, is critical…”
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Dysfunction of autophagy lead to activation of gamma-secretase through GCN2 by Ohta, Kazunori, Mizuno, Akihito, Ueda, Masashi, Li, Shimo, Suzuki, Yoshihiro, Hida, Yoko, Hayakawa-Yano, Yoshika, Itoh, Masanori, Ohta, Eri, Kobori, Masuko, Nakagawa, Toshiyuki

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Novel Iron Sequestering Agents:  Synthesis and Iron-Chelating Properties of Hexadentate Ligands Composed of 1-Hydroxy-2(1H)-pyrimidinone, ω-Amino Carboxylic Acid, and Tris(2-aminoethyl)amine by Ohkanda, Junko, Kamitani, Jun, Tokumitsu, Takeshi, Hida, Yoko, Konakahara, Takeo, Katoh, Akira

“…Novel heterocyclic hexadentate ligands (3HOPY n :  n = 5−7), in which three units of 1-hydroxy-2(1H)-pyrimidinone are linked to tris(2-aminoethyl)amine through…”
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