Search Results - "Hida, Hirotake"

Behavioral Phenotypes in Schizophrenic Animal Models With Multiple Combinations of Genetic and Environmental Factors by Hida, Hirotake, Mouri, Akihiro, Noda, Yukihiro

“…Schizophrenia is a multifactorial psychiatric disorder in which both genetic and environmental factors play a role. Genetic [e.g., Disrupted-in-schizophrenia 1…”
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Sensory evaluation of the bitterness of asenapine using D-sorbitol pretreatment: single-blind, placebo-controlled, crossover trial by Wada, Shuhei, Iwamoto, Kunihiro, Okumura, Hiroki, Hida, Hirotake, Hiraoka, Shuichi, Kamei, Aya, Mori, Daisuke, Yamada, Kiyofumi, Ozaki, Norio

“…Antipsychotics are essential in the acute treatment of and maintenance therapy for schizophrenia, but medication adherence and long-term treatment continuity…”
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Blonanserin ameliorates social deficit through dopamine-D3 receptor antagonism in mice administered phencyclidine as an animal model of schizophrenia by Takeuchi, Saori, Hida, Hirotake, Uchida, Mizuki, Naruse, Ryo, Yoshimi, Akira, Kitagaki, Shinji, Ozaki, Norio, Noda, Yukihiro

“…Blonanserin differs from other antipsychotic drugs, such as risperidone and olanzapine, and exhibits a higher affinity for dopamine-D2/3 receptors than for…”
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Effect of single-administration of D-sorbitol pretreatment on the bitterness and continued willingness to take asenapine: a randomized, single-blind, placebo-controlled, crossover trial by Wada, Shuhei, Iwamoto, Kunihiro, Okumura, Hiroki, Hida, Hirotake, Hiraoka, Shuichi, Kamei, Aya, Mori, Daisuke, Yamada, Kiyofumi, Ando, Masahiko, Ozaki, Norio, Ikeda, Masashi

“…Asenapine has unique orally-related side effects, such as a bitter taste induced by sublingual administration, which often results in discontinuation of the…”
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Early postnatal inhibition of GLAST causes abnormalities of psychobehaviors and neuronal morphology in adult mice by Uchida, Mizuki, Noda, Yukihiro, Hasegawa, Sho, Hida, Hirotake, Taniguchi, Masayuki, Mouri, Akihiro, Yoshimi, Akira, Nabeshima, Toshitaka, Yamada, Kiyofumi, Aida, Tomomi, Tanaka, Kohichi, Ozaki, Norio

“…The importance of glutamate transporters in learning, memory, and emotion remains poorly understood; hence, in the present study, we investigated whether…”
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Involvement of the histamine H4 receptor in clozapine-induced hematopoietic toxicity: Vulnerability under granulocytic differentiation of HL-60 cells by Goto, Aya, Mouri, Akihiro, Nagai, Tomoko, Yoshimi, Akira, Ukigai, Mako, Tsubai, Tomomi, Hida, Hirotake, Ozaki, Norio, Noda, Yukihiro

“…Clozapine is an effective antipsychotic for treatment-resistant schizophrenia, but can cause fatal hematopoietic toxicity as agranulocytosis. To elucidate the…”
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Functional roles of the glial glutamate transporter (GLAST) in emotional and cognitive abnormalities of mice after repeated phencyclidine administration by Uchida, Mizuki, Hida, Hirotake, Mori, Kentaro, Yoshimi, Akira, Kitagaki, Shinji, Yamada, Kiyofumi, Hiraoka, Yuichi, Aida, Tomomi, Tanaka, Kohichi, Ozaki, Norio, Noda, Yukihiro

“…•Repeated PCP administration induces emotional and cognitive impairments.•Repeated PCP administration is associated with increase of GLAST and S100 in the…”
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Blonanserin ameliorates phencyclidine-induced visual-recognition memory deficits: the complex mechanism of blonanserin action involving D₃-5-HT₂A and D₁-NMDA receptors in the mPFC by Hida, Hirotake, Mouri, Akihiro, Mori, Kentaro, Matsumoto, Yurie, Seki, Takeshi, Taniguchi, Masayuki, Yamada, Kiyofumi, Iwamoto, Kunihiro, Ozaki, Norio, Nabeshima, Toshitaka, Noda, Yukihiro

“…Blonanserin differs from currently used serotonin 5-HT₂A/dopamine-D₂ receptor antagonists in that it exhibits higher affinity for dopamine-D₂/₃ receptors than…”
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Juvenile social defeat stress exposure persistently impairs social behaviors and neurogenesis by Mouri, Akihiro, Ukai, Mayu, Uchida, Mizuki, Hasegawa, Sho, Taniguchi, Masayuki, Ito, Takahiro, Hida, Hirotake, Yoshimi, Akira, Yamada, Kiyofumi, Kunimoto, Shohko, Ozaki, Norio, Nabeshima, Toshitaka, Noda, Yukihiro

“…Adverse juvenile experiences, including physical abuse, often have negative health consequences later in life. We investigated the influence of social defeat…”
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1196. Influence of antibiotic use on the effectiveness and safety of immune checkpoint inhibitors in Japan by Minamishima, Takuya, Hida, Hirotake, Yamada, Kiyofumi

“…Abstract Background It has been reported that antibiotic use changes the gut microbiome and alters the outcome of treatment with immune checkpoint inhibitors…”
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Acute administration of ketamine attenuates the impairment of social behaviors induced by social defeat stress exposure as juveniles via activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by Hasegawa, Sho, Yoshimi, Akira, Mouri, Akihiro, Uchida, Yoji, Hida, Hirotake, Mishina, Masayoshi, Yamada, Kiyofumi, Ozaki, Norio, Nabeshima, Toshitaka, Noda, Yukihiro

“…The impairment of social behaviors induced by social defeat stress exposure as juveniles is resistant to some antidepressants and an antipsychotic, although…”
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Dysfunction of Serotonergic and Dopaminergic Neuronal Systems in the Antidepressant-Resistant Impairment of Social Behaviors Induced by Social Defeat Stress Exposure as Juveniles by Hasegawa, Sho, Miyake, Yuriko, Yoshimi, Akira, Mouri, Akihiro, Hida, Hirotake, Yamada, Kiyofumi, Ozaki, Norio, Nabeshima, Toshitaka, Noda, Yukihiro

“…Extensive studies have been performed on the role of monoaminergic neuronal systems in rodents exposed to social defeat stress as adults. In the present study,…”
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Erratum to “Functional roles of the glial glutamate transporter (GLAST) in emotional and cognitive abnormalities of mice after repeated phencyclidine administration” [European Neuropsychopharmacology (2019) 29, 914–924] by Uchida, Mizuki, Hida, Hirotake, Mori, Kentaro, Yoshimi, Akira, Kitagaki, Shinji, Yamada, Kiyofumi, Hiraoka, Yuichi, Aida, Tomomi, Tanaka, Kohichi, Ozaki, Norio, Noda, Yukihiro

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Involvement of the histamine H{sub 4} receptor in clozapine-induced hematopoietic toxicity: Vulnerability under granulocytic differentiation of HL-60 cells by Goto, Aya, Mouri, Akihiro, Nagai, Tomoko, Yoshimi, Akira, Ukigai, Mako, Tsubai, Tomomi, Hida, Hirotake, Ozaki, Norio, Noda, Yukihiro

“…Clozapine is an effective antipsychotic for treatment-resistant schizophrenia, but can cause fatal hematopoietic toxicity as agranulocytosis. To elucidate the…”
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PS112. Changes of serotonergic functions are mediated via metabolic control of serotonin transporter in stressed mice by Ito, Takahiro, Hida, Hirotake, Yamamoto, Fumiya, Hasegawa, Sho, Mouri, Akihiro, Ozaki, Norio, Noda, Yukihiro

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PM427. Histamine H4 receptor is involved in clozapine-induced hematopoietic toxicity: vulnerability under granulocytic differentiation of HL-60 cells by Goto, Aya, Mouri, Akihiro, Nagai, Tomoko, Ukigai, Mako, Tsubai, Tomomi, Hida, Hirotake, Ozaki, Norio, Noda, Yukihiro

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Combination of neonatal PolyI:C and adolescent phencyclidine treatments is required to induce behavioral abnormalities with overexpression of GLAST in adult mice by Hida, Hirotake, Mouri, Akihiro, Ando, Yu, Mori, Kentaro, Mamiya, Takayoshi, Iwamoto, Kunihiro, Ozaki, Norio, Yamada, Kiyofumi, Nabeshima, Toshitaka, Noda, Yukihiro

“…•Combination of neonatal PolyI:C with adolescent PCP treatments impaired behaviors.•The behavioral abnormalities were associated with glutamatergic…”
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PM346. Social defeat stress as juveniles impairs persistent social behaviors and neurogenesis by Noda, Yukihiro, Mouri, Akihiro, Yoshimi, Akira, Hasegawa, Sho, Ito, Takahiro, Hida, Hirotake, Yamada, Kiyofumi, Nabeshima, Toshitaka, Ozaki, Norio

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PS134. A strategy for treating in deficits of social behaviors induced by exposure to social defeat stress as juveniles by Hasegawa, Sho, Miyake, Yuriko, Yoshimi, Akira, Hida, Hirotake, Mouri, Akihiro, Yamada, Kiyofumi, Ozaki, Norio, Nabeshima, Toshitaka, Noda, Yukihiro

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児童向けくすり教育への薬学生の参画 by 小谷, 悠, 水野, 智博, 桑原, 宏貴, 安藤, 雄, 伊東, 和真, 新美, 友世, 大橋, 美月, 浅井, 玲名, 肥田, 裕丈, 平林, 彩, 室崎, 千尋, 加藤, 博史, 野田, 幸裕, 鍋島, 俊隆

“…「緒言」現在, セルフメディケーションの普及に伴って健康増進や疾病の予防及び治療を目的としてOTC薬を始め, 健康食品やサプリメントへの関心が高まっており, 特に高齢者ではくすりとともに健康食品の服用率が上昇している. 1)その一方で万全の注意を払っていても,…”
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