Search Results - "Hickson, Gilles R"

A back-up source of microtubules for the midbody during cytokinesis by Hickson, Gilles R X

“…During cytokinesis, microtubules become compacted into a dense midbody prior to abscission. Using genetic perturbations and imaging of C. elegans zygotes,…”
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Kinetochore-localized PP1–Sds22 couples chromosome segregation to polar relaxation by Rodrigues, Nelio T. L., Lekomtsev, Sergey, Jananji, Silvana, Kriston-Vizi, Janos, Hickson, Gilles R. X., Baum, Buzz

“…A study of division in proliferating animal cells points to the existence of a kinetochore-based signalling pathway, independent of furrow formation,…”
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Opposing actions of septins and Sticky on Anillin promote the transition from contractile to midbody ring by El Amine, Nour, Kechad, Amel, Jananji, Silvana, Hickson, Gilles R X

“…During cytokinesis, closure of the actomyosin contractile ring (CR) is coupled to the formation of a midbody ring (MR), through poorly understood mechanisms…”
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Interdomain allosteric regulation of Polo kinase by Aurora B and Map205 is required for cytokinesis by Kachaner, David, Pinson, Xavier, El Kadhi, Khaled Ben, Normandin, Karine, Talje, Lama, Lavoie, Hugo, Lépine, Guillaume, Carréno, Sébastien, Kwok, Benjamin H, Hickson, Gilles R, Archambault, Vincent

“…Drosophila melanogaster Polo and its human orthologue Polo-like kinase 1 fulfill essential roles during cell division. Members of the Polo-like kinase (Plk)…”
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Cell cycle regulation of Greatwall kinase nuclear localization facilitates mitotic progression by Wang, Peng, Galan, Jacob A, Normandin, Karine, Bonneil, Éric, Hickson, Gilles R, Roux, Philippe P, Thibault, Pierre, Archambault, Vincent

“…Cell division requires the coordination of critical protein kinases and phosphatases. Greatwall (Gwl) kinase activity inactivates PP2A-B55 at mitotic entry to…”
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Animal Cell Cytokinesis: The Rho-Dependent Actomyosin-Anilloseptin Contractile Ring as a Membrane Microdomain Gathering, Compressing, and Sorting Machine by Carim, Sabrya C., Kechad, Amel, Hickson, Gilles R. X.

“…Cytokinesis is the last step of cell division that partitions the cellular organelles and cytoplasm of one cell into two. In animal cells, cytokinesis requires…”
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Rho-dependent control of anillin behavior during cytokinesis by Hickson, Gilles R.X, O'Farrell, Patrick H

“…Anillin is a conserved protein required for cytokinesis but its molecular function is unclear. Anillin accumulation at the cleavage furrow is Rho guanine…”
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Rho-dependent control of the Citron kinase, Sticky, drives midbody ring maturation by El-Amine, Nour, Carim, Sabrya C, Wernike, Denise, Hickson, Gilles R X

“…Rho-dependent proteins control assembly of the cytokinetic contractile ring, yet it remains unclear how those proteins guide ring closure and how they promote…”
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IPIP27 Coordinates PtdIns(4,5)P 2 Homeostasis for Successful Cytokinesis by Carim, Sabrya C, Ben El Kadhi, Khaled, Yan, Guanhua, Sweeney, Sean T, Hickson, Gilles R, Carréno, Sébastien, Lowe, Martin

“…During cytokinesis, an actomyosin contractile ring drives the separation of the two daughter cells. A key molecule in this process is the inositol lipid…”
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IPIP27 Coordinates PtdIns(4,5)P2 Homeostasis for Successful Cytokinesis by Carim, Sabrya C., Ben El Kadhi, Khaled, Yan, Guanhua, Sweeney, Sean T., Hickson, Gilles R., Carréno, Sébastien, Lowe, Martin

“…During cytokinesis, an actomyosin contractile ring drives the separation of the two daughter cells. A key molecule in this process is the inositol lipid…”
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Anillin Acts as a Bifunctional Linker Coordinating Midbody Ring Biogenesis during Cytokinesis by Kechad, Amel, Jananji, Silvana, Ruella, Yvonne, Hickson, Gilles R.X.

“…Animal cell cytokinesis proceeds via constriction of an actomyosin-based contractile ring (CR) [1, 2]. Upon reaching a diameter of ∼1 μm [3], a midbody ring…”
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Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm by Chetaille, Philippe, Preuss, Christoph, Burkhard, Silja, Côté, Jean-Marc, Houde, Christine, Castilloux, Julie, Piché, Jessica, Gosset, Natacha, Leclerc, Séverine, Wünnemann, Florian, Thibeault, Maryse, Gagnon, Carmen, Galli, Antonella, Tuck, Elizabeth, Hickson, Gilles R, Amine, Nour El, Boufaied, Ines, Lemyre, Emmanuelle, de Santa Barbara, Pascal, Faure, Sandrine, Jonzon, Anders, Cameron, Michel, Dietz, Harry C, Gallo-McFarlane, Elena, Benson, D Woodrow, Moreau, Claudia, Labuda, Damian, Zhan, Shing H, Shen, Yaoqing, Jomphe, Michèle, Jones, Steven J M, Bakkers, Jeroen, Andelfinger, Gregor

“…Gregor Andelfinger and colleagues identify mutations in SGOL1 that cause a novel cohesinopathy characterized by chronic atrial and intestinal dysrhythmia,…”
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The Rho1 GTPase controls anillo-septin assembly to facilitate contractile ring closure during cytokinesis by Carim, Sabrya C., Hickson, Gilles R.X.

“…Animal cell cytokinesis requires activation of the GTPase RhoA (Rho1 in Drosophila), which assembles an F-actin- and myosin II-dependent contractile ring (CR)…”
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Multimodal and Polymorphic Interactions between Anillin and Actin: Their Implications for Cytokinesis by Jananji, Silvana, Risi, Cristina, Lindamulage, Indeewari K.S., Picard, Louis-Philippe, Van Sciver, Robert, Laflamme, Guillaume, Albaghjati, Abe, Hickson, Gilles R.X., Kwok, Benjamin H., Galkin, Vitold E.

“…Cytokinesis of animal cells requires the assembly of a contractile ring, which promotes daughter cell splitting. Anillin is a conserved scaffold protein…”
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Terminal Cytokinesis Events Uncovered after an RNAi Screen by Echard, Arnaud, Hickson, Gilles R.X., Foley, Edan, O'Farrell, Patrick H.

“…Much of our understanding of animal cell cytokinesis centers on the regulation of the equatorial acto-myosin contractile ring that drives the rapid ingression…”
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CLIC5: a novel ETV6 target gene in childhood acute lymphoblastic leukemia by Neveu, Benjamin, Spinella, Jean-François, Richer, Chantal, Lagacé, Karine, Cassart, Pauline, Lajoie, Mathieu, Jananji, Silvana, Drouin, Simon, Healy, Jasmine, Hickson, Gilles R X, Sinnett, Daniel

“…The most common rearrangement in childhood precursor B-cell acute lymphoblastic leukemia is the t(12;21)(p13;q22) translocation resulting in the ETV6-AML1…”
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Anillin: a pivotal organizer of the cytokinetic machinery by Hickson, Gilles R X, O'Farrell, Patrick H

“…Cytokinesis is a dynamic and plastic process involving the co-ordinated regulation of many components. Accordingly, many proteins, including the putative…”
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Rab11-FIP3 and FIP4 interact with Arf6 and the Exocyst to control membrane traffic in cytokinesis by Fielding, Andrew B, Schonteich, Eric, Matheson, Johanne, Wilson, Gayle, Yu, Xinzi, Hickson, Gilles RX, Srivastava, Sweta, Baldwin, Stephen A, Prekeris, Rytis, Gould, Gwyn W

“…The dual Rab11/Arf binding proteins, family of Rab11‐interacting proteins FIP3 and FIP4 function in the delivery of recycling endosomes to the cleavage furrow…”
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Binucleine 2, an Isoform-Specific Inhibitor of Drosophila Aurora B Kinase, Provides Insights into the Mechanism of Cytokinesis by Smurnyy, Yegor, Toms, Angela V, Hickson, Gilles R, Eck, Michael J, Eggert, Ulrike S

“…Aurora kinases are key regulators of cell division and important targets for cancer therapy. We report that Binucleine 2 is a highly isoform-specific inhibitor…”
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Cyclin B Destruction Triggers Changes in Kinetochore Behavior Essential for Successful Anaphase by Parry, Devin H., Hickson, Gilles R.X., O'Farrell, Patrick H.

“…Successful mitosis requires that anaphase chromosomes sustain a commitment to move to their assigned spindle poles. This requires stable spindle attachment of…”
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