Search Results - "Hicks, Sarah M"

Novel scientific approaches and future research directions in understanding ITP by Hicks, Sarah M., Coupland, Lucy A., Jahangiri, Anila, Choi, Philip Y., Gardiner, Elizabeth E.

“…Diagnosis of immune thrombocytopenia (ITP) and prediction of response to therapy remain significant and constant challenges in hematology. In patients who…”
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Tissue inhibitors of metalloproteinases (TIMPs) modulate platelet ADAM10 activity by Lee, Christine Shu Mei, Kaur, Amandeep, Montague, Samantha J., Hicks, Sarah M., Andrews, Robert K., Gardiner, Elizabeth E.

“…Platelet-specific collagen receptor glycoprotein (GP)VI is stable on the surface of circulating platelets but undergoes ectodomain cleavage on activated…”
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The molecular basis of immune-based platelet disorders by Hicks, Sarah M, Lee, Christine S M, Ali, Sidra A, Choi, Philip Y, Gardiner, Elizabeth E

“…Platelets have a predominant role in haemostasis, the maintenance of blood volume and emerging roles as innate immune cells, in wound healing and in…”
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Salt and water balance after sweat loss: A study of Bikram yoga by Alrefai, Hasan, Mathis, Shannon L., Hicks, Sarah M., Pivovarova, Aleksandra I., MacGregor, Gordon G.

“…Bikram yoga is practiced in a room heated to 105°F with 40% humidity for 90 min. During the class a large volume of water and electrolytes are lost in the…”
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Free Reelin’ Along the Platelet Surface by Hicks, Sarah M., Gardiner, Elizabeth E.

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Metabolic Detoxification Determines Species Differences in Coumarin-Induced Hepatotoxicity by Vassallo, Jeffrey D., Hicks, Sarah M., Daston, George P., Lehman-McKeeman, Lois D.

“…Hepatotoxicity of coumarin is attributed to metabolic activation to an epoxide intermediate, coumarin 3,4-epoxide (CE). However, whereas rats are most…”
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Phosphoproteomic Analysis of Platelets in Severe Obesity Uncovers Platelet Reactivity and Signaling Pathways Alterations by Barrachina, María N., Hermida-Nogueira, Lidia, Moran, Luis A., Casas, Vanessa, Hicks, Sarah M., Sueiro, Aurelio M., Di, Ying, Andrews, Robert K., Watson, Steve P., Gardiner, Elizabeth E., Abian, Joaquin, Carrascal, Montserrat, Pardo, María, García, Ángel

“…OBJECTIVE:Obesity is associated with a proinflammatory and prothrombotic state that supports atherosclerosis progression. The goal of this study was to gain…”
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Platelets mediate the clearance of senescent red blood cells by forming prophagocytic platelet-cell complexes by Ningtyas, Dian C., Leitner, Florentina, Sohail, Huma, Thong, Yee Lin, Hicks, Sarah M., Ali, Sidra, Drew, Megan, Javed, Kiran, Lee, Jiwon, Kenangalem, Enny, Poespoprodjo, Jeanne R., Anstey, Nicholas M., Rug, Melanie, Choi, Philip Y.-I., Kho, Steven, Gardiner, Elizabeth E., McMorran, Brendan J.

“…•Senescent RBCs are bound to platelets, forming P-RBC complexes that are selectively consumed by erythrophagocytes.•A sufficient supply of platelets is…”
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Fibrin exposure triggers αIIbβ3‐independent platelet aggregate formation, ADAM10 activity and glycoprotein VI shedding in a charge‐dependent manner by Montague, Samantha J., Hicks, Sarah M., Lee, Christine S‐M., Coupland, Lucy A., Parish, Christopher R., Lee, Woei M., Andrews, Robert K., Gardiner, Elizabeth E.

“…Background Collagen and fibrin engagement and activation of glycoprotein (GP) VI induces proteolytic cleavage of the GPVI ectodomain generating shed soluble…”
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Soluble glycoprotein VI predicts abdominal aortic aneurysm growth rate and is a novel therapeutic target by Benson, Tyler W., Pike, Mindy M., Spuzzillo, Anthony, Hicks, Sarah M., Ali, Sidra, Pham, Michael, Mix, Doran S., Brunner, Seth I., Wadding-Lee, Caris, Conrad, Kelsey A., Russell, Hannah M., Jennings, Courtney, Coughlin, Taylor M., Aggarwal, Anu, Lyden, Sean, Mani, Kevin, Björck, Martin, Wanhainen, Anders, Bhandari, Rohan, Lipworth-Elliot, Loren, Robinson-Cohen, Cassianne, Caputo, Francis J., Shim, Sharon, Quesada, Odayme, Tourdot, Benjamin, Edwards, Todd L., Tranter, Michael, Gardiner, Elizabeth E., Mackman, Nigel, Cameron, Scott J., Owens, A. Phillip

“…•sGPVI, a platelet-derived blood biomarker, is predictive of AAAs, with high specificity in distinguishing patients with rapidly growing AAA.•Blockade of GPVI…”
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A Dual-Antigen Enzyme-Linked Immunosorbent Assay Allows the Assessment of Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Seroprevalence in a Low-Transmission Setting by Hicks, Sarah M, Pohl, Kai, Neeman, Teresa, McNamara, Hayley A, Parsons, Kate M, He, Jin-shu, Ali, Sidra A, Nazir, Samina, Rowntree, Louise C, Nguyen, Thi H O, Kedzierska, Katherine, Doolan, Denise L, Vinuesa, Carola G, Cook, Matthew C, Coatsworth, Nicholas, Myles, Paul S, Kurth, Florian, Sander, Leif E, Mann, Graham J, Gruen, Russell L, George, Amee J, Gardiner, Elizabeth E, Cockburn, Ian A

“…Abstract Estimates of seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies have been hampered by inadequate assay…”
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Calcium loss in sweat does not stimulate PTH release: A study of Bikram hot yoga by Mathis, Shannon L., Pivovarova, Aleksandra I., Hicks, Sarah M., Alrefai, Hasan, MacGregor, Gordon G.

“…•A large amount of sweat is lost during 90 min of Bikram hot yoga which concentrates the extracellular fluid and blood.•Serum ionized calcium increased after…”
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Response to COVID‐19 vaccination in patients on cancer therapy: Analysis in a SARS‐CoV‐2‐naïve population by Cavic, George, Almonte, Andrew A., Hicks, Sarah M., Neeman, Teresa, Wang, Jo‐Wai, Brew, Sue, Choi, Philip Y., Cockburn, Ian, Gardiner, Elizabeth E., Yip, Desmond, Fahrer, Aude M., Kanjanapan, Yada

“…Background Cancer patients have increased morbidity and mortality from COVID‐19, but may respond poorly to vaccination. The Evaluation of COVID‐19 Vaccination…”
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Patients with Waldenström macroglobulinemia have impaired platelet and coagulation function by Brysland, Simone A., Talaulikar, Dipti, Hicks, Sarah M., Hearn, James I., Ali, Sidra A., Maqbool, Muhammad Gohar, Mokoonlall, Mridula, Bhoopalan, Vijay, Kaur, Amandeep, Thong, Yee Lin, Andrews, Robert K., Whisstock, James C., Crispin, Philip J., Gardiner, Elizabeth E.

“…•Slower thrombin generation and subdued enhancement by platelets were detected in WM samples.•WM-derived IgM impaired HD platelet spreading and aggregation,…”
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Immunohistochemical analysis of Clara cell secretory protein expression in a transgenic model of mouse lung carcinogenesis by Hicks, Sarah M., Vassallo, Jeffrey D., Dieter, Matthew Z., Lewis, Cindy L., Whiteley, Laurence O., Fix, Andrew S., Lehman-McKeeman, Lois D.

“…Immunohistochemical methods have been widely used to determine the histogenesis of spontaneous and chemically-induced mouse lung tumors. Typically, antigens…”
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A novel flow cytometry procoagulant assay for diagnosis of vaccine-induced immune thrombotic thrombocytopenia by Lee, Christine S.M., Liang, Hai Po Helena, Connor, David E., Dey, Agnibesh, Tohidi-Esfahani, Ibrahim, Campbell, Heather, Whittaker, Shane, Capraro, David, Favaloro, Emmanuel J., Donikian, Dea, Kondo, Mayuko, Hicks, Sarah M., Choi, Philip Y.-I., Gardiner, Elizabeth E., Clarke, Lisa Joanne, Tran, Huyen, Passam, Freda H., Brighton, Timothy Andrew, Chen, Vivien M.

“…Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a severe prothrombotic complication of adenoviral vaccines, including the ChAdOx1 nCoV-19…”
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Roles for Epoxidation and Detoxification of Coumarin in Determining Species Differences in Clara Cell Toxicity by Vassallo, Jeffrey D., Hicks, Sarah M., Born, Stephanie L., Daston, George P.

“…Coumarin-induced mouse Clara cell toxicity is thought to result from the local formation of coumarin 3,4-epoxide (CE). However, this toxicity is not observed…”
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Diethanolamine Induces Hepatic Choline Deficiency in Mice by Lehman-McKeeman, Lois D., Gamsky, Elizabeth A., Hicks, Sarah M., Vassallo, Jeffrey D., Mar, Mei-Heng, Zeisel, Steven H.

“…The purpose of the present experiments was to test the hypothesis that diethanolamine (DEA), an alkanolamine shown to be hepatocarcinogenic in mice, induces…”
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Platelets Bind Senescent Red Blood Cells and Mediate Their Clearance from the Circulation by McMorran, Brendan J., Ningtyas, Dian C, Leitner, Florentina, Javed, Kiran, Sawbridge, Megan, Hicks, Sarah M, Thong, Yee Lin, Lee, Jiwon, Rug, Melanie, Choi, Philip Y., Coupland, Lucy, Gardiner, Elizabeth E.

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Platelets mediate the clearance of senescent red blood cells by forming pro-phagocytic platelet-cell complexes by Ningtyas, Dian Citra, Leitner, Florentina, Sohail, Huma, Thong, Yee Lin, Hicks, Sarah M, Ali, Sidra Asad, Drew, Megan E, Javed, Kiran, Lee, Jiwon, Kenangalem, Enny, Poespoprodjo, Jeanne Rini, Anstey, Nicholas Mark, Rug, Melanie, Choi, Philip Y, Kho, Steven, Gardiner, Elizabeth E, McMorran, Brendan J

“…In humans approximately 0.1-0.3% of circulating red blood cells (RBC) are present as platelet-RBC (P-RBC) complexes, and 1-2% in mice. Excessive P-RBC…”
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