Search Results - "Hicks, Geoffrey G."

ALS-associated FUS mutations result in compromised FUS alternative splicing and autoregulation by Zhou, Yueqin, Liu, Songyan, Liu, Guodong, Oztürk, Arzu, Hicks, Geoffrey G

“…The gene encoding a DNA/RNA binding protein FUS/TLS is frequently mutated in amyotrophic lateral sclerosis (ALS). Mutations commonly affect its…”
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The RNA Binding Protein TLS Is Translocated to Dendritic Spines by mGluR5 Activation and Regulates Spine Morphology by Fujii, Ritsuko, Okabe, Shigeo, Urushido, Tomoe, Inoue, Kiyoshi, Yoshimura, Atsushi, Tachibana, Taro, Nishikawa, Toru, Hicks, Geoffrey G., Takumi, Toru

“…Neuronal dendrites, together with dendritic spines, exhibit enormously diverse structure [1]. Selective targeting and local translation of mRNAs in dendritic…”
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MicroRNA-200b regulates distal airway development by maintaining epithelial integrity by Khoshgoo, Naghmeh, Visser, Robin, Falk, Landon, Day, Chelsea A., Ameis, Dustin, Iwasiow, Barbara M., Zhu, Fuqin, Öztürk, Arzu, Basu, Sujata, Pind, Molly, Fresnosa, Agnes, Jackson, Mike, Siragam, Vinaya Kumar, Stelmack, Gerald, Hicks, Geoffrey G., Halayko, Andrew J., Keijzer, Richard

“…miR-200b plays a role in epithelial-to-mesenchymal transition (EMT) in cancer. We recently reported abnormal expression of miR-200b in the context of human…”
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The emerging functions of the p53-miRNA network in stem cell biology by Lin, Chao-Po, Choi, Yong Jin, Hicks, Geoffrey G., He, Lin

“…The p53 pathway plays an essential role in tumor suppression, regulating multiple cellular processes coordinately to maintain genome integrity in both somatic…”
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FUS/TLS deficiency causes behavioral and pathological abnormalities distinct from amyotrophic lateral sclerosis by Kino, Yoshihiro, Washizu, Chika, Kurosawa, Masaru, Yamada, Mizuki, Miyazaki, Haruko, Akagi, Takumi, Hashikawa, Tsutomu, Doi, Hiroshi, Takumi, Toru, Hicks, Geoffrey G, Hattori, Nobutaka, Shimogori, Tomomi, Nukina, Nobuyuki

“…FUS/TLS is an RNA-binding protein whose genetic mutations or pathological inclusions are associated with neurological diseases including amyotrophic lateral…”
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A novel, ataxic mouse model of ataxia telangiectasia caused by a clinically relevant nonsense mutation by Perez, Harvey, Abdallah, May F, Chavira, Jose I, Norris, Angelina S, Egeland, Martin T, Vo, Karen L, Buechsenschuetz, Callan L, Sanghez, Valentina, Kim, Jeannie L, Pind, Molly, Nakamura, Kotoka, Hicks, Geoffrey G, Gatti, Richard A, Madrenas, Joaquin, Iacovino, Michelina, McKinnon, Peter J, Mathews, Paul J

“…Ataxia Telangiectasia (A-T) and Ataxia with Ocular Apraxia Type 1 (AOA1) are devastating neurological disorders caused by null mutations in the genome…”
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Risk and Resilience Variants in the Retinoic Acid Metabolic and Developmental Pathways Associated with Risk of FASD Outcomes by McKay, Leo, Petrelli, Berardino, Pind, Molly, Reynolds, James N, Wintle, Richard F, Chudley, Albert E, Drögemöller, Britt, Fainsod, Abraham, Scherer, Stephen W, Hanlon-Dearman, Ana, Hicks, Geoffrey G

“…Fetal Alcohol Spectrum Disorder (FASD) is a common neurodevelopmental disorder that affects an estimated 2-5% of North Americans. FASD is induced by prenatal…”
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FUS/TLS acts as an aggregation-dependent modifier of polyglutamine disease model mice by Kino, Yoshihiro, Washizu, Chika, Kurosawa, Masaru, Yamada, Mizuki, Doi, Hiroshi, Takumi, Toru, Adachi, Hiroaki, Katsuno, Masahisa, Sobue, Gen, Hicks, Geoffrey G., Hattori, Nobutaka, Shimogori, Tomomi, Nukina, Nobuyuki

“…FUS/TLS is an RNA/DNA-binding protein associated with neurodegenerative diseases including amyotrophic lateral sclerosis and frontotemporal lobar degeneration…”
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Regulation of the cellular DNA double-strand break response by Cann, Kendra L, Hicks, Geoffrey G

“…DNA double-strand breaks occur frequently in cycling cells, and are also induced by exogenous sources, including ionizing radiation. Cells have developed…”
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Effects of prenatal alcohol exposure (PAE): insights into FASD using mouse models of PAE by Petrelli, Berardino, Weinberg, Joanne, Hicks, Geoffrey G

“…The potential impact of prenatal alcohol exposure (PAE) varies considerably among exposed individuals, with some displaying serious alcohol-related effects and…”
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Genomic Analysis of Localized High-Risk Prostate Cancer Circulating Tumor Cells at the Single-Cell Level by Rangel-Pozzo, Aline, Liu, Songyan, Wajnberg, Gabriel, Wang, Xuemei, Ouellette, Rodney J, Hicks, Geoffrey G, Drachenberg, Darrel, Mai, Sabine

“…Accurate risk classification of men with localized high-risk prostate cancer directly affects treatment management decisions and patient outcomes. A wide range…”
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A generalizable pre-clinical research approach for orphan disease therapy by Beaulieu, Chandree L, Samuels, Mark E, Ekins, Sean, McMaster, Christopher R, Edwards, Aled M, Krainer, Adrian R, Hicks, Geoffrey G, Frey, Brendan J, Boycott, Kym M, Mackenzie, Alex E

“…With the advent of next-generation DNA sequencing, the pace of inherited orphan disease gene identification has increased dramatically, a situation that will…”
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Insights into retinoic acid deficiency and the induction of craniofacial malformations and microcephaly in fetal alcohol spectrum disorder by Petrelli, Berardino, Bendelac, Liat, Hicks, Geoffrey G., Fainsod, Abraham

“…Summary Fetal Alcohol Spectrum Disorder (FASD) is a set of neurodevelopmental malformations caused by maternal consumption of alcohol during pregnancy. FASD…”
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ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS by López-Erauskin, Jone, Tadokoro, Takahiro, Baughn, Michael W., Myers, Brian, McAlonis-Downes, Melissa, Chillon-Marinas, Carlos, Asiaban, Joshua N., Artates, Jonathan, Bui, Anh T., Vetto, Anne P., Lee, Sandra K., Le, Ai Vy, Sun, Ying, Jambeau, Mélanie, Boubaker, Jihane, Swing, Deborah, Qiu, Jinsong, Hicks, Geoffrey G., Ouyang, Zhengyu, Fu, Xiang-Dong, Tessarollo, Lino, Ling, Shuo-Chien, Parone, Philippe A., Shaw, Christopher E., Marsala, Martin, Lagier-Tourenne, Clotilde, Cleveland, Don W., Da Cruz, Sandrine

“…Through the generation of humanized FUS mice expressing full-length human FUS, we identify that when expressed at near endogenous murine FUS levels, both…”
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miR-34 miRNAs provide a barrier for somatic cell reprogramming by He, Lin, Choi, Yong Jin, Lin, Chao-Po, Ho, Jaclyn J, He, Xingyue, Okada, Nobuhiro, Bu, Pengcheng, Zhong, Yingchao, Kim, Sang Yong, Bennett, Margaux J, Chen, Caifu, Ozturk, Arzu, Hicks, Geoffrey G, Hannon, Greg J

“…Somatic reprogramming induced by defined transcription factors is a low-efficiency process that is enhanced by p53 deficiency. So far, p21 is the only p53…”
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Identification and characterization of Dlc1 isoforms in the mouse and study of the biological function of a single gene trapped isoform by Sabbir, Mohammad G, Wigle, Nichola, Loewen, Shauna, Gu, Yuan, Buse, Cordula, Hicks, Geoffrey G, Mowat, Michael R A

“…The Dlc1 (deleted in liver cancer 1) tumour suppressor gene codes for a RhoGTPase activating protein that is found inactivated in many tumour types. Several…”
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The High-Mobility-Group Box Protein SSRP1/T160 Is Essential for Cell Viability in Day 3.5 Mouse Embryos by Cao, Shang, Bendall, Heather, Hicks, Geoffrey G., Nashabi, Abudi, Sakano, Hitoshi, Shinkai, Yoichi, Gariglio, Marisa, Oltz, Eugene M., Ruley, H. Earl

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Absence of an Immediate G1/S Checkpoint in Primary MEFs Following γ-irradiation Identifies a Novel Checkpoint Switch by Cann, Kendra L., Hicks, Geoffrey G.

“…DNA double-strand breaks caused by ionizing radiation have been shown to induce G1/S,intra-S-phase, and G2/M cell-cycle checkpoints. However, analysis of the…”
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The Canadian Rare Diseases Models and Mechanisms (RDMM) Network: Connecting Understudied Genes to Model Organisms by Boycott, Kym M., Campeau, Philippe M., Howley, Heather E., Pavlidis, Paul, Rogic, Sanja, Oriel, Christine, Berman, Jason N., Hamilton, Robert M., Hicks, Geoffrey G., Lipshitz, Howard D., Masson, Jean-Yves, Shoubridge, Eric. A., Junker, Anne, Leroux, Michel R., McMaster, Christopher R., Michaud, Jaques L., Turvey, Stuart E., Dyment, David, Innes, A. Micheil, van Karnebeek, Clara D., Lehman, Anna, Cohn, Ronald D., MacDonald, Ian M., Rachubinski, Richard A., Frosk, Patrick, Vandersteen, Anthony, Wozniak, Richard W., Pena, Izabella A., Wen, Xiao-Yan, Lacaze-Masmonteil, Thierry, Rankin, Catharine, Hieter, Philip

“…Advances in genomics have transformed our ability to identify the genetic causes of rare diseases (RDs), yet we have a limited understanding of the mechanistic…”
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Genome-Wide Transcriptome Landscape of Embryonic Brain-Derived Neural Stem Cells Exposed to Alcohol with Strain-Specific Cross-Examination in BL6 and CD1 Mice by Xu, Wayne, Liyanage, Vichithra R. B., MacAulay, Aaron, Levy, Romina D., Curtis, Kyle, Olson, Carl O., Zachariah, Robby M., Amiri, Shayan, Buist, Marjorie, Hicks, Geoffrey G., Davie, James R., Rastegar, Mojgan

“…We have previously reported the deregulatory impact of ethanol on global DNA methylation of brain-derived neural stem cells (NSC). Here, we conducted a…”
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