Search Results - "Hicks, Caroline A"

Neurotrophic actions of the novel AMPA receptor potentiator, LY404187, in rodent models of Parkinson's disease by O'Neill, Michael J, Murray, Tracey K, Whalley, Katherine, Ward, Mark A, Hicks, Caroline A, Woodhouse, Sandra, Osborne, David J, Skolnick, Phil

“…Recent developments in the molecular biology and pharmacology of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors has led to the…”
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In vivo study to assess dosage of allogeneic pig retinal progenitor cells: Long‐term survival, engraftment, differentiation and safety by Abud, Murilo Batista, Baranov, Petr, Patel, Sara, Hicks, Caroline A., Isaac, David Leonardo Cruvinel, Louzada, Ricardo Noguera, Dromel, Pierre, Singh, Deepti, Sinden, John, Ávila, Marcos P., Young, Michael

“…Despite notable efforts and significant therapeutical advances, age‐related macular degeneration remains the single most common reason for vision loss. Retinal…”
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Dopamine D2 receptor agonists protect against ischaemia-induced hippocampal neurodegeneration in global cerebral ischaemia by O'NEILL, M. J, HICKS, C. A, WARD, M. A, CARDWELL, G. P, REYMANN, J.-M, ALLAIN, H, BENTUE-FERRER, D

“…To characterise the role played by dopamine receptors in ischaemic brain damage, we have evaluated the effects of pergolide, bromocriptine and lisuride…”
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The neuronal nitric oxide synthase inhibitor, TRIM, as a neuroprotective agent: effects in models of cerebral ischaemia using histological and magnetic resonance imaging techniques by Haga, Kristin K, Gregory, Lloyd J, Hicks, Caroline A, Ward, Mark A, Beech, John S, Bath, Phillip W, Williams, Steven C.R, O'Neill, Michael J

“…Most neuroprotective compounds that appear promising in the pre-clinical phase of testing are subsequently dismissed as relatively ineffective when entered…”
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An AMPA receptor potentiator modulates hippocampal expression of BDNF: an in vivo study by Mackowiak, Marzena, O’Neill, Michael J, Hicks, Caroline A, Bleakman, David, Skolnick, Phil

“…AMPA receptor activation has been demonstrated to increase the neuronal expression of brain derived neurotrophic factor (BDNF). In the present study, we…”
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LY503430, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor potentiator with functional, neuroprotective and neurotrophic effects in rodent models of Parkinson's disease by Murray, Tracey K, Whalley, Katherine, Robinson, Christine S, Ward, Mark A, Hicks, Caroline A, Lodge, David, Vandergriff, Jim L, Baumbarger, Polly, Siuda, Edward, Gates, Mary, Ogden, Ann M, Skolnick, Phil, Zimmerman, Dennis M, Nisenbaum, Eric S, Bleakman, David, O'Neill, Michael J

“…Glutamate is the major excitatory transmitter in the brain. Recent developments in the molecular biology and pharmacology of the…”
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NMDA receptor antagonism, but not AMPA receptor antagonism attenuates induced ischaemic tolerance in the gerbil hippocampus by Bond, Ann, Lodge, David, Hicks, Caroline A, Ward, Mark A, O'Neill, Michael J

“…Recent studies have shown that a brief `pre-conditioning' ischaemic insult reduces the hippocampal cell death caused by a subsequent more severe test insult…”
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Decahydroisoquinolines: novel competitive AMPA/kainate antagonists with neuroprotective effects in global cerebral ischaemia by O'Neill, Michael J, Bond, Ann, Ornstein, Paul L, Ward, Mark A, Hicks, Caroline A, Hoo, Ken, Bleakman, David, Lodge, David

“…In the present studies, we have evaluated the activity of a series of glutamate receptor antagonists from the decahydroisoquinoline group of compounds both in…”
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Neuroprotective effects of a systemically active Group II metabotropic glutamate receptor agonist LY354740 in a gerbil model of global ischaemia by Bond, Ann, OʼNeill, Michael J, Hicks, Caroline A, Monn, James A, Lodge, David

“…THE neuroprotective effects of a novel Group II metabotropic glutamate receptor (mGluR) agonist, LY354740, have been evaluated in a gerbil model of global…”
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LY377770, a novel iGlu5 kainate receptor antagonist with neuroprotective effects in global and focal cerebral ischaemia by O'Neill, Michael J, Bogaert, Liesbeth, Hicks, Caroline A, Bond, Ann, Ward, Mark A, Ebinger, Guy, Ornstein, Paul L, Michotte, Yvette, Lodge, David

“…We have evaluated the neuroprotective effects of the decahydroisoquinoline LY377770, a novel iGlu5 kainate receptor antagonist, in two models of cerebral…”
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Effects of 5-hydroxytryptamine2 receptor antagonism on the behavioral activation and immediate early gene expression induced by dizocilpine by O'Neill, M F, Hicks, C A, Shaw, G, Parameswaran, T, Cardwell, G P, O'Neill, M J

“…The noncompetitive N-methyl-D-aspartate (NMDA) antagonists dizocilpine and phencyclidine cause behavioral changes in animals that can be blocked by…”
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Stereoselective effects of 2,3-benzodiazepines in vivo : Electrophysiology and neuroprotection studies by LODGE, D, BOND, A, O'NEILL, M. J, HICKS, C. A, JONES, M. G

“…The stereoselectivity and potency of 3N-substituted 2,3-benzodiazepines were examined in vivo against excitation of spinal neurones induced by electrophoretic…”
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Ascorbic acid is neuroprotective against global ischaemia in striatum but not hippocampus: histological and voltammetric data by Stamford, Jonathan A, Isaac, Dina, Hicks, Caroline A, Ward, Mark A, Osborne, David J, O'Neill, Michael J

“…Following reports that ascorbic acid (AA) blocks NMDA receptors, we examined its possible neuroprotective properties in vivo (gerbil bilateral carotid artery…”
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Synergistic neuroprotective effects by combining an NMDA or AMPA receptor antagonist with nitric oxide synthase inhibitors in global cerebral ischaemia by Hicks, Caroline A, Ward, Mark A, Swettenham, Jennifer B, O'Neill, Michael J

“…We have investigated the neuroprotective effects of combining an NMDA or AMPA receptor antagonist with a nitric oxide synthase (NOS) inhibitor in the gerbil…”
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Evaluation of glycine site antagonists of the NMDA receptor in global cerebral ischaemia by Hicks, Caroline A., Ward, Mark A., Ragumoorthy, Nella, Ambler, Samantha J., Dell, Colin P., Dobson, David, O'Neill, Michael J.

“…In the present studies we have investigated the effects of a range of glycine site antagonists of the N-methyl- d-aspartate (NMDA) receptor in the gerbil model…”
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Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanism of action in vivo by Bond, A, Jones, N M, Hicks, C A, Whiffin, G M, Ward, M A, O'Neill, M F, Kingston, A E, Monn, J A, Ornstein, P L, Schoepp, D D, Lodge, D, O'Neill, M J

“…The mechanisms underlying the neuroprotective effects of the group II metabotropic glutamate receptor (mGluR) agonist LY379268 were investigated in a gerbil…”
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LY379268, a potent and selective Group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal, cerebral ischaemia by Bond, Ann, Ragumoorthy, Nella, Monn, James A., Hicks, Caroline A., Ward, Mark A., Lodge, David, O'Neill, Michael J.

“…The neuroprotective effects of a selective Group II metabotropic glutamate receptor (mGluR) agonist, LY379268, have been evaluated against global and focal…”
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Dopamine D 2 receptor agonists protect against ischaemia-induced hippocampal neurodegeneration in global cerebral ischaemia by O'Neill, Michael J, Hicks, Caroline A, Ward, Mark A, Cardwell, Geraldine P, Reymann, Jean-Michel, Allain, Hervé, Bentué-Ferrer, Daniele

“…To characterise the role played by dopamine receptors in ischaemic brain damage, we have evaluated the effects of pergolide, bromocriptine and lisuride…”
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ARL 17477, a selective nitric oxide synthase inhibitor, with neuroprotective effects in animal models of global and focal cerebral ischaemia by O’Neill, Michael J., Murray, Tracey K., McCarty, Deborah R., Hicks, Caroline A., Dell, Colin P., Patrick, Kelly E., Ward, Mark A., Osborne, David J., Wiernicki, Todd R., Roman, Carlos R., Lodge, David, Fleisch, Jerome H., Singh, JaiPal

“…In the present studies, we have evaluated the effects of N-[4-(2-{[(3-Chlorophenyl)methyl]amino}ethyl)phenyl]-2-thiophenecarboximidamide dihydrochloride (ARL…”
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Neuroprotective effects of the neuronal Ca 2+ channel blockers, LY042826 and LY393615 in vivo by Hicks, Caroline A, Ward, Mark A, O'Neill, Michael J

“…In the present studies, we have examined the effects of two new Ca 2+ channel blockers, LY042826 ( N-{2-[(2-methylphenyl)(phenyl)methoxy]ethyl}-1-butanamine…”
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