Search Results - "Hickey, Raymond D."

Concise Review: Liver Regenerative Medicine: From Hepatocyte Transplantation to Bioartificial Livers and Bioengineered Grafts by Nicolas, Clara T., Hickey, Raymond D., Chen, Harvey S., Mao, Shennen A., Lopera Higuita, Manuela, Wang, Yujia, Nyberg, Scott L.

“…Donor organ shortage is the main limitation to liver transplantation as a treatment for end‐stage liver disease and acute liver failure. Liver regenerative…”
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The ploidy conveyor of mature hepatocytes as a source of genetic variation by Duncan, Andrew W, Taylor, Matthew H, Hickey, Raymond D, Hanlon Newell, Amy E, Lenzi, Michelle L, Olson, Susan B, Finegold, Milton J, Grompe, Markus

“…Mononucleated and binucleated polyploid hepatocytes (4n, 8n, 16n and higher) are found in all mammalian species, but the functional significance of this…”
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An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses by Schreiber, Claire A, Sakuma, Toshie, Izumiya, Yoshihiro, Holditch, Sara J, Hickey, Raymond D, Bressin, Robert K, Basu, Upamanyu, Koide, Kazunori, Asokan, Aravind, Ikeda, Yasuhiro

“…Adeno-associated viruses (AAV) have evolved to exploit the dynamic reorganization of host cell machinery during co-infection by adenoviruses and other helper…”
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Pivotal preclinical trial of the spheroid reservoir bioartificial liver by Glorioso, Jaime M, Mao, Shennen A, Rodysill, Brian, Mounajjed, Taufic, Kremers, Walter K, Elgilani, Faysal, Hickey, Raymond D, Haugaa, Hakon, Rose, Christopher F, Amiot, Bruce, Nyberg, Scott L

“…Graphical abstract…”
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In vivo lentiviral vector gene therapy to cure hereditary tyrosinemia type 1 and prevent development of precancerous and cancerous lesions by Nicolas, Clara T., VanLith, Caitlin J., Hickey, Raymond D., Du, Zeji, Hillin, Lori G., Guthman, Rebekah M., Cao, William J., Haugo, Benjamin, Lillegard, Annika, Roy, Diya, Bhagwate, Aditya, O’Brien, Daniel, Kocher, Jean-Pierre, Kaiser, Robert A., Russell, Stephen J., Lillegard, Joseph B.

“…Conventional therapy for hereditary tyrosinemia type-1 (HT1) with 2-(2-nitro-4-trifluoromethylbenzoyl)−1,3-cyclohexanedione (NTBC) delays and in some cases…”
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Hepatocyte spheroids as an alternative to single cells for transplantation after ex vivo gene therapy in mice and pig models by Nicolas, Clara T., Hickey, Raymond D., Allen, Kari L., Du, Zeji, Guthman, Rebekah M., Kaiser, Robert A., Amiot, Bruce, Bansal, Aditya, Pandey, Mukesh K., Suksanpaisan, Lukkana, DeGrado, Timothy R, Nyberg, Scott L., Lillegard, Joseph B.

“…Autologous hepatocyte transplantation after ex vivo gene therapy is an alternative to liver transplantation for metabolic liver disease. Here we evaluate ex…”
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Development of a porcine model of phenylketonuria with a humanized R408W mutation for gene editing by Kaiser, Robert A, Carlson, Daniel F, Allen, Kari L, Webster, Dennis A, VanLith, Caitlin J, Nicolas, Clara T, Hillin, Lori G, Yu, Yue, Kaiser, Catherine W, Wahoff, William R, Hickey, Raymond D, Watson, Adrienne L, Winn, Shelley R, Thöny, Beat, Kern, Douglas R, Harding, Cary O, Lillegard, Joseph B

“…Phenylketonuria (PKU) is a metabolic disorder whereby phenylalanine metabolism is deficient due to allelic variations in the gene for phenylalanine hydroxylase…”
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Ploidy reductions in murine fusion-derived hepatocytes by Duncan, Andrew W, Hickey, Raymond D, Paulk, Nicole K, Culberson, Andrew J, Olson, Susan B, Finegold, Milton J, Grompe, Markus

“…We previously showed that fusion between hepatocytes lacking a crucial liver enzyme, fumarylacetoacetate hydrolase (FAH), and wild-type blood cells resulted in…”
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Autologous Gene and Cell Therapy Provides Safe and Long-Term Curative Therapy in A Large Pig Model of Hereditary Tyrosinemia Type 1 by Hickey, Raymond D., Nicolas, Clara T., Allen, Kari, Mao, Shennen, Elgilani, Faysal, Glorioso, Jaime, Amiot, Bruce, VanLith, Caitlin, Guthman, Rebekah, Du, Zeji, Chen, Harvey, Harding, Cary O., Kaiser, Robert A., Nyberg, Scott L., Lillegard, Joseph B.

“…Orthotopic liver transplantation remains the only curative therapy for inborn errors of metabolism. Given the tremendous success for primary immunodeficiencies…”
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Effect of amine content and chemistry on long‐term, three‐dimensional hepatocyte spheroid culture atop aminated elastin‐like polypeptide coatings by Weeks, C. Andrew, Aden, Bethany, Zhang, Junlin, Singh, Anisha, Hickey, Raymond D., Kilbey, S. Michael, Nyberg, Scott L., Janorkar, Amol V.

“…Culture conditions that induce hepatic spheroidal aggregates sustain liver cells with metabolism that mimics in vivo hepatocytes. Here we present an array of…”
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Fumarylacetoacetate hydrolase deficient pigs are a novel large animal model of metabolic liver disease by Hickey, Raymond D., Mao, Shennen A., Glorioso, Jaime, Lillegard, Joseph B., Fisher, James E., Amiot, Bruce, Rinaldo, Piero, Harding, Cary O., Marler, Ronald, Finegold, Milton J., Grompe, Markus, Nyberg, Scott L.

“…Hereditary tyrosinemia type I (HT1) is caused by deficiency in fumarylacetoacetate hydrolase (FAH), an enzyme that catalyzes the last step of tyrosine…”
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Ex Vivo Cell Therapy by Ectopic Hepatocyte Transplantation Treats the Porcine Tyrosinemia Model of Acute Liver Failure by Nicolas, Clara T., Kaiser, Robert A., Hickey, Raymond D., Allen, Kari L., Du, Zeji, VanLith, Caitlin J., Guthman, Rebekah M., Amiot, Bruce, Suksanpaisan, Lukkana, Han, Bing, Francipane, Maria Giovanna, Cheikhi, Amin, Jiang, Huailei, Bansal, Aditya, Pandey, Mukesh K., Garg, Ishan, Lowe, Val, Bhagwate, Aditya, O’Brien, Daniel, Kocher, Jean-Pierre A., DeGrado, Timothy R., Nyberg, Scott L., Lagasse, Eric, Lillegard, Joseph B.

“…The effectiveness of cell-based therapies to treat liver failure is often limited by the diseased liver environment. Here, we provide preclinical proof of…”
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Glycosylation of PrPC Determines Timing of Neuroinvasion and Targeting in the Brain following Transmissible Spongiform Encephalopathy Infection by a Peripheral Route by CANCELLOTTI, Enrico, BRADFORD, Barry M, TUZI, Nadia L, HICKEY, Raymond D, BROWN, Debbie, BROWN, Karen L, BARRON, Rona M, KISIELEWSKI, Dorothy, PICCARDO, Pedro, MANSON, Jean C

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Suspension culture of hepatocyte-derived reporter cells in presence of albumin to form stable three-dimensional spheroids by Weeks, C. Andrew, Newman, Kristen, Turner, Paul A., Rodysill, Brian, Hickey, Raymond D., Nyberg, Scott L., Janorkar, Amol V.

“…Several studies in the past have formed 3‐dimensional (3D) spheroids of primary hepatocytes in suspension culture. Unfortunately, primary hepatocytes in a…”
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Ectopic expansion of engineered human liver tissue seeds using mature cell populations by Hickey, Raymond D., Naugler, Willscott E.

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In vivo partial cellular reprogramming enhances liver plasticity and regeneration by Hishida, Tomoaki, Yamamoto, Mako, Hishida-Nozaki, Yuriko, Shao, Changwei, Huang, Ling, Wang, Chao, Shojima, Kensaku, Xue, Yuan, Hang, Yuqing, Shokhirev, Maxim, Memczak, Sebastian, Sahu, Sanjeeb Kumar, Hatanaka, Fumiyuki, Ros, Ruben Rabadan, Maxwell, Matthew B., Chavez, Jasmine, Shao, Yanjiao, Liao, Hsin-Kai, Martinez-Redondo, Paloma, Guillen-Guillen, Isabel, Hernandez-Benitez, Reyna, Esteban, Concepcion Rodriguez, Qu, Jing, Holmes, Michael C., Yi, Fei, Hickey, Raymond D., Garcia, Pedro Guillen, Delicado, Estrella Nuñez, Castells, Antoni, Campistol, Josep M., Yu, Yang, Hargreaves, Diana C., Asai, Akihiro, Reddy, Pradeep, Liu, Guang-Hui, Izpisua Belmonte, Juan Carlos

“…Mammals have limited regenerative capacity, whereas some vertebrates, like fish and salamanders, are able to regenerate their organs efficiently. The…”
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Curative ex vivo liver-directed gene therapy in a pig model of hereditary tyrosinemia type 1 by Hickey, Raymond D, Mao, Shennen A, Glorioso, Jaime, Elgilani, Faysal, Amiot, Bruce, Chen, Harvey, Rinaldo, Piero, Marler, Ronald, Jiang, Huailei, DeGrado, Timothy R, Suksanpaisan, Lukkana, O'Connor, Michael K, Freeman, Brittany L, Ibrahim, Samar H, Peng, Kah Whye, Harding, Cary O, Ho, Chak-Sum, Grompe, Markus, Ikeda, Yasuhiro, Lillegard, Joseph B, Russell, Stephen J, Nyberg, Scott L

“…We tested the hypothesis that ex vivo hepatocyte gene therapy can correct the metabolic disorder in fumarylacetoacetate hydrolase-deficient (Fah(-/-)) pigs, a…”
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Efficient production of Fah‐null heterozygote pigs by chimeric adeno‐associated virus‐mediated gene knockout and somatic cell nuclear transfer by Hickey, Raymond D., Lillegard, Joseph B., Fisher, James E., McKenzie, Travis J., Hofherr, Sean E., Finegold, Milton J., Nyberg, Scott L., Grompe, Markus

“…Hereditary tyrosinemia type I (HT1) results in hepatic failure, cirrhosis, and hepatocellular carcinoma (HCC) early in childhood and is caused by a deficiency…”
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Chronic Phenotype Characterization of a Large-Animal Model of Hereditary Tyrosinemia Type 1 by Elgilani, Faysal, Mao, Shennen A, Glorioso, Jaime M, Yin, Meng, Iankov, Ianko D, Singh, Anisha, Amiot, Bruce, Rinaldo, Piero, Marler, Ronald J, Ehman, Richard L, Grompe, Markus, Lillegard, Joseph B, Hickey, Raymond D, Nyberg, Scott L

“…Hereditary tyrosinemia type 1 (HT1) is an autosomal recessive disease caused by deficiency in fumarylacetoacetate hydrolase, the last enzyme in the tyrosine…”
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Noninvasive 3‐dimensional imaging of liver regeneration in a mouse model of hereditary tyrosinemia type 1 using the sodium iodide symporter gene by Hickey, Raymond D., Mao, Shennen A., Amiot, Bruce, Suksanpaisan, Lukkana, Miller, Amber, Nace, Rebecca, Glorioso, Jaime, O'Connor, Michael K., Peng, Kah Whye, Ikeda, Yasuhiro, Russell, Stephen J., Nyberg, Scott L.

“…Cell transplantation is a potential treatment for the many liver disorders that are currently only curable by organ transplantation. However, one of the major…”
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