Search Results - "Hicke, B J"

A high throughput platform for systematic evolution of ligands by exponential enrichment (SELEX) by Drolet, D W, Jenison, R D, Smith, D E, Pratt, D, Hicke, B J

“…The systematic evolution of ligands by exponential enrichment (SELEX) process is a combinatorial chemistry method for the isolation of nucleic acid ligands…”
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A Tenascin-C Aptamer Identified by Tumor Cell SELEX: Systematic Evolution of Ligands by Exponential Enrichment by Daniels, Dion A., Chen, Hang, Hicke, Brian J., Swiderek, Kristine M., Gold, Larry

“…The targeting of molecular repertoires to complex systems rather than biochemically pure entities is an accessible approach that can identify proteins of…”
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DNA aptamers block L-selectin function in vivo. Inhibition of human lymphocyte trafficking in SCID mice by Hicke, B J, Watson, S R, Koenig, A, Lynott, C K, Bargatze, R F, Chang, Y F, Ringquist, S, Moon-McDermott, L, Jennings, S, Fitzwater, T, Han, H L, Varki, N, Albinana, I, Willis, M C, Varki, A, Parma, D

“…Selectins participate in the initial events leading to leukocyte extravasation from the blood into tissues. Thus the selectins have generated much interest as…”
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Identification and characterization of nuclease-stabilized RNA molecules that bind human prostate cancer cells via the prostate-specific membrane antigen by LUPOLD, Shawn E, HICKE, Brian J, YUN LIN, COFFEY, Donald S

“…We have identified two synthetic oligonucleotides (aptamers) that bind to prostate cancer cells,with low nanomolar affinity, via the extracellular portion of…”
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Photocrosslinking of 5-iodouracil-substituted RNA and DNA to proteins by WILLIS, M. C, HICKE, B. J, UHLENBECK, O. C, CECH, T. R, KOCH, T. H

“…5-Iodouracil-substituted RNA and DNA were crosslinked regiospecifically to associated proteins in yields of 70 to 94% of bound nucleic acid. Irradiation of the…”
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Escort aptamers: a delivery service for diagnosis and therapy by Hicke, B J, Stephens, A W

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Telomeric protein-DNA point contacts identified by photo-cross-linking using 5-bromodeoxyuridine by HICKE, B. J, WILLIS, M. C, KOCH, T. H, CECH, T. R

“…The Oxytricha telomere protein specifically recognizes single-stranded telomeric DNA, forming an extremely salt resistant and kinetically stable nucleoprotein…”
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Stereoselective arginine binding is a phylogenetically conserved property of group I self‐splicing RNAs by Hicke, B.J., Christian, E.L., Yarus, M.

“…We have examined the reaction of GTP with RNA polymerase transcripts containing the self‐splicing RNA precursors from the Neurospora crassa Cob1 intron, and…”
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Tenascin-C Aptamers Are Generated Using Tumor Cells and Purified Protein by Hicke, Brian J., Marion, Chris, Chang, Ying-Fon, Gould, Ty, Lynott, Cynthia K., Parma, David, Schmidt, Paul G., Warren, Steve

“…Tenascin-C (TN-C) is an extracellular matrix protein that is overexpressed during tissue remodeling processes, including tumor growth. To identify an aptamer…”
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Catalytic and noncatalytic nucleotide binding sites of the Escherichia coli F1 ATPase Amino acid sequences of β‐subunit tryptic peptides labeled with 2‐azido‐ATP by Wise, John G., Hicke, Brian J., Boyer, Paul D.

“…Under appropriate conditions tight, noncovalent binding of 2‐azido‐adenine nucleotides to either catalytic or noncatalytic binding sites on the E. coli…”
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Oxytricha telomeric nucleoprotein complexes reconstituted with synthetic DNA by RAGHURAMAN, M. K, DUNN, C. J, HICKE, B. J, CECH, T. R

“…The telomere binding protein from macronuclei of Oxytricha nova binds macronuclear DNA in vitro, protecting the 3'-terminal single-stranded (T4G4)2 tail from…”
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Post-SELEX combinatorial optimization of aptamers by Eaton, Bruce E., Gold, Larry, Hicke, Brian J., Janjié, Nebojša, Jucker, Fiona M., Sebesta, David P., Tarasow, Theodore M., Willis, Michael C., Zichi, Dominic A.

“…In vitro selection techniques provide a means of isolating nucleic acid ligands for binding to particular protein targets. Although most aptamers have quite…”
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Two Versions of the Gene Encoding the 41-Kilodalton Subunit of the Telomere Binding Protein of Oxytricha Nova by Hicke, Brian J., Celander, Daniel W., MacDonald, Gregg H., Price, Carolyn M., Cech, Thomas R.

“…Macronuclear chromosomes of the ciliated protozoan Oxytricha nova terminate with a single-stranded (T4G 4)2overhang. The (T4G 4)2telomeric overhang is…”
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Tumor Targeting by an Aptamer by Hicke, Brian J, Stephens, Andrew W, Gould, Ty, Chang, Ying-Fon, Lynott, Cynthia K, Heil, James, Borkowski, Sandra, Hilger, Christoph-Stephan, Cook, Gary, Warren, Stephen, Schmidt, Paul G

“…Aptamers are small oligonucleotides that are selected to bind tightly and specifically to a target molecule. We sought to determine whether aptamers have…”
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Catalytic and noncatalytic nucleotide binding sites of the Escherichia coli F sub(1) ATPase. Amino acid sequences of beta -subunit tryptic peptides labeled with 2-azido-ATP by Wise, J G, Hicke, B J, Boyer, P D

“…Under appropriate conditions tight, noncovalent binding of 2-azido-adenine nucleotides to either catalytic or noncatalytic binding sites on the E. coli F…”
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