Search Results - "Hibbs, Ryan E"

A Fluorescence-Detection Size-Exclusion Chromatography-Based Thermostability Assay for Membrane Protein Precrystallization Screening by Hattori, Motoyuki, Hibbs, Ryan E., Gouaux, Eric

“…Optimization of membrane protein stability under different solution conditions is essential for obtaining crystals that diffract to high resolution…”
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X-ray structure of the human α4β2 nicotinic receptor by Morales-Perez, Claudio L., Noviello, Colleen M., Hibbs, Ryan E.

“…Nicotinic acetylcholine receptors are ligand-gated ion channels that mediate fast chemical neurotransmission; here, the first X-ray crystal structure of a…”
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Structure of a human synaptic GABAA receptor by Zhu, Shaotong, Noviello, Colleen M., Teng, Jinfeng, Walsh, Richard M., Kim, Jeong Joo, Hibbs, Ryan E.

“…Fast inhibitory neurotransmission in the brain is principally mediated by the neurotransmitter GABA (γ-aminobutyric acid) and its synaptic target, the type A…”
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X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors by Althoff, Thorsten, Hibbs, Ryan E., Banerjee, Surajit, Gouaux, Eric

“…This study solved structures of the glutamate-gated chloride channel (GluCl), a Cys-loop receptor from C. elegans , in an apo , closed state and in a…”
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Manipulation of Subunit Stoichiometry in Heteromeric Membrane Proteins by Morales-Perez, Claudio L., Noviello, Colleen M., Hibbs, Ryan E.

“…The ability of oligomeric membrane proteins to assemble in different functional ratios of subunits is a common feature across many systems. Recombinant…”
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Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins by Rahman, Md. Mahfuzur, Teng, Jinfeng, Worrell, Brady T., Noviello, Colleen M., Lee, Myeongseon, Karlin, Arthur, Stowell, Michael H.B., Hibbs, Ryan E.

“…The nicotinic acetylcholine receptor, a pentameric ligand-gated ion channel, converts the free energy of binding of the neurotransmitter acetylcholine into…”
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Structural and dynamic mechanisms of GABAA receptor modulators with opposing activities by Zhu, Shaotong, Sridhar, Akshay, Teng, Jinfeng, Howard, Rebecca J., Lindahl, Erik, Hibbs, Ryan E.

“…γ-Aminobutyric acid type A (GABA A ) receptors are pentameric ligand-gated ion channels abundant in the central nervous system and are prolific drug targets…”
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Chemical and structural analysis of a photoactive vertebrate cryptochrome from pigeon by Zoltowski, Brian D., Chelliah, Yogarany, Wickramaratne, Anushka, Jarocha, Lauren, Karki, Nischal, Xu, Wei, Mouritsen, Henrik, Hore, Peter J., Hibbs, Ryan E., Green, Carla B., Takahashi, Joseph S.

“…Computational and biochemical studies implicate the blue-light sensor cryptochrome (CRY) as an endogenous light-dependent magnetosensor enabling migratory…”
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Structural mechanism of muscle nicotinic receptor desensitization and block by curare by Rahman, Md. Mahfuzur, Basta, Tamara, Teng, Jinfeng, Lee, Myeongseon, Worrell, Brady T., Stowell, Michael H. B., Hibbs, Ryan E.

“…Binding of the neurotransmitter acetylcholine to its receptors on muscle fibers depolarizes the membrane and thereby triggers muscle contraction. We sought to…”
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Structural interplay of anesthetics and paralytics on muscle nicotinic receptors by Goswami, Umang, Rahman, Md Mahfuzur, Teng, Jinfeng, Hibbs, Ryan E.

“…General anesthetics and neuromuscular blockers are used together during surgery to stabilize patients in an unconscious state. Anesthetics act mainly by…”
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Structural insights into GABAA receptor potentiation by Quaalude by Chojnacka, Weronika, Teng, Jinfeng, Kim, Jeong Joo, Jensen, Anders A., Hibbs, Ryan E.

“…Methaqualone, a quinazolinone marketed commercially as Quaalude, is a central nervous system depressant that was used clinically as a sedative-hypnotic, then…”
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Structural insights into opposing actions of neurosteroids on GABAA receptors by Legesse, Dagimhiwat H., Fan, Chen, Teng, Jinfeng, Zhuang, Yuxuan, Howard, Rebecca J., Noviello, Colleen M., Lindahl, Erik, Hibbs, Ryan E.

“…γ-Aminobutyric acid type A (GABA A ) receptors mediate fast inhibitory signaling in the brain and are targets of numerous drugs and endogenous neurosteroids. A…”
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Sensory specializations drive octopus and squid behaviour by Kang, Guipeun, Allard, Corey A. H., Valencia-Montoya, Wendy A., van Giesen, Lena, Kim, Jeong Joo, Kilian, Peter B., Bai, Xiaochen, Bellono, Nicholas W., Hibbs, Ryan E.

“…The evolution of new traits enables expansion into new ecological and behavioural niches. Nonetheless, demonstrated connections between divergence in protein…”
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Atomic interactions of neonicotinoid agonists with AChBP: Molecular recognition of the distinctive electronegative pharmacophore by Talley, Todd T, Harel, Michal, Hibbs, Ryan E, Radić, Zoran, Tomizawa, Motohiro, Casida, John E, Taylor, Palmer

“…Acetylcholine-binding proteins (AChBPs) from mollusks are suitable structural and functional surrogates of the nicotinic acetylcholine receptors when combined…”
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Principles of activation and permeation in an anion-selective Cys-loop receptor by Hibbs, Ryan E., Gouaux, Eric

“…Fast inhibitory neurotransmission is essential for nervous system function and is mediated by binding of inhibitory neurotransmitters to receptors of the…”
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Direct Structural Insights into GABAA Receptor Pharmacology by Kim, Jeong Joo, Hibbs, Ryan E.

“…GABAA receptors are pentameric ligand-gated ion channels that mediate most fast neuronal inhibition in the brain. In addition to their important physiological…”
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Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site by Brams, Marijke, Govaerts, Cedric, Kambara, Kumiko, Price, Kerry L, Spurny, Radovan, Gharpure, Anant, Pardon, Els, Evans, Genevieve L, Bertrand, Daniel, Lummis, Sarah CR, Hibbs, Ryan E, Steyaert, Jan, Ulens, Chris

“…Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors are involved in fast synaptic signaling in the nervous system. Allosteric modulators bind…”
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A simple flash and freeze system for cryogenic time-resolved electron microscopy by Bhattacharjee, Biddut, Rahman, Md Mahfuzur, Hibbs, Ryan E, Stowell, Michael H B

“…As the resolution revolution in CryoEM expands to encompass all manner of macromolecular complexes, an important new frontier is the implementation of…”
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Structure of a human synaptic GABA A receptor by Zhu, Shaotong, Noviello, Colleen M, Teng, Jinfeng, Walsh, Jr, Richard M, Kim, Jeong Joo, Hibbs, Ryan E

“…Fast inhibitory neurotransmission in the brain is principally mediated by the neurotransmitter GABA (γ-aminobutyric acid) and its synaptic target, the type A…”
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Structure and gating mechanism of the α7 nicotinic acetylcholine receptor by Noviello, Colleen M., Gharpure, Anant, Mukhtasimova, Nuriya, Cabuco, Rico, Baxter, Leah, Borek, Dominika, Sine, Steven M., Hibbs, Ryan E.

“…The α7 nicotinic acetylcholine receptor plays critical roles in the central nervous system and in the cholinergic inflammatory pathway. This ligand-gated ion…”
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