Search Results - "Hibbs, Ryan"

Principles of activation and permeation in an anion-selective Cys-loop receptor by Hibbs, Ryan E., Gouaux, Eric

“…Fast inhibitory neurotransmission is essential for nervous system function and is mediated by binding of inhibitory neurotransmitters to receptors of the…”
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Direct Structural Insights into GABAA Receptor Pharmacology by Kim, Jeong Joo, Hibbs, Ryan E.

“…GABAA receptors are pentameric ligand-gated ion channels that mediate most fast neuronal inhibition in the brain. In addition to their important physiological…”
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A Fluorescence-Detection Size-Exclusion Chromatography-Based Thermostability Assay for Membrane Protein Precrystallization Screening by Hattori, Motoyuki, Hibbs, Ryan E., Gouaux, Eric

“…Optimization of membrane protein stability under different solution conditions is essential for obtaining crystals that diffract to high resolution…”
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Structure of a human synaptic GABA A receptor by Zhu, Shaotong, Noviello, Colleen M, Teng, Jinfeng, Walsh, Jr, Richard M, Kim, Jeong Joo, Hibbs, Ryan E

“…Fast inhibitory neurotransmission in the brain is principally mediated by the neurotransmitter GABA (γ-aminobutyric acid) and its synaptic target, the type A…”
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X-ray structure of the human α4β2 nicotinic receptor by Morales-Perez, Claudio L., Noviello, Colleen M., Hibbs, Ryan E.

“…Nicotinic acetylcholine receptors are ligand-gated ion channels that mediate fast chemical neurotransmission; here, the first X-ray crystal structure of a…”
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Structure and gating mechanism of the α7 nicotinic acetylcholine receptor by Noviello, Colleen M., Gharpure, Anant, Mukhtasimova, Nuriya, Cabuco, Rico, Baxter, Leah, Borek, Dominika, Sine, Steven M., Hibbs, Ryan E.

“…The α7 nicotinic acetylcholine receptor plays critical roles in the central nervous system and in the cholinergic inflammatory pathway. This ligand-gated ion…”
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Structural switch in acetylcholine receptors in developing muscle by Li, Huanhuan, Teng, Jinfeng, Hibbs, Ryan E.

“…During development, motor neurons originating in the brainstem and spinal cord form elaborate synapses with skeletal muscle fibres 1 . These neurons release…”
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Structure of a human synaptic GABAA receptor by Zhu, Shaotong, Noviello, Colleen M., Teng, Jinfeng, Walsh, Richard M., Kim, Jeong Joo, Hibbs, Ryan E.

“…Fast inhibitory neurotransmission in the brain is principally mediated by the neurotransmitter GABA (γ-aminobutyric acid) and its synaptic target, the type A…”
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Progress in nicotinic receptor structural biology by Gharpure, Anant, Noviello, Colleen M., Hibbs, Ryan E.

“…Here we begin by briefly reviewing landmark structural studies on the nicotinic acetylcholine receptor. We highlight challenges that had to be overcome to push…”
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X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors by Althoff, Thorsten, Hibbs, Ryan E., Banerjee, Surajit, Gouaux, Eric

“…This study solved structures of the glutamate-gated chloride channel (GluCl), a Cys-loop receptor from C. elegans , in an apo , closed state and in a…”
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Manipulation of Subunit Stoichiometry in Heteromeric Membrane Proteins by Morales-Perez, Claudio L., Noviello, Colleen M., Hibbs, Ryan E.

“…The ability of oligomeric membrane proteins to assemble in different functional ratios of subunits is a common feature across many systems. Recombinant…”
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Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins by Rahman, Md. Mahfuzur, Teng, Jinfeng, Worrell, Brady T., Noviello, Colleen M., Lee, Myeongseon, Karlin, Arthur, Stowell, Michael H.B., Hibbs, Ryan E.

“…The nicotinic acetylcholine receptor, a pentameric ligand-gated ion channel, converts the free energy of binding of the neurotransmitter acetylcholine into…”
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Structural and dynamic mechanisms of GABAA receptor modulators with opposing activities by Zhu, Shaotong, Sridhar, Akshay, Teng, Jinfeng, Howard, Rebecca J., Lindahl, Erik, Hibbs, Ryan E.

“…γ-Aminobutyric acid type A (GABA A ) receptors are pentameric ligand-gated ion channels abundant in the central nervous system and are prolific drug targets…”
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Structural mechanisms of GABAA receptor autoimmune encephalitis by Noviello, Colleen M., Kreye, Jakob, Teng, Jinfeng, Prüss, Harald, Hibbs, Ryan E.

“…Autoantibodies targeting neuronal membrane proteins can cause encephalitis, seizures, and severe behavioral abnormalities. While antibodies for several…”
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Shared structural mechanisms of general anaesthetics and benzodiazepines by Kim, Jeong Joo, Gharpure, Anant, Teng, Jinfeng, Zhuang, Yuxuan, Howard, Rebecca J., Zhu, Shaotong, Noviello, Colleen M., Walsh, Richard M., Lindahl, Erik, Hibbs, Ryan E.

“…Most general anaesthetics and classical benzodiazepine drugs act through positive modulation of γ-aminobutyric acid type A (GABA A ) receptors to dampen…”
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Structural principles of distinct assemblies of the human α4β2 nicotinic receptor by Walsh, Richard M., Roh, Soung-Hun, Gharpure, Anant, Morales-Perez, Claudio L., Teng, Jinfeng, Hibbs, Ryan E.

“…Fast chemical communication in the nervous system is mediated by neurotransmitter-gated ion channels. The prototypical member of this class of cell surface…”
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Chemical and structural analysis of a photoactive vertebrate cryptochrome from pigeon by Zoltowski, Brian D., Chelliah, Yogarany, Wickramaratne, Anushka, Jarocha, Lauren, Karki, Nischal, Xu, Wei, Mouritsen, Henrik, Hore, Peter J., Hibbs, Ryan E., Green, Carla B., Takahashi, Joseph S.

“…Computational and biochemical studies implicate the blue-light sensor cryptochrome (CRY) as an endogenous light-dependent magnetosensor enabling migratory…”
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Structural mechanism of muscle nicotinic receptor desensitization and block by curare by Rahman, Md. Mahfuzur, Basta, Tamara, Teng, Jinfeng, Lee, Myeongseon, Worrell, Brady T., Stowell, Michael H. B., Hibbs, Ryan E.

“…Binding of the neurotransmitter acetylcholine to its receptors on muscle fibers depolarizes the membrane and thereby triggers muscle contraction. We sought to…”
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Agonist Selectivity and Ion Permeation in the α3β4 Ganglionic Nicotinic Receptor by Gharpure, Anant, Teng, Jinfeng, Zhuang, Yuxuan, Noviello, Colleen M., Walsh, Richard M., Cabuco, Rico, Howard, Rebecca J., Zaveri, Nurulain T., Lindahl, Erik, Hibbs, Ryan E.

“…Nicotinic acetylcholine receptors are pentameric ion channels that mediate fast chemical neurotransmission. The α3β4 nicotinic receptor subtype forms the…”
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Structural bases for stoichiometry‐selective calcium potentiation of a neuronal nicotinic receptor by Mazzaferro, Simone, Kang, Guipeun, Natarajan, Kathiresan, Hibbs, Ryan E., Sine, Steven M.

“…Background and Purpose α4β2 nicotinic acetylcholine (nACh) receptors assemble in two stoichiometric forms, one of which is potentiated by calcium. The sites of…”
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