Search Results - "Heylings, Jon"

Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens by Holmes, Amy M., Heylings, Jon R., Wan, Ka-Wai, Moss, Gary P.

“…•Antimicrobial efficacy of PAMAM dendrimers depends on generation and concentration.•Terminal functionalities are also significant contributors to…”
Get full text

Dermal absorption of testosterone in human and pig skin in vitro by Heylings, Jon R., Davies, Diane J., Burton, Rebecca

“…The OECD test guideline 428 for the assessment of dermal absorption in vitro has been in force for more than a decade. Various sectors of industry utilise the…”
Get full text

Development of an in vitro model for studying the penetration of chemicals through compromised skin by Davies, Diane J., Heylings, Jon R., McCarthy, Timothy J., Correa, Catherine M.

“…•Tape stripping has been evaluated to develop an in vitro model of compromised skin.•Electrical Resistance, Trans-Epidermal Water Loss and Tritiated Water Flux…”
Get full text

Dendrimer pre-treatment enhances the skin permeation of chlorhexidine digluconate: Characterisation by in vitro percutaneous absorption studies and Time-of-Flight Secondary Ion Mass Spectrometry by Holmes, Amy M., Scurr, David J., Heylings, Jon R., Wan, Ka-Wai, Moss, Gary P.

“…Skin penetration and localisation of chlorhexidine digluconate (CHG) within the skin have been investigated in order to better understand and optimise the…”
Get full text

Further development of an in vitro model for studying the penetration of chemicals through compromised skin by Davies, Diane J, Heylings, Jon R, Gayes, Heather, McCarthy, Timothy J, Mack, M Catherine

“…A new in vitro model based on the electrical resistance properties of the skin barrier has been established in this laboratory. The model utilises a tape…”
Get full text

Distribution and Visualisation of Chlorhexidine Within the Skin Using ToF-SIMS: A Potential Platform for the Design of More Efficacious Skin Antiseptic Formulations by Judd, Amy M., Scurr, David J., Heylings, Jon R., Wan, Ka-Wai, Moss, Gary P.

“…ABSTRACT Purpose In order to increase the efficacy of a topically applied antimicrobial compound the permeation profile, localisation and mechanism of action…”
Get full text

Dermal absorption for pesticide health risk assessment: Harmonization of study design and data reporting for North American Regulatory submissions by Sullivan, Kristie M., Aggarwal, Manoj, Akins, Jonathan M., Fabian, Eric, Heylings, Jon R., Raabe, Hans, Shah, Prakashchandra (P.V.), Wiemann, Christiane, Peffer, Richard

“…Although an internationally-adopted in vitro dermal absorption test guideline is available (OECD Test Guideline 428), the replacement of the in vivo approach…”
Get full text

ECVAM international validation study on in vitro tests for acute skin irritation: report on the validity of the EPISKIN and EpiDerm assays and on the Skin Integrity Function Test by Spielmann, Horst, Hoffmann, Sebastian, Liebsch, Manfred, Botham, Phil, Fentem, Julia H, Eskes, Chantra, Roguet, Roland, Cotovio, José, Cole, Thomas, Worth, Andrew, Heylings, Jon, Jones, Penny, Robles, Catherine, Kandárova, Helena, Gamer, Armin, Remmele, Marina

“…ECVAM sponsored a formal validation study on three in vitro tests for skin irritation, of which two employ reconstituted human epidermis models (EPISKIN,…”
Get full text

OECD 428 in vitro dermal absorption mass balance performance based on our in-house database of pesticide studies by Heylings, Jon

Get full text

Skin sensitization potency of methyl methacrylate in the local lymph node assay: comparisons with guinea-pig data and human experience by Betts, Catherine J., Dearman, Rebecca J., Heylings, Jon R., Kimber, Ian, Basketter, David A.

“…There is compelling evidence that contact allergens differ substantially (by 4 or 5 orders of magnitude) with respect to their inherent skin‐sensitizing…”
Get full text

Follow-up to the ECVAM prevalidation study on in vitro tests for acute skin Irritation. ECVAM Skin Irritation Task Force Report 2 by ZUANG, Valérie, BALLS, Michael, MEDINA, Jesus, ROGUET, Roland, VAN DE SANDT, Johannes J. M, WIEMANN, Christianne, WORTH, Andrew P, BOTHAM, Philip A, COQUETTE, Alain, CORSINI, Emanuela, CURREN, Rodger D, ELLIOTT, Graham R, FENTEM, Julia H, HEYLINGS, Jon R, LIEBSCH, Manfred

“…The European Centre for the Validation of Alternative Methods (ECVAM) Skin Irritation Task Force was established in 1996, to review the status of the…”
Get full text

Skin absorption and penetration by Diembeck, Walter, Eskes, Chantra, Heylings, Jon R, Langley, Gill, Rogiers, Vera, van de Sandt, Johannes J M, Zuang, Valérie

Get full text

Diquat-induced intestinal secretion in the anaesthetized rat by Rawlings, J M, Foster, J R, Heylings, J R

“…1. Diquat (1,1'-ethylene-2,2'-bipyridilium) is a non-selective desiccant herbicide which, when administered orally to mammalian species, causes significant…”
Get more information

Effects of antiinflammatory agents and prostaglandins on acid and bicarbonate secretions in the amphibian-isolated gastric mucosa by Garner, A, Flemström, G, Heylings, J R

“…Effects of antiinflammatory agents and prostaglandins on H+ and HCO-3 secretions and electrical properties were investigated in the amphibian-isolated gastric…”
Get more information

3.5. Skin Absorption and Penetration by Diembeck, Walter, Eskes, Chantra, Heylings, Jon R., Langley, Gill, Rogiers, Vera, van de Sandt, Johannes J.M., Zuang, Valérie

Get full text

W. R. Heylings MRCGP by Heylings, Jon

Get full text

Percutaneous absorption and metabolism of dinitrochlorobenzene in vitro by JEWELL, Christopher, HEYLINGS, Jon, CLOWES, Helen M, WILLIAMS, Faith M

“…Dinitrochlorobenzene (DNCB) absorption through mouse and rat dorsal skin, pig ear skin and human abdominal skin in vitro was determined, and local metabolism…”
Get full text

The ECVAM International Validation Study on In Vitro Tests for Acute Skin Irritation : Report on the Validity of the EPISKIN and EpiDerm Assays and on the Skin Integrity Function Testa by SPIELMANN, Horst, HOFFMANN, Sebastian, HEYLINGS, Jon, JONES, Penny, ROBLES, Catherine, KANDAROVA, Helena, GAMER, Armin, REMMELE, Marina, CURREN, Rodger, RAABE, Hans, COCKSHOTT, Amanda, GERNER, Ingrid, LIEBSCH, Manfred, ZUANG, Valérie, BOTHAM, Phil, FENTEM, Julia H, ESKES, Chantra, ROGUET, Roland, COTOVIO, José, COLE, Thomas, WORTH, Andrew

Get full text

Skin absorption and penetration: Alternative (Non-Animal) methods for cosmetic testing: current status and future prospects. A report prepared in the contest of the 7th Amendment to the Cosmetic Directive for Establishing the Timetable for Phasing Out Anima l Testing by DIEMBECK, Walter, ESKES, Chantra, HEYLINGS, Jon R, LANGLEY, Gill, ROGIERS, Vera, VAN DE SANDT, Johannes J. M, ZUANG, Valéric

Get full text

Follow-up to the ECVAM prevalidation study on in vitro tests for acute skin irritation. The European Centre for the Validation of Alternative Methods Skin Irritation Task Force report 2 by Zuang, Valérie, Balls, Michael, Botham, Philip A, Coquette, Alain, Corsini, Emanuela, Curren, Rodger D, Elliott, Graham R, Fentem, Julia H, Heylings, Jon R, Liebsch, Manfred, Medina, Jesús, Roguet, Roland, van de Sandt, Johannes J M, Wiemann, Christianne, Worth, Andrew P

“…The European Centre for the Validation of Alternative Methods (ECVAM) Skin Irritation Task Force was established in 1996, to review the status of the…”
Get full text