Search Results - "Heylings, J.R."

A multi-laboratory evaluation of a common in vitro pepsin digestion assay protocol used in assessing the safety of novel proteins by Thomas, K., Aalbers, M., Bannon, G.A., Bartels, M., Dearman, R.J., Esdaile, D.J., Fu, T.J., Glatt, C.M., Hadfield, N., Hatzos, C., Hefle, S.L., Heylings, J.R., Goodman, R.E., Henry, B., Herouet, C., Holsapple, M., Ladics, G.S., Landry, T.D., MacIntosh, S.C., Rice, E.A., Privalle, L.S., Steiner, H.Y., Teshima, R., van Ree, R., Woolhiser, M., Zawodny, J.

“…Rationale. Evaluation of the potential allergenicity of proteins derived from genetically modified foods has involved a weight of evidence approach that…”
Get full text

Identification of an alginate-based formulation of paraquat to reduce the exposure of the herbicide following oral ingestion by Heylings, J.R, Farnworth, M.J, Swain, C.M, Clapp, M.J, Elliott, B.M

“…Abstract The herbicide paraquat has been widely used throughout the world for almost 50 years and is important in sustainable agriculture. When used correctly…”
Get full text

Multi-species assessment of electrical resistance as a skin integrity marker for in vitro percutaneous absorption studies by Davies, D.J., Ward, R.J., Heylings, J.R.

“…Assessment of percutaneous absorption in vitro provides key information when predicting dermal absorption in vivo. Confirmation of skin membrane integrity is…”
Get full text

A prevalidation study on in vitro tests for acute skin irritation by Fentem, J.H, Briggs, D, Chesné, C, Elliott, G.R, Harbell, J.W, Heylings, J.R, Portes, P, Roguet, R, van de Sandt, J.J.M, Botham, P.A

Get full text

A prevalidation study on in vitro tests for acute skin irritation: results and evaluation by the Management Team by Fentem, J.H, Briggs, D, Chesné, C, Elliott, G.R, Harbell, J.W, Heylings, J.R, Portes, P, Roguet, R, van de Sandt, J.J.M, Botham, P.A

“…A prevalidation study on in vitro tests for acute skin irritation was conducted during 1999 and 2000. The overall objective of validation in this area, of…”
Get full text

A prevalidation study on the in vitro skin irritation function test (SIFT) for prediction of acute skin irritation in vivo: results and evaluation of ECVAM Phase III by Heylings, J.R., Diot, S., Esdaile, D.J., Fasano, W.J., Manning, L.A., Owen, H.M.

“…A prevalidation study sponsored by the European Centre for the Validation of Alternative Methods (ECVAM) on in vitro tests for acute skin irritation is aimed…”
Get full text

Comparison of tissue sources for the skin integrity function test (SIFT) by Heylings, J.R, Clowes, H.M, Hughes, L

“…One of the in vitro models involved in an ECVAM-sponsored prevalidation study for acute skin irritation is the skin integrity function test (SIFT), which…”
Get full text

111 A multi-laboratory evaluation of a common in vitro pepsin digestion assay protocol used in assessing the safety of novel proteins by Esdaile, D.J., Bannon, G.A., Bartels, M., Dearman, R.J., Fu, T.J., Glatt, C.M., Hadfield, N., Hefle, S.L., Heylings, J.R., Goodman, R.E., Henry, B., Herouet, C., Holsapple, M., Ladics, G.S., Landry, T.D., MacIntosh, S.C., Rice, E.A., Privalle, L.S., Steiner, H.Y., Teshima, R., Thomas, K., van Ree, R., Woolhiser, M., Zawodny, J.

Get full text

Sensitization to 2,4-dinitrochlorobenzene: influence of vehicle on absorption and lymph node activation by Heylings, J.R., Clowes, H.M., Cumberbatch, M., Dearman, R.J., Fielding, I., Hilton, J., Kimber, I.

“…Effective skin sensitization is dependent upon immune activation of lymph nodes draining the site of exposure. The influence of vehicle formulation on the…”
Get full text

Gastrointestinal absorption of paraquat in the isolated mucosa of the rat by Heylings, J R

“…The gastrointestinal absorption of paraquat (1,1'-dimethyl-4,4'-bipyridylium) was studied using the isolated mucosa from different regions of the…”
Get more information

Endogenous E-type prostaglandins in regulation of basal alkaline secretion by amphibian duodenum in vitro by Heylings, J R, Hampson, S E, Garner, A

“…Segments of proximal duodenum from Rana catesbeiana, stripped of external muscle and mounted as a tube in a glass chamber, alkalinized the luminal-side bathing…”
Get more information

Influence of Dibutyl Phthalate on Dermal Sensitization to Fluorescein Isothiocyanate by Dearman, R.J., Cumberbatch, M., Hilton, J., Clowes, H.M., Fielding, I., Heylings, J.R., Kimber, I.

“…What limited evidence there is indicates that the formulation in which a chemical allergen is encountered on the skin can have a marked impact upon the…”
Get full text