Search Results - "Heylen, Elien"

The ins and outs of serine and glycine metabolism in cancer by Geeraerts, Shauni L., Heylen, Elien, De Keersmaecker, Kim, Kampen, Kim R.

“…Cancer cells reprogramme their metabolism to support unrestrained proliferation and survival in nutrient-poor conditions. Whereas non-transformed cells often…”
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Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis-Addicted Breast Tumor Growth by Geeraerts, Shauni Lien, Kampen, Kim Rosalie, Rinaldi, Gianmarco, Gupta, Purvi, Planque, Mélanie, Louros, Nikolaos, Heylen, Elien, De Cremer, Kaat, De Brucker, Katrijn, Vereecke, Stijn, Verbelen, Benno, Vermeersch, Pieter, Schymkowitz, Joost, Rousseau, Frederic, Cassiman, David, Fendt, Sarah-Maria, Voet, Arnout, Cammue, Bruno P A, Thevissen, Karin, De Keersmaecker, Kim

“…Metabolic rewiring is a hallmark of cancer that supports tumor growth, survival, and chemotherapy resistance. Although normal cells often rely on extracellular…”
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Carfilzomib-induced reticulocytosis in patients with multiple myeloma is caused by impaired terminal erythroid maturation by Kint, Nicolas G., Heylen, Elien, Pepe, Daniele, De Keersmaecker, Kim, Verfaillie, Catherine M., Delforge, Michel

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Transcription factor NKX2–1 drives serine and glycine synthesis addiction in cancer by Heylen, Elien, Verstraete, Paulien, Van Aerschot, Linde, Geeraerts, Shauni L., Venken, Tom, Timcheva, Kalina, Nittner, David, Verbeeck, Jelle, Royaert, Jonathan, Gijbels, Marion, Uyttebroeck, Anne, Segers, Heidi, Lambrechts, Diether, Cools, Jan, De Keersmaecker, Kim, Kampen, Kim R.

“…Background One-third of cancers activate endogenous synthesis of serine/glycine, and can become addicted to this pathway to sustain proliferation and survival…”
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Proteasome Inhibition By Carfilzomib Impairs Terminal Erythroid Maturation and Causes Reticulocytosis in Patients with Multiple Myeloma by Kint, Nicolas, Heylen, Elien, De Keersmaecker, Kim, Verfaillie, Catherine M., Delforge, Michel

“…Introduction The ubiquitin-proteasome system (UPS) is crucial for cellular protein homeostasis by ensuring the degradation of redundant or misfolded proteins…”
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1866: Targeting serine/glycine metabolism improves radiotherapy response in Non-Small Cell Lung Cancer by Castillo, Anaís Sánchez, Heylen, Elien, Hounjet, Judith, Savelkouls, Kim G., Lieuwes, Natasja G., Biemans, Rianne, Dubois, Ludwig J., Reynders, Kobe, Rouschop, Kasper M., Vaes, Rianne D.W., De Keersmaecker, Kim, Lambrecht, Maarten, Hendricks, Lizza E.L., De Ruysscher, Dirk K.M., Vooijs, Marc, Kampen, Kim R.

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Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer by Sánchez-Castillo, Anaís, Heylen, Elien, Hounjet, Judith, Savelkouls, Kim G., Lieuwes, Natasja G., Biemans, Rianne, Dubois, Ludwig J., Reynders, Kobe, Rouschop, Kasper M., Vaes, Rianne D. W., De Keersmaecker, Kim, Lambrecht, Maarten, Hendriks, Lizza E. L., De Ruysscher, Dirk K. M., Vooijs, Marc, Kampen, Kim R.

“…Background Lung cancer is the most lethal cancer, and 85% of cases are classified as non-small cell lung cancer (NSCLC). Metabolic rewiring is a cancer…”
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Correction: Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer by Sánchez-Castillo, Anaís, Heylen, Elien, Hounjet, Judith, Savelkouls, Kim G., Lieuwes, Natasja G., Biemans, Rianne, Dubois, Ludwig J., Reynders, Kobe, Rouschop, Kasper M., Vaes, Rianne D. W., De Keersmaecker, Kim, Lambrecht, Maarten, Hendriks, Lizza E. L., De Ruysscher, Dirk K. M., Vooijs, Marc, Kampen, Kim R.

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