Search Results - "Heyes, M P"

Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease by Heyes, M P, Saito, K, Crowley, J S, Davis, L E, Demitrack, M A, Der, M, Dilling, L A, Elia, J, Kruesi, M J, Lackner, A

“…Neurological dysfunction, seizures and brain atrophy occur in a broad spectrum of acute and chronic neurological diseases. In certain instances,…”
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Glutamate is a mediator of neurotoxicity in secretions of activated HIV-1-infected macrophages by Jiang, Z.-G, Piggee, C, Heyes, M.P, Murphy, C, Quearry, B, Bauer, M, Zheng, J, Gendelman, H.E, Markey, S.P

“…We sought to identify neurotoxin(s) secreted by HIV-1-infected mononuclear phagocytes that could contribute to the pathophysiology of HIV-1-associated dementia…”
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Human macrophages convert L-tryptophan into the neurotoxin quinolinic acid by HEYES, M. P, SAITO, K, MARKEY, S. P

“…Substantial increases in the concentrations of the excitotoxin and N-methyl-D-aspartate-receptor agonist quinolinic acid (QUIN) occur in human patients and…”
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A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate by Heyes, M P, Saito, K, Major, E O, Milstien, S, Markey, S P, Vickers, J H

“…Quinolinic acid (QUIN), kynurenic acid (KYNA) and L-kynurenine (L-KYN) are neuroactive kynurenine pathway metabolites that accumulate in inflammatory…”
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Elevated cerebrospinal fluid quinolinic acid levels are associated with region-specific cerebral volume loss in HIV infection by Heyes, Melvyn P., Ellis, Ronald J., Ryan, Lee, Childers, Meredith E., Grant, Igor, Wolfson, Tanya, Archibald, Sarah, Jernigan, Terry L.

“…Neuronal injury, dendritic loss and brain atrophy are frequent complications of infection with human immunodeficiency virus (HIV) type 1. Activated brain…”
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Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse by Saito, K, Markey, S P, Heyes, M P

“…Accumulation of quinolinic acid and neuroactive kynurenines derived from tryptophan are of potential significance in human neuropathologic diseases because of…”
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A mechanism for increased quinolinic acid formation following acute systemic immune stimulation by SAITO, K, CROWLEY, J. S, MARKEY, S. P, HEYES, M. P

“…Mechanisms for increased levels of quinolinic acid (QUIN) following systemic immune stimulation were investigated. In gerbils, systemic administration of…”
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Quantitation of human immunodeficiency virus, immune activation factors, and quinolinic acid in AIDS brains by ACHIM, C. L, HEYES, M. P, WILEY, C. A

“…HIV encephalitis is unusual in that neurologic damage occurs in the absence of significant infection of neuronal or glial cells. Because the predominant…”
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Effects of methylprednisolone and 4-chloro-3-hydroxyanthranilic acid in experimental spinal cord injury in the guinea pig appear to be mediated by different and potentially complementary mechanisms by Yates, J R, Gay, E A, Heyes, M P, Blight, A R

“…Study design: Blinded, placebo-controlled, parallel treatment group studies of the effects of methylprednisolone (MP) or 4-chloro-3-hydroxyanthranilate…”
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Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical and neurological status by Heyes, M P, Brew, B J, Martin, A, Price, R W, Salazar, A M, Sidtis, J J, Yergey, J A, Mouradian, M M, Sadler, A E, Keilp, J

“…Quinolinic acid is an "excitotoxic" metabolite and an agonist of N-methyl-D-aspartate receptors. Of patients infected with human immunodeficiency virus type 1…”
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4-chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-γ-stimulated monocytes (THP-1 cells) by SAITO, K, CHEN, C. Y, MASANA, M, CROWLEY, J. S, MARKEY, S. P, HEYES, M. P

“…Accumulation of quinolinic acid and L-kynurenine occurs in the brain and/or blood following immune activation, and may derive from L-tryptophan following…”
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Prospective study of neurological responses to treatment with macrophage-targeted glucocerebrosidase in patients with type 3 Gaucher's disease by Schiffmann, R, Heyes, M P, Aerts, J M, Dambrosia, J M, Patterson, M C, DeGraba, T, Parker, C C, Zirzow, G C, Oliver, K, Tedeschi, G, Brady, R O, Barton, N W

“…We prospectively evaluated the clinical and biochemical responses to enzyme-replacement therapy (ERT) with macrophage-targeted glucocerebrosidase (Ceredase)…”
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Quantification of Local De Novo Synthesis Versus Blood Contributions to Quinolinic Acid Concentrations in Brain and Systemic Tissues by Heyes, Melvyn P., Morrison, Paul F.

“…: The source of the neurotoxin quinolinic acid (QUIN) in brain and systemic tissues under normal and pathologic circumstances reflects either de novo synthesis…”
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Early intrathecal events in rhesus macaques (Macaca mulatta) infected with pathogenic or nonpathogenic molecular clones of simian immunodeficiency virus by Smith, M O, Heyes, M P, Lackner, A A

“…Encephalitis is a common and devastating sequela of HIV infection in humans and of simian immunodeficiency virus (SIV) infection in rhesus macaques. We used…”
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Metabolism and neuropathologic significance of quinolinic acid and kynurenic acid by Heyes, M P

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Quinolinic Acid In Vivo Synthesis Rates, Extracellular Concentrations, and Intercompartmental Distributions in Normal and Immune‐Activated Brain as Determined by Multiple‐Isotope Microdialysis by Beagles, Karen E., Morrison, Paul F., Heyes, Melvyn P.

“…: Quinolinic acid (QUIN) kills neurons by activation of NMDA receptors that are accessed via the extracellular fluid (ECF). In vivo microdialysis was employed…”
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Mechanism of delayed increases in kynurenine pathway metabolism in damaged brain regions following transient cerebral ischemia by Saito, K, Nowak, Jr, T S, Markey, S P, Heyes, M P

“…Delayed increases in the levels of an endogenous N-methyl-D-aspartate receptor agonist, quinolinic acid (QUIN), have been demonstrated following transient…”
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Neuroactive kynurenines in Lyme borreliosis by HALPERIN, J. J, HEYES, M. P

“…Although neurologic dysfunction occurs frequently in patients with Lyme borreliosis, it is rarely possible to demonstrate the causative organism within the…”
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Quinolinic acid is increased in CSF and associated with mortality after traumatic brain injury in humans by Sinz, E H, Kochanek, P M, Heyes, M P, Wisniewski, S R, Bell, M J, Clark, R S, DeKosky, S T, Blight, A R, Marion, D W

“…We tested the hypothesis that quinolinic acid, a tryptophan-derived N-methyl-D-aspartate agonist produced by macrophages and microglia, would be increased in…”
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Conditioned Immune Response to Interferon-γ in Humans by Longo, D.L., Duffey, P.L., Kopp, W.C., Heyes, M.P., Alvord, W.G., Sharfman, W.H., Schmidt, P.J., Rubinow, D.R., Rosenstein, D.L.

“…We determined whether a classical conditioning paradigm may be used to condition immunologic responses in normal human subjects receiving an optimal…”
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