Search Results - "Heydrick, Stanley J"

Substance P is an early mediator of peritoneal fibrinolytic pathway genes and promotes intra-abdominal adhesion formation by Esposito, Anthony J., BA, Heydrick, Stanley J., PhD, Cassidy, Michael R., MD, Gallant, Joseph, MD, Stucchi, Arthur F., PhD, Becker, James M., MD, FACS

“…Abstract Background The substance P (SP) or neurokinin-1 receptor pathway has been implicated in intra-abdominal adhesion formation, in large part through its…”
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Combined intraoperative administration of a histone deacetylase inhibitor and a neurokinin-1 receptor antagonist synergistically reduces intra-abdominal adhesion formation in a rat model by Cassidy, Michael R., MD, Sherburne, Alan C., MD, Heydrick, Stanley J., PhD, Stucchi, Arthur F., PhD

“…Background Intra-abdominal adhesions are the most frequent postoperative complication after abdominopelvic surgery. Our laboratory has previously shown that an…”
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Intraperitoneal Administration of Methylene Blue Attenuates Oxidative Stress, Increases Peritoneal Fibrinolysis, and Inhibits Intraabdominal Adhesion Formation by Heydrick, Stanley J., Ph.D, Reed, Karen L., Ph.D, Cohen, Philip A., M.D, Aarons, Cary B., M.D, Gower, Adam C., M.S, Becker, James M., M.D, Stucchi, Arthur F., Ph.D

“…Background Mounting evidence indicates that postoperative oxidative stress may be linked to decreased fibrinolytic activity and, subsequently, the development…”
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l-homocysteine and l-homocystine stereospecifically induce endothelial nitric oxide synthase-dependent lipid peroxidation in endothelial cells by Heydrick, Stanley J, Weiss, Norbert, Thomas, Shane R, Cap, Andre P, Pimentel, David R, Loscalzo, Joseph, Keaney, John F

“…Atherothrombotic cardiovascular disease associated with hyperhomocysteinemia has been proposed to result, at least in part, from increased vascular oxidative…”
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Comparison between Patients Hospitalized with Influenza and COVID-19 at a Tertiary Care Center by Donnino, Michael W., Moskowitz, Ari, Thompson, Garrett S., Heydrick, Stanley J., Pawar, Rahul D, Berg, Katherine M., Mehta, Shivani, Patel, Parth V., Grossestreuer, Anne V.

“…Background Widespread reports suggest the characteristics and disease course of coronavirus disease 2019 (COVID-19) and influenza differ, yet detailed…”
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A neurokinin-1 receptor antagonist that reduces intra-abdominal adhesion formation decreases oxidative stress in the peritoneum by Reed, Karen L, Heydrick, Stanley J, Aarons, Cary B, Prushik, Scott, Gower, Adam C, Stucchi, Arthur F, Becker, James M

“…Oxidative stress has been implicated in intra-abdominal adhesion formation. Substance P, a neurokinin-1 receptor (NK-1R) ligand, facilitates leukocyte…”
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Influence of hyperhomocysteinemia on the cellular redox state--impact on homocysteine-induced endothelial dysfunction by Weiss, Norbert, Heydrick, Stanley J, Postea, Otilia, Keller, Christiane, Keaney, Jr, John F, Loscalzo, Joseph

“…Hyperhomocysteinemia is an independent risk factor for the development of atherosclerosis. An increasing body of evidence has implicated oxidative stress as…”
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Enhanced stimulation of diacylglycerol and lipid synthesis by insulin in denervated muscle. Altered protein kinase C activity and possible link to insulin resistance by Heydrick, S J, Ruderman, N B, Kurowski, T G, Adams, H B, Chen, K S

“…Denervated muscle is generally regarded as insulin resistant because the ability of insulin to stimulate glucose transport and glycogen synthesis is impaired…”
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Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle by KUROWSKI, T. G, YENSHOU LIN, ZHIJUN LUO, TSICHLIS, P. N, BUSE, M. G, HEYDRICK, S. J, RUDERMAN, N. B

“…Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle. T G Kurowski , Y Lin , Z Luo ,…”
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Hypoxia dysregulates fibrinolytic pathways in cultured human mesothelial cells (HMCs): Implications for intraabdominal adhesion formation by Currie, Brian, Heydrick, Stanley J, Stucchi, Arthur F

“…Abstract only Abdominal surgery induces mesothelial injury and the extravasation of a fibrinous exudate into the peritoneum. The ensuing deposition of a fibrin…”
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Hypoxia and cytokines differentially regulate the expression of the tissue plasminogen activator (tPA) and plasminogen activator inhibitor‐1 (PAI‐1) genes in cultured human mesothelial cells (HMCs): Implications for post‐surgical peritoneal fibrinolytic dysregulation by Keenan, Benjamin J, Currie, Brian M, Heydrick, Stanley J, Stucchi, Arthur F

“…Abstract only Abdominal surgery induces mesothelial hypoxia and inflammation, both implicated in the dysregulation of the peritoneal fibrinolytic system and…”
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Antioxidants Increase Tissue Plasminogen Activator (tPA) Synthesis in Human Mesothelial Cells via MAPK Activation Signals by Reed, Karen L, Gower, Adam C, Heydrick, Stanley J, Stucchi, Arthur F, Becker, James M

“…Abstract only Peritoneal adhesions, a major complication of abdominal surgery, are due, in part, to reduced levels of postoperative peritoneal tPA, an enzyme…”
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Antioxidants increase tissue plasminogen activator (tPA) levels in human mesothelial cells by Reed, Karen L, Heydrick, Stanley J, Gower, Adam C, Stucchi, Arthur F, Leeman, Susan E, Becker, James M

“…Abdominal operations are thought to impair local fibrinolytic activity, thereby allowing adhesions to form. Postoperative oxidative stress may contribute to…”
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A neurokinin‐1 receptor antagonist (NK‐1RA) that reduces postoperative adhesions inhibits leukocyte recruitment and increases antioxidant capacity in the peritoneal cavity by Reed, Karen L, Heydrick, Stanley J, Prushik, Scott G, Gower, Adam C, Stucchi, Arthur F, Leeman, Susan E, Becker, James M

“…Substance P (SP), a NK‐1R ligand, facilitates leukocyte recruitment and reactive oxygen species (ROS) generation. We have shown in rats that intraperitoneal…”
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Methylene blue reduces intraabdominal adhesions by decreasing peritoneal oxidative stress and increasing peritoneal fibrinolytic activity by Heydrick, Stanley J, Reed, Karen L, Cohen, Philip A, Aarons, Cary B, Gower, Adam C, Stuchi, Arthur F, Becker, James M

“…Intraabdominal adhesions are a major complication of abdominal surgery. Studies in this lab have suggested that peritoneal inflammation and oxidative stress…”
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A neurokinin‐1 receptor antagonist (NK‐1RA) that reduces postoperative adhesions decreases markers of oxidative stress in the peritoneum by Reed, Karen L, Heydrick, Stanley J, Aarons, Cary B, Gower, Adam C, Stucchi, Arthur F, Leeman, Susan E, Becker, James M

“…Postoperative oxidative stress may contribute to peritoneal adhesion formation. Substance P is known to increase reactive oxygen species (ROS) in inflamed…”
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Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice by HEYDRICK, S. J, JULLIEN, D, GAUTIER, N, TANTI, J.-F, GIORGETTI, S, VAN OBBERGHEN, E, LE MARCHAND-BRUSTEL, Y

“…Activation of phosphatidylinositol-3-kinase (PI3K) is one of the earliest postreceptor events in the insulin signaling pathway. Incubation of soleus muscles…”
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Alteration in the expression of GLUT-1 and GLUT-4 protein and messenger RNA levels in denervated rat muscles by Coderre, L, Monfar, M M, Chen, K S, Heydrick, S J, Kurowski, T G, Ruderman, N B, Pilch, P F

“…Denervation induces insulin resistance of the glucose transport process in skeletal muscle. To determine whether this is due to alterations in the expression…”
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Differential effects of okadaic acid on insulin-stimulated glucose and amino acid uptake and phosphatidylinositol 3-kinase activity by Jullien, D, Tanti, J F, Heydrick, S J, Gautier, N, Grémeaux, T, Van Obberghen, E, Le Marchand-Brustel, Y

“…The effect of okadaic acid, a serine/threonine phosphatase inhibitor, was analyzed in two insulin-responsive systems, the isolated mouse soleus muscle and…”
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Effect of IGF-I on phosphatidylinositol 3-kinase in soleus muscle of lean and insulin-resistant obese mice by JULLIEN, D, HEYDRICK, S. J, GAUTIER, N, VAN OBBERGHEN, E, LE MARCHAND-BRUSTEL, Y

“…Insulin and IGF-I induced a similar stimulation of glucose transport in isolated soleus muscle. These actions require phosphatidylinositol (PI) 3-kinase…”
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