Search Results - "Heydrick, Stanley"

Comparison between Patients Hospitalized with Influenza and COVID-19 at a Tertiary Care Center by Donnino, Michael W., Moskowitz, Ari, Thompson, Garrett S., Heydrick, Stanley J., Pawar, Rahul D, Berg, Katherine M., Mehta, Shivani, Patel, Parth V., Grossestreuer, Anne V.

“…Background Widespread reports suggest the characteristics and disease course of coronavirus disease 2019 (COVID-19) and influenza differ, yet detailed…”
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The Effects of Thiamine on Breast Cancer Cells by Liu, Xiaowen, Montissol, Sophia, Uber, Amy, Ganley, Sarah, Grossestreuer, Anne V, Berg, Katherine, Heydrick, Stanley, Donnino, Michael W

“…(1) Background: Thiamine is an important cofactor for multiple metabolic processes. Its role in cancer has been debated for years. Our aim is to determine if…”
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Combined intraoperative administration of a histone deacetylase inhibitor and a neurokinin-1 receptor antagonist synergistically reduces intra-abdominal adhesion formation in a rat model by Cassidy, Michael R., MD, Sherburne, Alan C., MD, Heydrick, Stanley J., PhD, Stucchi, Arthur F., PhD

“…Background Intra-abdominal adhesions are the most frequent postoperative complication after abdominopelvic surgery. Our laboratory has previously shown that an…”
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Substance P is an early mediator of peritoneal fibrinolytic pathway genes and promotes intra-abdominal adhesion formation by Esposito, Anthony J., BA, Heydrick, Stanley J., PhD, Cassidy, Michael R., MD, Gallant, Joseph, MD, Stucchi, Arthur F., PhD, Becker, James M., MD, FACS

“…Abstract Background The substance P (SP) or neurokinin-1 receptor pathway has been implicated in intra-abdominal adhesion formation, in large part through its…”
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N -acetyl- l -cysteine decreases intra-abdominal adhesion formation through the upregulation of peritoneal fibrinolytic activity and antioxidant defenses by Chu, Daniel I., MD, Lim, Rizal, MD, Heydrick, Stanley, PhD, Gainsbury, Melanie L., MD, Abdou, Rami, MA, D’Addese, Laura, BS, Reed, Karen L., PhD, Stucchi, Arthur F., PhD, Becker, James M., MD, FACS

“…Background Intraperitoneal adhesions occur in more than 94% of patients after abdominal surgery. Mechanisms that decrease oxidative stress and upregulate…”
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Psychophysiologic Symptom Relief Therapy for Post-Acute Sequelae of Coronavirus Disease 2019 by Donnino, Michael, Howard, Patricia, Mehta, Shivani, Silverman, Jeremy, Cabrera, Maria J., Yamin, Jolin B., Balaji, Lakshman, Berg, Katherine M., Heydrick, Stanley, Edwards, Robert, Grossestreuer, Anne V.

“…To determine if psychophysiologic symptom relief therapy (PSRT) will reduce symptom burden in patients suffering from post-acute sequelae of coronavirus…”
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Intraperitoneal Administration of Methylene Blue Attenuates Oxidative Stress, Increases Peritoneal Fibrinolysis, and Inhibits Intraabdominal Adhesion Formation by Heydrick, Stanley J., Ph.D, Reed, Karen L., Ph.D, Cohen, Philip A., M.D, Aarons, Cary B., M.D, Gower, Adam C., M.S, Becker, James M., M.D, Stucchi, Arthur F., Ph.D

“…Background Mounting evidence indicates that postoperative oxidative stress may be linked to decreased fibrinolytic activity and, subsequently, the development…”
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Carcinoembryonic antigen-stimulated THP-1 macrophages activate endothelial cells and increase cell-cell adhesion of colorectal cancer cells by Aarons, Cary B, Bajenova, Olga, Andrews, Charles, Heydrick, Stanley, Bushell, Kristen N, Reed, Karen L, Thomas, Peter, Becker, James M, Stucchi, Arthur F

“…The liver is the most common site for metastasis by colorectal cancer, and numerous studies have shown a relationship between serum carcinoembryonic antigen…”
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The neurokinin 1 receptor regulates peritoneal fibrinolytic activity and postoperative adhesion formation by Cassidy, Michael R., MD, Sheldon, Holly K., MD, Gainsbury, Melanie L., MD, Gillespie, Earl, PhD, Kosaka, Hisashi, MD, PhD, Heydrick, Stanley, PhD, Stucchi, Arthur F., PhD

“…Abstract Background Intra-abdominal adhesions are a common source of postoperative morbidity. Previous studies in our laboratory have shown that a neurokinin 1…”
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Overexpression of Cellular Glutathione Peroxidase Rescues Homocyst(e)ine-Induced Endothelial Dysfunction by Weiss, Norbert, Zhang, Ying-Yi, Heydrick, Stanley, Bierl, Charlene, Loscalzo, Joseph

“…Homocyst(e)ine (Hcy) inhibits the expression of the antioxidant enzyme cellular glutathione peroxidase (GPx-1) in vitro and in vivo, which can lead to an…”
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Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia by Eberhardt, R T, Forgione, M A, Cap, A, Leopold, J A, Rudd, M A, Trolliet, M, Heydrick, S, Stark, R, Klings, E S, Moldovan, N I, Yaghoubi, M, Goldschmidt-Clermont, P J, Farber, H W, Cohen, R, Loscalzo, J

“…Homocysteine is a risk factor for the development of atherosclerosis and its thrombotic complications. We have employed an animal model to explore the…”
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Histone deacetylase inhibitors decrease intra-abdominal adhesions with one intraoperative dose by reducing peritoneal fibrin deposition pathways by Cassidy, Michael R., MD, Sherburne, Alan C., MD, Sheldon, Holly K., MD, Gainsbury, Melanie L., MD, Heydrick, Stanley, PhD, Stucchi, Arthur F., PhD

“…Background We previously demonstrated that postoperative peritoneal injury and inflammation contribute to adhesiogenesis. Recent evidence suggests that in…”
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A neurokinin-1 receptor antagonist that reduces intra-abdominal adhesion formation decreases oxidative stress in the peritoneum by Reed, Karen L, Heydrick, Stanley J, Aarons, Cary B, Prushik, Scott, Gower, Adam C, Stucchi, Arthur F, Becker, James M

“…Oxidative stress has been implicated in intra-abdominal adhesion formation. Substance P, a neurokinin-1 receptor (NK-1R) ligand, facilitates leukocyte…”
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Co-Administration of Valproic Acid (VPA), an Histone Deacetylase Inhibitor, and a Neurokinin-1 Receptor Antagonist (NK-1RA) that Reduces Intraabdominal Adhesion Formation in a Rat Surgical Model Downregulates the Expression of the Early Growth Response (Egr) Genes 1 and 3 by Brady, Matthew T., MD, King, Elizabeth G., MD, Keenan, Benjamin, MA, Heydrick, Stanley, PhD, Cassidy, Michael R., MD, Stucchi, Arthur, PhD

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Cellular glutathione peroxidase deficiency and endothelial dysfunction by Forgione, Marc A, Weiss, Norbert, Heydrick, Stanley, Cap, André, Klings, Elizabeth S, Bierl, Charlene, Eberhardt, Robert T, Farber, Harrison W, Loscalzo, Joseph

“…Cellular glutathione peroxidase (GPx-1) is the most abundant intracellular isoform of the GPx antioxidant enzyme family. In this study, we hypothesized that…”
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l-homocysteine and l-homocystine stereospecifically induce endothelial nitric oxide synthase-dependent lipid peroxidation in endothelial cells by Heydrick, Stanley J, Weiss, Norbert, Thomas, Shane R, Cap, Andre P, Pimentel, David R, Loscalzo, Joseph, Keaney, John F

“…Atherothrombotic cardiovascular disease associated with hyperhomocysteinemia has been proposed to result, at least in part, from increased vascular oxidative…”
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Influence of hyperhomocysteinemia on the cellular redox state--impact on homocysteine-induced endothelial dysfunction by Weiss, Norbert, Heydrick, Stanley J, Postea, Otilia, Keller, Christiane, Keaney, Jr, John F, Loscalzo, Joseph

“…Hyperhomocysteinemia is an independent risk factor for the development of atherosclerosis. An increasing body of evidence has implicated oxidative stress as…”
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The angiotensin II receptor blocker (ARB) losartan decreases post-operative intra-abdominal adhesions by modulating the renin-angiotensin system (RAS) and oxidative stress pathways by Gainsbury, Melanie L., MD, Sheldon, Holly K., MD, Cassidy, Michael R., MD, Heydrick, Stanley, PhD, Mitra, Somdutta, MS, Stucchi, Arthur F., PhD, Becker, James M., MD, FACS

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Nitric Oxide Inhibits Thrombin Receptor-activating Peptide-induced Phosphoinositide 3-Kinase Activity in Human Platelets by Pigazzi, Alessio, Heydrick, Stanley, Folli, Franco, Benoit, Stephen, Michelson, Alan, Loscalzo, Joseph

“…Although nitric oxide (NO) has potent antiplatelet actions, the signaling pathways affected by NO in the platelet are poorly understood. Since NO can induce…”
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N-acetyl- l -cysteine (NAC) reduces intraabdominal adhesion formation through the upregulation of peritoneal fibrinolytic activity and antioxidant defenses by Chu, Daniel I., MD, Lim, Rizal, MD, Heydrick, Stanley, PhD, Reed, Karen L., PhD, Stucchi, Arthur F., PhD, Becker, James M., MD, FACS

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