Search Results - "Heyderman, R S"

Determinants of high residual post-PCV13 pneumococcal vaccine-type carriage in Blantyre, Malawi: a modelling study by Lourenço, J, Obolski, U, Swarthout, T D, Gori, A, Bar-Zeev, N, Everett, D, Kamng'ona, A W, Mwalukomo, T S, Mataya, A A, Mwansambo, C, Banda, M, Gupta, S, French, N, Heyderman, R S

“…In November 2011, Malawi introduced the 13-valent pneumococcal conjugate vaccine (PCV13) into the routine infant schedule. Four to 7 years after introduction…”
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Methodological challenges in measuring vaccine effectiveness using population cohorts in low resource settings by King, C, Beard, J, Crampin, A.C, Costello, A, Mwansambo, C, Cunliffe, N.A, Heyderman, R.S, French, N, Bar-Zeev, N

“…Highlights • We discuss methodological challenges for evaluating vaccine effectiveness using cohorts. • No single set of definitions or analytical approach can…”
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Circulating platelet–neutrophil complexes represent a subpopulation of activated neutrophils primed for adhesion, phagocytosis and intracellular killing by Peters, M. J., Dixon, G., Kotowicz, K. T., Hatch, D. J., Heyderman, R. S., Klein, N. J.

“…Platelets play a prominent role in linking the processes of inflammation, haemostasis and thrombosis. Recent studies have shown that platelets form heterotypic…”
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HIV‐exposed uninfected children: a growing population with a vulnerable immune system? by Afran, L., Garcia Knight, M., Nduati, E., Urban, B. C., Heyderman, R. S., Rowland‐Jones, S. L.

“…Summary Through the successful implementation of policies to prevent mother‐to‐child‐transmission (PMTCT) of HIV‐1 infection, children born to HIV‐1‐infected…”
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Early management of suspected bacterial meningitis and meningococcal septicaemia in immunocompetent adults—second edition by Heyderman, R.S.

“…Bacterial meningitis and meningococcal septicaemia continue to cause death and disability in adults. This updated algorithm focuses on minimising delays in…”
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Analysis of Pathogen-Host Cell Interactions in Purpura Fulminans: Expression of Capsule, Type IV Pili, and PorA by Neisseria meningitidis In Vivo by HARRISON, O. B, ROBERTSON, B. D, FAUST, S. N, JEPSON, M. A, GOLDIN, R. D, LEVIN, M, HEYDERMAN, R. S

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Small alveolar macrophages are infected preferentially by HIV and exhibit impaired phagocytic function by Jambo, K C, Banda, D H, Kankwatira, A M, Sukumar, N, Allain, T J, Heyderman, R S, Russell, D G, Mwandumba, H C

“…HIV-1-infected persons are at higher risk of lower respiratory tract infections than HIV-1-uninfected individuals. This suggests strongly that HIV-infected…”
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The incidence and mortality for meningococcal disease associated with area deprivation: an ecological study of hospital episode statistics by Heyderman, R S, Ben-Shlomo, Y, Brennan, C A, Somerset, M

“…Aims: To determine whether incidence, mortality, and case fatality for meningococcal disease (MD) differs by area deprivation, and if this has changed over…”
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The UK joint specialist societies guideline on the diagnosis and management of acute meningitis and meningococcal sepsis in immunocompetent adults by McGill, F, Heyderman, R.S, Michael, B.D, Defres, S, Beeching, N.J, Borrow, R, Glennie, L, Gaillemin, O, Wyncoll, D, Kaczmarski, E, Nadel, S, Thwaites, G, Cohen, J, Davies, N.W.S, Miller, A, Rhodes, A, Read, R, Solomon, T

“…Summary Bacterial meningitis and meningococcal sepsis are rare conditions with high case fatality rates. Early recognition and prompt treatment saves lives. In…”
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Impact of HIV infection on meningitis in Harare, Zimbabwe : a prospective study of 406 predominantly adult patients by HAKIM, J. G, GANGAIDZO, I. T, HEYDERMAN, R. S, MIELKE, J, MUSHANGI, E, TAZIWA, A, ROBERTSON, V. J, MUSVAIRE, P, MASON, P. R

“…To determine the causative organisms and characteristics of patients presenting with features of meningitis. A prospective cross-sectional study. Two tertiary…”
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British Infection Association guidelines for the diagnosis and management of enteric fever in England by Nabarro, L.E., McCann, N., Herdman, M.T., Dugan, C., Ladhani, S., Patel, D., Morris-Jones, S., Balasegaram, S., Heyderman, R.S., Brown, M., Parry, C.M., Godbole, G.

“…•First clinical guidelines for management of enteric fever in England.•Majority of cases are imported infections from South Asia.•Blood cultures remain the…”
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Changing epidemiology of bacterial meningitis among adults in England and Wales 1991–2002 by GJINI, A. B., STUART, J. M., LAWLOR, D. A., CARTWRIGHT, K. A. V., CHRISTENSEN, H., RAMSAY, M., HEYDERMAN, R. S.

“…We examined the epidemiology of community-acquired bacterial meningitis among adults in England and Wales between 1991 and 2002. Among 3169 cases,…”
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Influence of age and carriage status on salivary IgA to Neisseria meningitidis by HORTON, R. E., STUART, J., CHRISTENSEN, H., BORROW, R., GUTHRIE, T., DAVENPORT, V., FINN, A., The ALSPAC Study Team, WILLIAMS, N. A., HEYDERMAN, R. S.

“…Asymptomatic carriage of Neisseria meningitidis is common (5–35% of individuals) while the incidence of invasive meningococcal disease is fairly low (<1–5 per…”
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Coagulation in severe sepsis: A central role for thrombomodulin and activated protein C by Faust, Saul N, Heyderman, Robert S, Levin, Michael

“…OBJECTIVESTo review the mechanisms that cause coagulation abnormalities in sepsis, focusing on the interaction between the vascular endothelium and the…”
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Determination of a Viral Load Threshold To Distinguish Symptomatic versus Asymptomatic Rotavirus Infection in a High-Disease-Burden African Population by Bennett, A, Bar-Zeev, N, Jere, K C, Tate, J E, Parashar, U D, Nakagomi, O, Heyderman, R S, French, N, Iturriza-Gomara, M, Cunliffe, N A

“…We evaluated quantitative real-time PCR to establish the diagnosis of rotavirus gastroenteritis in a high-disease-burden population in Malawi using enzyme…”
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Early Management of Suspected Bacterial Meningitis and Meningococcal Septicaemia in Adults by Heyderman, R.S., Lambert, H.P., O'Sullivan, I., Stuart, J.M., Taylor, B.L., Wall, R.A.

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Direct and possible indirect effects of vaccination on rotavirus hospitalisations among children in Malawi four years after programmatic introduction by Bennett, A., Pollock, L., Jere, K.C., Pitzer, V.E., Parashar, U., Tate, J.E., Heyderman, R.S., Mwansambo, C., French, N., Nakagomi, O., Iturriza-Gomara, M., Everett, D., Cunliffe, N.A., Bar-Zeev, N.

“…Despite increased use of vaccine in routine immunisation, rotavirus remains a major cause of acute gastroenteritis (AGE) in low-income countries. We describe…”
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Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding by Moxon, C. A., Chisala, N. V., Mzikamanda, R., MacCormick, I., Harding, S., Downey, C., Molyneux, M., Seydel, K. B., Taylor, T. E., Heyderman, R. S., Toh, C.‐H.

“…Summary Background A procoagulant state is implicated in cerebral malaria (CM) pathogenesis, but whether disseminated intravascular coagulation (DIC) is…”
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Human papillomavirus and head and neck cancer: a systematic review and meta-analysis by Hobbs, C.G.L., Sterne, J.A.C., Bailey, M., Heyderman, R.S., Birchall, M.A., Thomas, S.J.

“…Keypoints •It has been suggested that the link between human papillomavirus (HPV) and head and neck squamous cell carcinoma (HNSCC) is specific to carcinoma of…”
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High‐level endothelial E‐selectin (CD62E) cell adhesion molecule expression by a lipopolysaccharide‐deficient strain of Neisseria meningitidis despite poor activation of NF‐κB transcription factor by DIXON, G. L. J., HEYDERMAN, R. S., VAN DER LEY, P., KLEIN, N. J.

“…SUMMARY Binding of host inflammatory cells to the endothelium is a critical contributor to the vascular damage characteristic of severe meningococcal disease…”
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