Search Results - "Heydemann, Ahlke"

An Overview of Murine High Fat Diet as a Model for Type 2 Diabetes Mellitus by Heydemann, Ahlke

“…Type 2 diabetes mellitus (T2DM) is a worldwide epidemic, which by all predictions will only increase. To help in combating the devastating array of phenotypes…”
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Skeletal Muscle Metabolism in Duchenne and Becker Muscular Dystrophy-Implications for Therapies by Heydemann, Ahlke

“…The interactions between nutrition and metabolism and skeletal muscle have long been known. Muscle is the major metabolic organ-it consumes more calories than…”
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The super super-healing MRL mouse strain by Heydemann, Ahlke

“…The Murphy Roths Large （MRL/MpJ） mice provide unique insights into wound repair and regeneration. These mice and the closely related MRL/MpJ-Fas Ipr/J and…”
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A Brief Review of Duchenne Muscular Dystrophy Treatment Options, with an Emphasis on Two Novel Strategies by Heydemann, Ahlke, Siemionow, Maria

“…Despite the full cloning of the Dystrophin cDNA 35 years ago, no effective treatment exists for the Duchenne Muscular Dystrophy (DMD) patients who have a…”
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Long-Term Biodistribution and Safety of Human Dystrophin Expressing Chimeric Cell Therapy After Systemic-Intraosseous Administration to Duchenne Muscular Dystrophy Model by Siemionow, Maria, Brodowska, Sonia, Langa, Paulina, Zalants, Kristina, Kozlowska, Katarzyna, Grau-Kazmierczak, Wictoria, Heydemann, Ahlke

“…Duchenne muscular dystrophy (DMD) is a lethal disease caused by X-linked mutations in the dystrophin gene. Dystrophin deficiency results in progressive…”
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Human dystrophin expressing chimeric (DEC) cell therapy ameliorates cardiac, respiratory, and skeletal muscle's function in Duchenne muscular dystrophy by Siemionow, Maria, Langa, Paulina, Harasymczuk, Michal, Cwykiel, Joanna, Sielewicz, Magdalena, Smieszek, Jaroslaw, Heydemann, Ahlke

“…Duchenne muscular dystrophy (DMD) is a progressive and lethal disease, caused by X‐linked mutations of the dystrophin encoding gene. The lack of dystrophin…”
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Annexin A6 modifies muscular dystrophy by mediating sarcolemmal repair by Swaggart, Kayleigh A., Demonbreun, Alexis R., Vo, Andy H., Swanson, Kaitlin E., Kim, Ellis Y., Fahrenbach, John P., Holley-Cuthrell, Jenan, Eskin, Ascia, Chen, Zugen, Squire, Kevin, Heydemann, Ahlke, Palmer, Abraham A., Nelson, Stanley F., McNally, Elizabeth M.

“…Many monogenic disorders, including the muscular dystrophies, display phenotypic variability despite the same disease-causing mutation. To identify genetic…”
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The MRL Mitochondrial Genome Decreases Murine Muscular Dystrophy Severity by Holley-Cuthrell, Jenan, Iqbal, Aqsa, Heydemann, Ahlke

“…It is well known that muscular dystrophy disease severity is controlled by genetic modifiers. The expectation is that by identifying these modifiers, we can…”
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Assessment of Motor Unit Potentials Duration as the Biomarker of DT-DEC01 Cell Therapy Efficacy in Duchenne Muscular Dystrophy Patients up to 12 Months After Systemic–Intraosseous Administration by Niezgoda, Adam, Biegański, Grzegorz, Wachowiak, Jacek, Czarnota, Jarosław, Siemionow, Krzysztof, Heydemann, Ahlke, Ziemiecka, Anna, Sikorska, Maria H., Bożyk, Katarzyna, Siemionow, Maria

“…Duchenne muscular dystrophy (DMD) is a lethal X-linked disease caused by mutations in the dystrophin gene, leading to muscle degeneration and wasting…”
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Amelioration of Morphological Pathology in Cardiac, Respiratory, and Skeletal Muscles Following Intraosseous Administration of Human Dystrophin Expressing Chimeric (DEC) Cells in Duchenne Muscular Dystrophy Model by Siemionow, Maria, Budzynska, Katarzyna, Zalants, Kristina, Langa, Paulina, Brodowska, Sonia, Siemionow, Krzysztof, Heydemann, Ahlke

“…Duchenne Muscular Dystrophy (DMD) is a lethal disease caused by mutation in the dystrophin gene. Currently there is no cure for DMD. We introduced a novel…”
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Systemically Administered Homing Peptide Targets Dystrophic Lesions and Delivers Transforming Growth Factor-β (TGFβ) Inhibitor to Attenuate Murine Muscular Dystrophy Pathology by Iqbal, Aqsa, May, Ulrike, Prince, Stuart N., Järvinen, Tero A.H., Heydemann, Ahlke

“…Muscular dystrophy is a progressively worsening and lethal disease, where accumulation of functionality-impairing fibrosis plays a key pathogenic role…”
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S100A12 Mediates Aortic Wall Remodeling and Aortic Aneurysm by Bowman, Marion Hofmann, Wilk, Jeannine, Heydemann, Ahlke, Kim, Gene, Rehman, Jalees, Lodato, Joseph A, Raman, Jai, McNally, Elizabeth M

“…RATIONALE:S100A12 is a small calcium binding protein that is a ligand of RAGE (receptor for advanced glycation end products). RAGE has been extensively…”
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Intraosseous transplant of dystrophin expressing chimeric (DEC) cells improves skeletal muscle function in mdx mouse model of Duchenne muscular dystrophy by Malik, Mohammad, Siemionow, Maria, Cwykiel, Joanna, Heydemann, Ahlke, Garcia-Martinez, Jesus, Siemionow, Krzysztof, Szilagyi, Erzsebet

“…We previously reported that systemic delivery of dystrophin expressing chimeric (DEC) cells of normal ( ) and dystrophin-deficient ( ) myoblast (MB) or…”
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Consequences of Disrupting the Dystrophin-Sarcoglycan Complex in Cardiac and Skeletal Myopathy by Heydemann, Ahlke, McNally, Elizabeth M

“…Mutations that disrupt the dystrophin glycoprotein complex lead to plasma membrane instability of cardiomyocytes and skeletal muscle myofibers. Instability of…”
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"Of Mice and Measures": A Project to Improve How We Advance Duchenne Muscular Dystrophy Therapies to the Clinic by Gordish-Dressman, Heather, Willmann, Raffaella, Dalle Pazze, Laura, Kreibich, Arati, van Putten, Maaike, Heydemann, Ahlke, Bogdanik, Laurent, Lutz, Cathleen, Davies, Kay, Demonbreun, Alexis R, Duan, Dongsheng, Elsey, David, Fukada, So-Ichiro, Girgenrath, Mahasweta, Patrick Gonzalez, J, Grounds, Miranda D, Nichols, Andy, Partridge, Terry, Passini, Marco, Sanarica, Francesca, Schnell, Frederick J, Wells, Dominic J, Yokota, Toshifumi, Young, Courtney S, Zhong, Zhong, Spurney, Christopher, Spencer, Melissa, De Luca, Annamaria, Nagaraju, Kanneboyina, Aartsma-Rus, Annemieke

“…A new line of dystrophic mdx mice on the DBA/2J (D2) background has emerged as a candidate to study the efficacy of therapeutic approaches for Duchenne…”
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Severe murine limb‐girdle muscular dystrophy type 2C pathology is diminished by FTY720 treatment by Heydemann, Ahlke

“…ABSTRACT Introduction Limb‐girdle muscular dystrophy type 2C (LGMD‐2C) is caused by mutations in γ‐sarcoglycan and is a devastating, progressive, and fully…”
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The superhealing MRL background improves muscular dystrophy by Heydemann, Ahlke, Swaggart, Kayleigh A, Kim, Gene H, Holley-Cuthrell, Jenan, Hadhazy, Michele, McNally, Elizabeth M

“…Mice from the MRL or "superhealing" strain have enhanced repair after acute injury to the skin, cornea, and heart. We now tested an admixture of the MRL genome…”
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Smooth muscle cell-extrinsic vascular spasm arises from cardiomyocyte degeneration in sarcoglycan-deficient cardiomyopathy by Wheeler, Matthew T, Allikian, Michael J, Heydemann, Ahlke, Hadhazy, Michele, Zarnegar, Sara, McNally, Elizabeth M

“…Vascular spasm is a poorly understood but critical biomedical process because it can acutely reduce blood supply and tissue oxygenation. Cardiomyopathy in mice…”
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Genetic background influences muscular dystrophy by Heydemann, Ahlke, Huber, Jill M., Demonbreun, Alexis, Hadhazy, Michele, McNally, Elizabeth M.

“…Mutations in the genes encoding dystrophin and its associated proteins, the sarcoglycans, lead to muscular dystrophy in humans and in mouse models. In the…”
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TGF-β1 Prevents Hypertrophy of Epiphyseal Chondrocytes: Regulation of Gene Expression for Cartilage Matrix Proteins and Metalloproteases by Ballock, R.Tracy, Heydemann, Ahlke, Wakefield, Lalage M., Flanders, Kathleen C., Roberts, Anita B., Sporn, Michael B.

“…Using an in vitro model of rat epiphyseal chrondrocyte differentiation in which cells are maintained in a three-dimensional cell pellet, we show that exogenous…”
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