Search Results - "Heycock, Morgan W. D."
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RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus
Published in Nature immunology (01-02-2021)“…Type 2 innate lymphoid cells (ILC2) contribute to immune homeostasis, protective immunity and tissue repair. Here we demonstrate that functional ILC2 cells can…”
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An αvβ3 integrin checkpoint is critical for efficient TH2 cell cytokine polarization and potentiation of antigen-specific immunity
Published in Nature immunology (01-01-2023)“…Naive CD4 + T lymphocytes initially undergo antigen-specific activation to promote a broad-spectrum response before adopting bespoke cytokine expression…”
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Group-2 innate lymphoid cell-dependent regulation of tissue neutrophil migration by alternatively activated macrophage-secreted Ear11
Published in Mucosal immunology (01-01-2021)“…Type-2 immunity is characterised by interleukin (IL)-4, IL-5 and IL-13, eosinophilia, mucus production, IgE, and alternatively activated macrophages (AAM)…”
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Identification of aceNKPs, a committed common progenitor population of the ILC1 and NK cell continuum
Published in Proceedings of the National Academy of Sciences - PNAS (06-12-2022)“…The development of innate lymphoid cell (ILC) transcription factor reporter mice has shown a previously unexpected complexity in ILC hematopoiesis. Using novel…”
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5
An αvβ3 integrin checkpoint is critical for efficient TH2 cytokine polarisation and potentiating antigen-specific immunity
Published in Nature immunology (22-12-2022)“…Naïve CD4 + T lymphocytes initially undergo antigen-specific activation to promote a broad-spectrum response before adopting bespoke cytokine expression…”
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Journal Article -
6
ROR[alpha] is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus
Published in Nature immunology (01-02-2021)“…Type 2 innate lymphoid cells (ILC2) contribute to immune homeostasis, protective immunity and tissue repair. Here we demonstrate that functional ILC2 cells can…”
Get full text
Journal Article -
7
An αvβ3 integrin checkpoint is critical for efficient T H 2 cell cytokine polarization and potentiation of antigen-specific immunity
Published in Nature immunology (01-01-2023)“…Naive CD4 T lymphocytes initially undergo antigen-specific activation to promote a broad-spectrum response before adopting bespoke cytokine expression profiles…”
Get full text
Journal Article