Search Results - "Heybrock, Saskia"

Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export by Heybrock, Saskia, Kanerva, Kristiina, Meng, Ying, Ing, Chris, Liang, Anna, Xiong, Zi-Jian, Weng, Xialian, Ah Kim, Young, Collins, Richard, Trimble, William, Pomès, Régis, Privé, Gilbert G., Annaert, Wim, Schwake, Michael, Heeren, Joerg, Lüllmann-Rauch, Renate, Grinstein, Sergio, Ikonen, Elina, Saftig, Paul, Neculai, Dante

“…The intracellular transport of cholesterol is subject to tight regulation. The structure of the lysosomal integral membrane protein type 2 (LIMP-2, also known…”
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Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies by Conrad, Karen S., Cheng, Ting-Wen, Ysselstein, Daniel, Heybrock, Saskia, Hoth, Lise R., Chrunyk, Boris A., am Ende, Christopher W., Krainc, Dimitri, Schwake, Michael, Saftig, Paul, Liu, Shenping, Qiu, Xiayang, Ehlers, Michael D.

“…Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) contributes to endosomal and lysosomal function. LIMP-2 deficiency is associated with neurological…”
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Cholesterol Handling in Lysosomes and Beyond by Meng, Ying, Heybrock, Saskia, Neculai, Dante, Saftig, Paul

“…Lysosomes are of major importance for the regulation of cellular cholesterol homeostasis. Food-derived cholesterol and cholesterol esters contained within…”
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S-palmitoylation determines TMEM55B-dependent positioning of lysosomes by Rudnik, Sönke, Heybrock, Saskia, Saftig, Paul, Damme, Markus

“…The spatiotemporal cellular distribution of lysosomes depends on active transport mainly driven by microtubule motors such as kinesins and dynein. Different…”
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Lysosome-targeted multifunctional lipid probes reveal the sterol transporter NPC1 as a sphingosine interactor by Altuzar, Janathan, Notbohm, Judith, Stein, Frank, Haberkant, Per, Hempelmann, Pia, Heybrock, Saskia, Worsch, Jutta, Saftig, Paul, Höglinger, Doris

“…Lysosomes are catabolic organelles involved in macromolecular digestion, and their dysfunction is associated with pathologies ranging from lysosomal storage…”
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The lysosomal lipid transporter LIMP-2/SCARB2 is part of lysosome-endoplasmic reticulum STARD3-VAPB-dependent contact sites by Rudnik, Sönke, Heybrock, Saskia, Coyaud, Etienne, Xu, Zizhen, Neculai, Dante, Raught, Brian, Oorschot, Viola, Heus, Cecilia, Klumperman, Judith, Saftig, Paul

“…SCARB2/LIMP-2 is an abundant lysosomal membrane protein. Previous studies have shown LIMP-2 functions as a virus receptor, a chaperone for lysosomal enzyme…”
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