Search Results - "Hewitt, L"

Randomized Withdrawal Study of Patients With Symptomatic Neurogenic Orthostatic Hypotension Responsive to Droxidopa by Biaggioni, Italo, Freeman, Roy, Mathias, Christopher J, Low, Phillip, Hewitt, L Arthur, Kaufmann, Horacio

“…ABSTRACT—We evaluated whether droxidopa, a prodrug converted to norepinephrine, is beneficial in the treatment of symptomatic neurogenic orthostatic…”
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Effect-directed analysis supporting monitoring of aquatic environments — An in-depth overview by Brack, Werner, Ait-Aissa, Selim, Burgess, Robert M., Busch, Wibke, Creusot, Nicolas, Di Paolo, Carolina, Escher, Beate I., Mark Hewitt, L., Hilscherova, Klara, Hollender, Juliane, Hollert, Henner, Jonker, Willem, Kool, Jeroen, Lamoree, Marja, Muschket, Matthias, Neumann, Steffen, Rostkowski, Pawel, Ruttkies, Christoph, Schollee, Jennifer, Schymanski, Emma L., Schulze, Tobias, Seiler, Thomas-Benjamin, Tindall, Andrew J., De Aragão Umbuzeiro, Gisela, Vrana, Branislav, Krauss, Martin

“…Aquatic environments are often contaminated with complex mixtures of chemicals that may pose a risk to ecosystems and human health. This contamination cannot…”
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Integrated analysis of droxidopa trials for neurogenic orthostatic hypotension by Biaggioni, Italo, Arthur Hewitt, L, Rowse, Gerald J, Kaufmann, Horacio

“…Droxidopa, a prodrug of norepinephrine, was approved for treatment of neurogenic orthostatic hypotension (nOH) due to primary autonomic disorders based on 3…”
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Suicide behaviors during the COVID-19 pandemic: A meta-analysis of 54 studies by Dubé, Justin P., Smith, Martin M., Sherry, Simon B., Hewitt, Paul L., Stewart, Sherry H.

“…•Meta-analyzed research on suicide behaviors during the COVID-19 pandemic.•Identified 54 relevant studies involving 308,596 participants.•Rates were high for…”
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Towards the review of the European Union Water Framework Directive: Recommendations for more efficient assessment and management of chemical contamination in European surface water resources by Brack, Werner, Dulio, Valeria, Ågerstrand, Marlene, Allan, Ian, Altenburger, Rolf, Brinkmann, Markus, Bunke, Dirk, Burgess, Robert M., Cousins, Ian, Escher, Beate I., Hernández, Félix J., Hewitt, L. Mark, Hilscherová, Klára, Hollender, Juliane, Hollert, Henner, Kase, Robert, Klauer, Bernd, Lindim, Claudia, Herráez, David López, Miège, Cécil, Munthe, John, O'Toole, Simon, Posthuma, Leo, Rüdel, Heinz, Schäfer, Ralf B., Sengl, Manfred, Smedes, Foppe, van de Meent, Dik, van den Brink, Paul J., van Gils, Jos, van Wezel, Annemarie P., Vethaak, A. Dick, Vermeirssen, Etienne, von der Ohe, Peter C., Vrana, Branislav

“…Water is a vital resource for natural ecosystems and human life, and assuring a high quality of water and protecting it from chemical contamination is a major…”
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Droxidopa for neurogenic orthostatic hypotension: A randomized, placebo-controlled, phase 3 trial by Kaufmann, Horacio, Freeman, Roy, Biaggioni, Italo, Low, Phillip, Pedder, Simon, Hewitt, L Arthur, Mauney, Joe, Feirtag, Michael, Mathias, Christopher J

“…OBJECTIVE:To determine whether droxidopa, an oral norepinephrine precursor, improves symptomatic neurogenic orthostatic hypotension (nOH). METHODS:Patients…”
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Future water quality monitoring: improving the balance between exposure and toxicity assessments of real-world pollutant mixtures by Altenburger, Rolf, Brack, Werner, Burgess, Robert M., Busch, Wibke, Escher, Beate I., Focks, Andreas, Mark Hewitt, L., Jacobsen, Bo N., de Alda, Miren López, Ait-Aissa, Selim, Backhaus, Thomas, Ginebreda, Antoni, Hilscherová, Klára, Hollender, Juliane, Hollert, Henner, Neale, Peta A., Schulze, Tobias, Schymanski, Emma L., Teodorovic, Ivana, Tindall, Andrew J., de Aragão Umbuzeiro, Gisela, Vrana, Branislav, Zonja, Bozo, Krauss, Martin

“…Environmental water quality monitoring aims to provide the data required for safeguarding the environment against adverse biological effects from multiple…”
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The perniciousness of perfectionism: A meta‐analytic review of the perfectionism–suicide relationship by Smith, Martin M., Sherry, Simon B., Chen, Samantha, Saklofske, Donald H., Mushquash, Christopher, Flett, Gordon L., Hewitt, Paul L.

“…Objective Over 50 years of research implicates perfectionism in suicide. Yet the role of perfectionism in suicide needs clarification due to notable…”
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Droxidopa for the Short-Term Treatment of Symptomatic Neurogenic Orthostatic Hypotension in Parkinson's Disease (nOH306B) by Hauser, Robert A., Isaacson, Stuart, Lisk, Jerome P., Hewitt, L. Arthur, Rowse, Gerry

“…ABSTRACT Neurogenic orthostatic hypotension (nOH) results from failure of norepinephrine responses to postural change to maintain standing systolic blood…”
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Intratumoral IL12 mRNA Therapy Promotes TH1 Transformation of the Tumor Microenvironment by Hewitt, Susannah L, Bailey, Dyane, Zielinski, John, Apte, Ameya, Musenge, Faith, Karp, Russell, Burke, Shannon, Garcon, Fabien, Mishra, Ankita, Gurumurthy, Sushma, Watkins, Amanda, Arnold, Kristen, Moynihan, James, Clancy-Thompson, Eleanor, Mulgrew, Kathy, Adjei, Grace, Deschler, Katharina, Potz, Darren, Moody, Gordon, Leinster, David A, Novick, Steve, Sulikowski, Michal, Bagnall, Chris, Martin, Philip, Lapointe, Jean-Martin, Si, Han, Morehouse, Chris, Sedic, Maja, Wilkinson, Robert W, Herbst, Ronald, Frederick, Joshua P, Luheshi, Nadia

“…While immune checkpoint inhibitors such as anti-PD-L1 are rapidly becoming the standard of care in the treatment of many cancers, only a subset of treated…”
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Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration by Loreto, Andrea, Hill, Ciaran S., Hewitt, Victoria L., Orsomando, Giuseppe, Angeletti, Carlo, Gilley, Jonathan, Lucci, Cristiano, Sanchez-Martinez, Alvaro, Whitworth, Alexander J., Conforti, Laura, Dajas-Bailador, Federico, Coleman, Michael P.

“…Wallerian degeneration of physically injured axons involves a well-defined molecular pathway linking loss of axonal survival factor NMNAT2 to activation of…”
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Steroidal Aromatic ‘Naphthenic Acids’ in Oil Sands Process-Affected Water: Structural Comparisons with Environmental Estrogens by Rowland, Steven J, West, Charles E, Jones, David, Scarlett, Alan G, Frank, Richard A, Hewitt, L. Mark

“…The large volumes, acute toxicity, estrogenicity, and antiandrogenicity of process-affected waters accruing in tailings ponds from the operations of the…”
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Molecular architecture of the active mitochondrial protein gate by Shiota, Takuya, Imai, Kenichiro, Qiu, Jian, Hewitt, Victoria L., Tan, Khershing, Shen, Hsin-Hui, Sakiyama, Noriyuki, Fukasawa, Yoshinori, Hayat, Sikander, Kamiya, Megumi, Elofsson, Arne, Tomii, Kentaro, Horton, Paul, Wiedemann, Nils, Pfanner, Nikolaus, Lithgow, Trevor, Endo, Toshiya

“…Mitochondria fulfill central functions in cellular energetics, metabolism, and signaling. The outer membrane translocator complex (the TOM complex) imports…”
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Sex‐Related Embryotoxicity of Pulp Mill Effluent Extracts in Medaka (Oryzias latipes) Female Leucophore‐free FLFII Strain by Orrego, Rodrigo, Guchardi, John, Beyger, Lindsay, Barra, Ricardo, Hewitt, L. Mark, Holdway, Douglas

“…The aim of the present study was to evaluate the effects of exposure to Chilean pulp mill effluent extracts on developing postfertilized medaka embryos before…”
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Glyoxylic acid overcomes 1-MCP-induced blockage of fruit ripening in Pyrus communis L. var. ‘D’Anjou by Hewitt, Seanna L., Ghogare, Rishikesh, Dhingra, Amit

“…1-methylcyclopropene (1-MCP) in an ethylene receptor antagonist that blocks ethylene perception and downstream ripening responses in climacteric fruit…”
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Classification of non-indigenous species based on their impacts: considerations for application in marine management by Ojaveer, Henn, Galil, Bella S, Campbell, Marnie L, Carlton, James T, Canning-Clode, João, Cook, Elizabeth J, Davidson, Alisha D, Hewitt, Chad L, Jelmert, Anders, Marchini, Agnese, McKenzie, Cynthia H, Minchin, Dan, Occhipinti-Ambrogi, Anna, Olenin, Sergej, Ruiz, Gregory

“…Assessment of the ecological and economic/societal impacts of the introduction of non-indigenous species (NIS) is one of the primary focus areas of bioinvasion…”
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Compartment-specific tuning of dendritic feature selectivity by intracellular Ca2+ release by Justin K O’Hare, Gonzalez, Kevin C, Herrlinger, Stephanie A, Hirabayashi, Yusuke, Hewitt, Victoria L, Blockus, Heike, Szoboszlay, Miklos, Rolotti, Sebi V, Geiller, Tristan C, Negrean, Adrian, Chelur, Vikas, Polleux, Franck, Losonczy, Attila

“…Calcium release and neuronal plasticityWhat is the role of intracellular calcium release from the endoplasmatic reticulum in neuronal signal processing and in…”
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Acute toxicity of aromatic and non-aromatic fractions of naphthenic acids extracted from oil sands process-affected water to larval zebrafish by Scarlett, A.G., Reinardy, H.C., Henry, T.B., West, C.E., Frank, R.A., Hewitt, L.M., Rowland, S.J.

“…•Toxicity of oil sands process water extract to fish determined (LC50 ∼8mgL−1).•Toxicity of esterifiable free naphthenic acids determined (LC50…”
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Predictive and feedback performance errors are signaled in the simple spike discharge of individual Purkinje cells by Popa, Laurentiu S, Hewitt, Angela L, Ebner, Timothy J

“…The cerebellum has been implicated in processing motor errors required for on-line control of movement and motor learning. The dominant view is that Purkinje…”
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Polycyclic aromatic compounds in the Canadian Environment: Aquatic and terrestrial environments by Marvin, Christopher H., Berthiaume, Alicia, Burniston, Deborah A., Chibwe, Leah, Dove, Alice, Evans, Marlene, Hewitt, L. Mark, Hodson, Peter V., Muir, Derek C.G., Parrott, Joanne, Thomas, Philippe J., Tomy, Gregg T.

“…Polycyclic aromatic compounds (PACs) are ubiquitous across environmental media in Canada, including surface water, soil, sediment and snowpack. Information is…”
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