Search Results - "Hewitt, Alex"

Dr AI will see you now by Hewitt, Alex W.

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Current state and future prospects of artificial intelligence in ophthalmology: a review by Hogarty, Daniel T, Mackey, David A, Hewitt, Alex W

“…Artificial intelligence (AI) has emerged as a major frontier in computer science research. Although AI has broad application across many medical fields, it…”
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propeller: testing for differences in cell type proportions in single cell data by Phipson, Belinda, Sim, Choon Boon, Porrello, Enzo R, Hewitt, Alex W, Powell, Joseph, Oshlack, Alicia

“…Abstract Motivation Single cell RNA-Sequencing (scRNA-seq) has rapidly gained popularity over the last few years for profiling the transcriptomes of thousands…”
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Single-cell eQTL mapping identifies cell type-specific genetic control of autoimmune disease by Yazar, Seyhan, Alquicira-Hernandez, Jose, Wing, Kristof, Senabouth, Anne, Gordon, M Grace, Andersen, Stacey, Lu, Qinyi, Rowson, Antonia, Taylor, Thomas R P, Clarke, Linda, Maccora, Katia, Chen, Christine, Cook, Anthony L, Ye, Chun Jimmie, Fairfax, Kirsten A, Hewitt, Alex W, Powell, Joseph E

“…The human immune system displays substantial variation between individuals, leading to differences in susceptibility to autoimmune disease. We present…”
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Predicting the Future of Genetic Risk Profiling of Glaucoma: A Narrative Review by Han, Xikun, Hewitt, Alex W, MacGregor, Stuart

“…Glaucoma is the world's leading cause of irreversible blindness. Primary open-angle glaucoma (POAG) is typically asymptomatic early in the disease process, and…”
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Smartphone use in ophthalmology: What is their place in clinical practice? by Hogarty, Daniel T., Hogarty, Joseph P., Hewitt, Alex W.

“…Smartphones are an increasingly common and rapidly developing tool in clinical practice. Numerous applications or “apps” are available for use on smartphones…”
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Genetic risk of glaucoma is associated with vascular and retinal nerve fibre wedge defects by Saks, Danit G., Schulz, Angela, Qassim, Ayub, Marshall, Henry, Hewitt, Alex W., MacGregor, Stuart, Craig, Jamie E., Graham, Stuart L.

“…Purpose To evaluate the association between localised vascular and retinal nerve fibre layer (RNFL) loss and genetic risk for glaucoma and cardiovascular…”
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Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia by Hysi, Pirro G., Choquet, Hélène, Khawaja, Anthony P., Wojciechowski, Robert, Tedja, Milly S., Yin, Jie, Simcoe, Mark J., Patasova, Karina, Mahroo, Omar A., Thai, Khanh K., Cumberland, Phillippa M., Melles, Ronald B., Verhoeven, Virginie J. M., Vitart, Veronique, Segre, Ayellet, Stone, Richard A., Wareham, Nick, Hewitt, Alex W., Mackey, David A., Klaver, Caroline C. W., MacGregor, Stuart, Khaw, Peng T., Foster, Paul J., Guggenheim, Jeremy A., Rahi, Jugnoo S., Jorgenson, Eric, Hammond, Christopher J.

“…Refractive errors, in particular myopia, are a leading cause of morbidity and disability worldwide. Genetic investigation can improve understanding of the…”
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Genome-wide meta-analysis identifies novel loci associated with age-related macular degeneration by Han, Xikun, Gharahkhani, Puya, Mitchell, Paul, Liew, Gerald, Hewitt, Alex W, MacGregor, Stuart

“…Age-related macular degeneration (AMD) is the leading cause of irreversible blindness among the elderly population. To accelerate the understanding of the…”
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The effects of eight serum lipid biomarkers on age-related macular degeneration risk: a Mendelian randomization study by Han, Xikun, Ong, Jue-Sheng, Hewitt, Alex W, Gharahkhani, Puya, MacGregor, Stuart

“…Abstract Background Age-related macular degeneration (AMD) is a leading cause of vision loss. Whereas lipids have been studied extensively to understand their…”
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Measurement of Systemic Mitochondrial Function in Advanced Primary Open-Angle Glaucoma and Leber Hereditary Optic Neuropathy by Van Bergen, Nicole J, Crowston, Jonathan G, Craig, Jamie E, Burdon, Kathryn P, Kearns, Lisa S, Sharma, Shiwani, Hewitt, Alex W, Mackey, David A, Trounce, Ian A

“…Primary Open Angle Glaucoma (POAG) is a common neurodegenerative disease characterized by the selective and gradual loss of retinal ganglion cells (RGCs)…”
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Prevalence of Keratoconus Based on Scheimpflug Imaging: The Raine Study by Chan, Elsie, Chong, Elaine W, Lingham, Gareth, Stevenson, Louis J, Sanfilippo, Paul G, Hewitt, Alex W, Mackey, David A, Yazar, Seyhan

“…To describe the prevalence and systemic associations of keratoconus in young adults in Perth, Western Australia. Cross-sectional study. One thousand two…”
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Projected worldwide disease burden from giant cell arteritis by 2050 by De Smit, Elisabeth, Palmer, Andrew J, Hewitt, Alex W

“…To estimate and project the number of people affected worldwide by giant cell arteritis (GCA) by 2050. Modeling the number of people visually impaired as a…”
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Gene therapy for visual loss: Opportunities and concerns by Lee, Jia Hui, Wang, Jiang-Hui, Chen, Jinying, Li, Fan, Edwards, Thomas L., Hewitt, Alex W., Liu, Guei-Sheung

“…Many clinical trials using gene therapy have shown significant therapeutic benefits and exceptional safety records. Increasing evidence is verifying the long…”
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A single‐cell transcriptome atlas of the adult human retina by Lukowski, Samuel W, Lo, Camden Y, Sharov, Alexei A, Nguyen, Quan, Fang, Lyujie, Hung, Sandy SC, Zhu, Ling, Zhang, Ting, Grünert, Ulrike, Nguyen, Tu, Senabouth, Anne, Jabbari, Jafar S, Welby, Emily, Sowden, Jane C, Waugh, Hayley S, Mackey, Adrienne, Pollock, Graeme, Lamb, Trevor D, Wang, Peng‐Yuan, Hewitt, Alex W, Gillies, Mark C, Powell, Joseph E, Wong, Raymond CB

“…The retina is a specialized neural tissue that senses light and initiates image processing. Although the functional organization of specific retina cells has…”
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TGC repeat expansion in the TCF4 gene increases the risk of Fuchs' endothelial corneal dystrophy in Australian cases by Kuot, Abraham, Hewitt, Alex W, Snibson, Grant R, Souzeau, Emmanuelle, Mills, Richard, Craig, Jamie E, Burdon, Kathryn P, Sharma, Shiwani

“…Fuchs' endothelial corneal dystrophy (FECD) is a progressive, vision impairing disease. Common single nucleotide polymorphisms (SNPs) and a trinucleotide…”
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Engineering domain-inlaid SaCas9 adenine base editors with reduced RNA off-targets and increased on-target DNA editing by Nguyen Tran, Minh Thuan, Mohd Khalid, Mohd Khairul Nizam, Wang, Qi, Walker, Jacqueline K. R., Lidgerwood, Grace E., Dilworth, Kimberley L., Lisowski, Leszek, Pébay, Alice, Hewitt, Alex W.

“…Precision genome engineering has dramatically advanced with the development of CRISPR/Cas base editing systems that include cytosine base editors and adenine…”
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Genome-Wide Meta-analysis Identifies Risk Loci and Improves Disease Prediction of Age-Related Macular Degeneration by He, Weixiong, Han, Xikun, Ong, Jue-Sheng, Wu, Yeda, Hewitt, Alex W, Mackey, David A, Gharahkhani, Puya, MacGregor, Stuart

“…To identify age-related macular degeneration (AMD) risk loci and to establish a polygenic prediction model. Genome-wide association study (GWAS) and polygenic…”
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Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma by MacGregor, Stuart, Ong, Jue-Sheng, An, Jiyuan, Han, Xikun, Zhou, Tiger, Siggs, Owen M., Law, Matthew H., Souzeau, Emmanuelle, Sharma, Shiwani, Lynn, David J., Beesley, Jonathan, Sheldrick, Bronwyn, Mills, Richard A., Landers, John, Ruddle, Jonathan B., Graham, Stuart L., Healey, Paul R., White, Andrew J. R., Casson, Robert J., Best, Stephen, Grigg, John R, Goldberg, Ivan, Powell, Joseph E., Whiteman, David C., Radford-Smith, Graham L., Martin, Nicholas G., Montgomery, Grant W., Burdon, Kathryn P., Mackey, David A., Gharahkhani, Puya, Craig, Jamie E., Hewitt, Alex W.

“…Intraocular pressure (IOP) is currently the sole modifiable risk factor for primary open-angle glaucoma (POAG), one of the leading causes of blindness…”
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Universal cell donor lines: A review of the current research by Simpson, Ariel, Hewitt, Alex W., Fairfax, Kirsten A.

“…Human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) hold promise for transplantation medicine. Diverse human leukocyte antigen (HLA)…”
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