Search Results - "Hewit, Kay"

Repurposing screen identifies mebendazole as a clinical candidate to synergise with docetaxel for prostate cancer treatment by Rushworth, Linda K., Hewit, Kay, Munnings-Tomes, Sophie, Somani, Sukrut, James, Daniel, Shanks, Emma, Dufès, Christine, Straube, Anne, Patel, Rachana, Leung, Hing Y.

“…Background Docetaxel chemotherapy in prostate cancer has a modest impact on survival. To date, efforts to develop combination therapies have not translated…”
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Atypical chemokine receptor ACKR2 controls branching morphogenesis in the developing mammary gland by Wilson, Gillian J, Hewit, Kay D, Pallas, Kenneth J, Cairney, Claire J, Lee, Kit M, Hansell, Christopher A, Stein, Torsten, Graham, Gerard J

“…Macrophages are important regulators of branching morphogenesis during development and postnatally in the mammary gland. Regulation of macrophage dynamics…”
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The N-terminal Region of the Atypical Chemokine Receptor ACKR2 Is a Key Determinant of Ligand Binding by Hewit, Kay D., Fraser, Alasdair, Nibbs, Robert J.B., Graham, Gerard J.

“…The atypical chemokine receptor, ACKR2 is a pivotal regulator of chemokine-driven inflammatory responses and works by binding, internalizing, and degrading…”
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Pancreas-derived mesenchymal stromal cells share immune response-modulating and angiogenic potential with bone marrow mesenchymal stromal cells and can be grown to therapeutic scale under Good Manufacturing Practice conditions by Thirlwell, Kayleigh L., Colligan, David, Mountford, Joanne C., Samuel, Kay, Bailey, Laura, Cuesta-Gomez, Nerea, Hewit, Kay D., Kelly, Christopher J, West, Christopher C., McGowan, Neil W.A., Casey, John J., Graham, Gerard J., Turner, Marc L., Forbes, Shareen, Campbell, John D.M.

“…Mesenchymal stromal cells (MSCs) isolated from various tissues are under investigation as cellular therapeutics in a wide range of diseases. It is appreciated…”
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Targeting BCR-ABL-Independent TKI Resistance in Chronic Myeloid Leukemia by mTOR and Autophagy Inhibition by Mitchell, Rebecca, Hopcroft, Lisa E M, Baquero, Pablo, Allan, Elaine K, Hewit, Kay, James, Daniel, Hamilton, Graham, Mukhopadhyay, Arunima, O’Prey, Jim, Hair, Alan, Melo, Junia V, Chan, Edmond, Ryan, Kevin M, Maguer-Satta, Véronique, Druker, Brian J, Clark, Richard E, Mitra, Subir, Herzyk, Pawel, Nicolini, Franck E, Salomoni, Paolo, Shanks, Emma, Calabretta, Bruno, Holyoake, Tessa L, Helgason, G Vignir

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Chemokines as novel and versatile reagents for flow cytometry and cell sorting by Le Brocq, Michelle L, Fraser, Alasdair R, Cotton, Graham, Woznica, Kerry, McCulloch, Clare V, Hewitt, Kay D, McKimmie, Clive S, Nibbs, Robert J B, Campbell, John D M, Graham, Gerard J

“…Cell therapy regimens are frequently compromised by low-efficiency cell homing to therapeutic niches. Improvements in this regard would enhance effectiveness…”
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Targeting BCR-ABL-Independent TKI Resistance in Chronic Myeloid Leukemia by mTOR and Autophagy Inhibition by Mitchell, Rebecca, Hopcroft, Lisa E M, Baquero, Pablo, Allan, Elaine K, Hewit, Kay, James, Daniel, Hamilton, Graham, Mukhopadhyay, Arunima, O'Prey, Jim, Hair, Alan, Melo, Junia V, Chan, Edmond, Ryan, Kevin M, Maguer-Satta, Véronique, Druker, Brian J, Clark, Richard E, Mitra, Subir, Herzyk, Pawel, Nicolini, Franck E, Salomoni, Paolo, Shanks, Emma, Calabretta, Bruno, Holyoake, Tessa L, Helgason, G Vignir

“…Imatinib and second-generation tyrosine kinase inhibitors (TKIs) nilotinib and dasatinib have statistically significantly improved the life expectancy of…”
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An analysis of the function and expression of D6 on lymphatic endothelial cells by McKimmie, Clive S., Singh, Mark D., Hewit, Kay, Lopez-Franco, Oscar, Le Brocq, Michelle, Rose-John, Stefan, Lee, Kit Ming, Baker, Andrew H., Wheat, Rachel, Blackbourn, David J., Nibbs, Robert J.B., Graham, Gerard J.

“…The mechanisms by which CC chemokine receptor (CCR)7 ligands are selectively presented on lymphatic endothelium in the presence of inflammatory chemokines are…”
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A functional genomics screen reveals a strong synergistic effect between docetaxel and the mitotic gene DLGAP5 that is mediated by the androgen receptor by Hewit, Kay, Sandilands, Emma, Martinez, Rafael Sanchez, James, Daniel, Leung, Hing Y., Bryant, David M., Shanks, Emma, Markert, Elke K.

“…Based on a molecular classification of prostate cancer using gene expression pathway signatures, we derived a set of 48 genes in critical pathways that…”
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Identification of a Clinically Relevant Signature for Early Progression in KRAS-Driven Lung Adenocarcinoma by Neidler, Sarah, Kruspig, Björn, Hewit, Kay, Monteverde, Tiziana, Gyuraszova, Katarina, Braun, Attila, Clark, William, James, Daniel, Hedley, Ann, Nieswandt, Bernhard, Shanks, Emma, Dick, Craig, Murphy, Daniel J

“…Inducible genetically defined mouse models of cancer uniquely facilitate the investigation of early events in cancer progression, however, there are valid…”
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Biochemical features important for d6 function by Hewit, Kay Deborah

“…Chemokines are the principle regulators of leukocyte migration in vivo and function during both normal (homeostatic) and inflammatory conditions to direct…”
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